Anti-ZFP36 Antibody (R3H15)

Catalog No.

RHD71701

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a

Clonality

Monoclonal

Tested applications

IHC: 1:100-1:200

Target

Zinc finger protein 36, RNF162A, TIS11A, Growth factor-inducible nuclear protein NUP475, Zfp-36, ZFP36, G0/G1 switch regulatory protein 24, G0S24, Tristetraprolin, NUP475, mRNA decay activator protein ZFP36, TTP

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P26651

Applications

IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3H15

ZFP36-family RNA-binding proteins in regulatory T cells reinforce immune homeostasis., PMID:40328742

Senescence-induced p21high macrophages contributed to CD8+ T cells-related immune hyporesponsiveness in kidney transplantation via Zfp36/IL-27 axis., PMID:40234384

Copy number variation and clinical response to chemotherapy and bevacizumab in the Czech metastatic colorectal cancer patients., PMID:39174331

The RNA binding proteins ZFP36L1 and ZFP36L2 are dysregulated in airway epithelium in human and a murine model of asthma., PMID:37928904

Tristetraprolin overexpression drives hematopoietic changes in young and middle-aged mice generating dominant mitigating effects on induced inflammation in murine models., PMID:37535204

RNA Sequencing Reveals Beneficial Effects of Atorvastatin on Endothelial Cells in Acute Kawasaki Disease., PMID:35861833

Cisplatin resistance of NSCLC cells involves upregulation of visfatin through activation of its transcription and stabilization of mRNA., PMID:34656559

Regulated Tristetraprolin Overexpression Dampens the Development and Pathogenesis of Experimental Autoimmune Uveitis., PMID:33569048

Tristetraprolin Regulates TH17 Cell Function and Ameliorates DSS-Induced Colitis in Mice., PMID:32922402

Dynamics of peripheral T cell clones during PD-1 blockade in non-small cell lung cancer., PMID:32591861

Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1., PMID:28394372

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence., PMID:27102483

Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies., PMID:26831084

Sustained interleukin-1β exposure modulates multiple steps in glucocorticoid receptor signaling, promoting split-resistance to the transactivation of prominent anti-inflammatory genes by glucocorticoids., PMID:25977599

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes., PMID:22701344

A synonymous polymorphism of the Tristetraprolin (TTP) gene, an AU-rich mRNA-binding protein, affects translation efficiency and response to Herceptin treatment in breast cancer patients., PMID:21875902

Constitutive ERK activity induces downregulation of tristetraprolin, a major protein controlling interleukin8/CXCL8 mRNA stability in melanoma cells., PMID:21593445

Involvement of Tis11b, an AU-rich binding protein, in induction of apoptosis by rituximab in B cell chronic lymphocytic leukemia cells., PMID:19092855

Production and characterization of ZFP36L1 antiserum against recombinant protein from Escherichia coli., PMID:18302406

Inhibition of TGF-beta signaling by IL-15: a new role for IL-15 in the loss of immune homeostasis in celiac disease., PMID:17324400

Expression, purification, and biochemical characterization of the antiinflammatory tristetraprolin: a zinc-dependent mRNA binding protein affected by posttranslational modifications., PMID:15504035

[Analysis of the kinetic of expression of tristetraprolin and HuR by rheumatoid arthritis patients peripheral blood mononuclear cells stimulated with lipopolysaccharide]., PMID:15309217

Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs., PMID:15280467

Expression of tristetraprolin (G0S24) mRNA, a regulator of tumor necrosis factor-alpha production, in synovial tissues of patients with rheumatoid arthritis., PMID:15170914

Regulation and localization of endogenous human tristetraprolin., PMID:12823857

Analysis of the function, expression, and subcellular distribution of human tristetraprolin., PMID:12115244

Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling., PMID:11796723

HuA and tristetraprolin are induced following T cell activation and display distinct but overlapping RNA binding specificities., PMID:11602610

Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome., PMID:11588035

Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFalpha overproduction., PMID:9276715

A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency., PMID:8630730

Schizosaccharomyces pombe zfs1+ encoding a zinc-finger protein functions in the mating pheromone recognition pathway., PMID:8534915

Protein kinase C isozyme distribution and down-regulation in relation to insulin-stimulated c-fos induction., PMID:8063739

Document Download

Anti-ZFP36 Antibody (R3H15).pdf