Anti-DNMT1 Antibody (R3H03)

Catalog No.

RHD69903

Species reactivity

Human, Monkey

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, IHC: 1:200-1:1000, WB: 1:500-1:2000

Target

CXXC-type zinc finger protein 9, MCMT, AIM, DNMT1, DNA MTase HsaI, DNMT, DNA (cytosine-5)-methyltransferase 1, Dnmt1, DNA methyltransferase HsaI, M.HsaI, CXXC9

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P26358

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3H03

Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population., PMID:40024396

Potentiating anti-tumor immunity by re-engaging immune synapse molecules., PMID:39999838

Dulaglutide reduces oxidative DNA damage and hypermethylation in the somatic cells of mice fed a high-energy diet by restoring redox balance, inflammatory responses, and DNA repair gene expressions., PMID:38963172

Flow cytometry of DNMT1 as a biomarker of hypomethylating therapies., PMID:38345160

Prothymosin α accelerates dengue virus-induced thrombocytopenia., PMID:38213625

Amino acids analysis reveals serum methionine contributes to diagnosis of the Kawasaki disease in mice and children., PMID:38008045

Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells., PMID:37709749

PD-L1 Downregulation and DNA Methylation Inhibition for Molecular Therapy against Cancer Stem Cells in Hepatocellular Carcinoma., PMID:37686163

A Porcine DNMT1 Variant: Molecular Cloning and Generation of Specific Polyclonal Antibody., PMID:37510229

Mesenchymal stem cells, as glioma exosomal immunosuppressive signal multipliers, enhance MDSCs immunosuppressive activity through the miR-21/SP1/DNMT1 positive feedback loop., PMID:37481646

Epigenetically modified AP-2α by DNA methyltransferase facilitates glioma immune evasion by upregulating PD-L1 expression., PMID:37330579

Diagnostic Utility of TSSC3 and RB1 Immunohistochemistry in Hydatidiform Mole., PMID:37298606

Potential Pathogenic Impact of Cow's Milk Consumption and Bovine Milk-Derived Exosomal MicroRNAs in Diffuse Large B-Cell Lymphoma., PMID:37047075

Rngtt governs biliary-derived liver regeneration initiation by transcriptional regulation of mTORC1 and Dnmt1 in zebrafish., PMID:36724876

Crosstalk between macrophage-derived PGE2 and tumor UHRF1 drives hepatocellular carcinoma progression., PMID:35664070

[Mechanism of Mycobacterium tuberculosis on interleukin-6 receptor 3'-untranslated region methylation in CD4+T cells]., PMID:35381636

Global DNA methylation and increased DNMT3A expression in multiple myeloma patients., PMID:35173353

Decitabine potentiates efficacy of doxorubicin in a preclinical trastuzumab-resistant HER2-positive breast cancer models., PMID:35091237

Epigenetic comparison of CHO hosts and clones reveals divergent methylation and transcription patterns across lineages., PMID:35028935

IRAK1-regulated IFN-γ signaling induces MDSC to facilitate immune evasion in FGFR1-driven hematological malignancies., PMID:34906138

Disulfiram Improves the Anti-PD-1 Therapy Efficacy by Regulating PD-L1 Expression via Epigenetically Reactivation of IRF7 in Triple Negative Breast Cancer., PMID:34858816

Z-DNA as a Tool for Nuclease-Free DNA Methyltransferase Assay., PMID:34769422

Common mechanisms cannot explain time- and dose-dependent DNA methylation changes in earthworms exposed to cadmium., PMID:34742794

Embryo culture media differentially alter DNA methylating enzymes and global DNA methylation in embryos and oocytes., PMID:34741214

Global histone modification analysis reveals hypoacetylated H3 and H4 histones in B Cells from systemic lupus erythematosus patients., PMID:34614442

Acetylated DNMT1 Downregulation and Related Regulatory Factors Influence Metastatic Melanoma Patients Survival., PMID:34572918

Supplementation of oleic acid, stearic acid, palmitic acid and β-hydroxybutyrate increase H3K9me3 in endometrial epithelial cells of cattle cultured in vitro., PMID:34560342

MALAT1 Promotes Tumorigenesis and Increases Cellular Sensitivity to Herceptin in HER2-positive Breast Cancer., PMID:34148540

Detection of the level of DNMT1 based on self-assembled probe signal amplification technique in plasma., PMID:34119770

Integrated Transcriptomic and Epigenetic Study of PCOS: Impact of Map3k1 and Map1lc3a Promoter Methylation on Autophagy., PMID:33763111

Regulation of Toll-like receptor-mediated inflammatory response by microRNA-152-3p-mediated demethylation of MyD88 in systemic lupus erythematosus., PMID:33507312

Nanobody-mediated control of gene expression and epigenetic memory., PMID:33483487

Peripheral blood mononuclear cells are hypomethylated in active rheumatoid arthritis and methylation correlates with disease activity., PMID:33200208

Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction., PMID:32807789

Melatonin-induced suppression of DNA methylation promotes odontogenic differentiation in human dental pulp cells., PMID:32718272

Obesity promotes the global hypomethylation of CD4+ T cells in patients with systemic lupus erythematosus via downregulating DNMT1., PMID:32573524

Immunity and autoantibodies of a mouse strain with autistic-like behavior., PMID:34589851

B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response., PMID:32270032

Alterations in peripheral blood B cells in systemic lupus erythematosus patients with renal insufficiency., PMID:32248020

Induction of Rabies Virus Infection in Mice Brain may Up and Down Regulate Type II Interferon gamma via epigenetic modifications., PMID:32172520

Enhanced expression of miR-21 and miR-150 is a feature of anti-mitochondrial antibody-negative primary biliary cholangitis., PMID:31948396

Association analysis of DNA methyltransferases in IgA nephropathy., PMID:31931367

Epigenetics and prostate cancer: defining the timing of DNA methyltransferase deregulation during prostate cancer progression., PMID:31864524

DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma., PMID:31595037

Regulation of DNA methylation levels in the process of oral mucosal regeneration in a rat oral ulcer model., PMID:31286466

Decreased DNA methyltransferases expression is associated with coronary artery lesion formation in Kawasaki disease., PMID:31171909

ROR1-targeted delivery of miR-29b induces cell cycle arrest and therapeutic benefit in vivo in a CLL mouse model., PMID:31151986

Enhanced chemiluminescence enzyme-linked immunoassay for the determination of DNA methyltransferase 1 in human serum., PMID:30887691

Aflatoxin B1 Induces Immunotoxicity through the DNA Methyltransferase-Mediated JAK2/STAT3 Pathway in 3D4/21 Cells., PMID:30848898

Blockade of TNFα to Improve Human CD34+ Cell Repopulating Activity in Allogeneic Stem Cell Transplantation., PMID:30723481

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