Catalog No.
RHD69006
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000
Target
NFKBI, Major histocompatibility complex enhancer-binding protein MAD3, IkB-alpha, IkappaBalpha, I-kappa-B-alpha, IKBA, NF-kappa-B inhibitor alpha, NFKBIA, MAD3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P25963
Applications
ELISA, FCM, IF
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3G94
Formononetin inhibits IgE by huPlasma/PBMCs and mast cells/basophil activation via JAK/STAT/PI3-Akt pathways., PMID:39221239
Extracellular NCOA4 is a mediator of septic death by activating the AGER-NFKB pathway., PMID:38916095
A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation., PMID:36685499
Single cell sequencing revealed the mechanism of PD-1 resistance affected by the expression profile of peripheral blood immune cells in ESCC., PMID:36466860
Characterization of immune checkpoint inhibitor-induced cardiotoxicity reveals interleukin-17A as a driver of cardiac dysfunction after anti-PD-1 treatment., PMID:36356191
IKBKE and BANK1 Polymorphisms and Clinical Characteristics in Chinese Women with Systemic Lupus Erythematosus., PMID:35930382
Dual BTK/SYK inhibition with CG-806 (luxeptinib) disrupts B-cell receptor and Bcl-2 signaling networks in mantle cell lymphoma., PMID:35296646
Single-Cell Transcriptome Analysis of Chronic Antibody-Mediated Rejection After Renal Transplantation., PMID:35111153
Mismatch repair-deficient prostate cancer with parenchymal brain metastases treated with immune checkpoint blockade., PMID:34140335
T and B Lymphocyte Transcriptional States Differentiate between Sensitized and Unsensitized Individuals in Alpha-Gal Syndrome., PMID:33804792
A system-view of Bordetella pertussis booster vaccine responses in adults primed with whole-cell versus acellular vaccine in infancy., PMID:33690224
Refractory systemic juvenile idiopathic arthritis successfully treated with rapamycin., PMID:33547778
Modulatory effect of Tagetes erecta flowers essential oils via Nrf2/HO-1/NF-κB/p65 axis mediated suppression of N-methyl-N'nitro-N-nitroguanidine (MNNG) induced gastric cancer in rats., PMID:33394271
IκBα Nuclear Export Enables 4-1BB-Induced cRel Activation and IL-2 Production to Promote CD8 T Cell Immunity., PMID:32817348
Anti-Interleukin-10 Unleashes Transcriptional Response to Leishmanial Antigens in Visceral Leishmaniasis Patients., PMID:32614452
Clinical Management and Therapeutic Strategies for the Thyroid-Associated Ophthalmopathy: Current and Future Perspectives., PMID:32567373
TAK1 signaling activity links the mast cell cytokine response and degranulation in allergic inflammation., PMID:32108376
A novel NFKBIA variant substituting serine 36 of IκBα causes immunodeficiency with warts, bronchiectasis and juvenile rheumatoid arthritis in the absence of ectodermal dysplasia., PMID:31683054
Simulation of the Dynamics of Primary Immunodeficiencies in B Cells., PMID:30116248
(R)-(+)-pulegone suppresses allergic and inflammation responses on 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice model., PMID:29933898
Astragalus polysaccharides exerts anti-infective activity by inducing human cathelicidin antimicrobial peptide LL-37 in respiratory epithelial cells., PMID:29672953
Transcriptome of Porcine PBMCs over Two Generations Reveals Key Genes and Pathways Associated with Variable Antibody Responses post PRRSV Vaccination., PMID:29410429
Polymorphisms associated with adalimumab and infliximab response in moderate-to-severe plaque psoriasis., PMID:29192552
DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression., PMID:28560426
Functional importance of stripping in NFκB signaling revealed by a stripping-impaired IκBα mutant., PMID:28167786
Pharmacogenetics of ustekinumab in patients with moderate-to-severe plaque psoriasis., PMID:27977334
CAPE suppresses migration and invasion of prostate cancer cells via activation of non-canonical Wnt signaling., PMID:27191743
HLA-Cw6 allele, NFkB1 and NFkBIA polymorphisms play no role in predicting response to etanercept in psoriatic patients., PMID:27348478
A Prospective Pharmacogenomic Study of Crohn's Disease Patients during Routine Therapy with Anti-TNF-α Drug Adalimumab: Contribution of ATG5, NFKB1, and CRP Genes to Pharmacodynamic Variability., PMID:27096233
Identification of genes responsible for RelA-dependent proliferation arrest in human mammary epithelial cells conditionally expressing RelA., PMID:26981373
Blood Transcriptome Profiling in Myasthenia Gravis Patients to Assess Disease Activity: A Pilot RNA-seq Study., PMID:26924932
Anti-inflammatory effect of curcumin on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse., PMID:26507910
Attenuation of the macrophage inflammatory activity by TiO₂ nanotubes via inhibition of MAPK and NF-κB pathways., PMID:26491301
The AhR and NF-κB/Rel Proteins Mediate the Inhibitory Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on the 3' Immunoglobulin Heavy Chain Regulatory Region., PMID:26377645
Intrinsic Differences in Donor CD4 T Cell IL-2 Production Influence Severity of Parent-into-F1 Murine Lupus by Skewing the Immune Response Either toward Help for B Cells and a Sustained Autoantibody Response or toward Help for CD8 T Cells and a Downregulatory Th1 Response., PMID:26320249
Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF-κB in colon cancer., PMID:26318844
CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts., PMID:26195726
Immunostimulatory polysaccharide isolated from the leaves of Diospyros kaki Thumb modulate macrophage via TLR2., PMID:26093315
Celastrol inhibits inflammatory stimuli-induced neutrophil extracellular trap formation., PMID:25941817
TAT cell-penetrating peptide modulates inflammatory response and apoptosis in human lung epithelial cells., PMID:25916485
NF-κB regulates caspase-4 expression and sensitizes neuroblastoma cells to Fas-induced apoptosis., PMID:25695505
Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in IκBα., PMID:25601653
The mAb against adipocyte fatty acid-binding protein 2E4 attenuates the inflammation in the mouse model of high-fat diet-induced obesity via toll-like receptor 4 pathway., PMID:25596549
Enterovirus-71 virus-like particles induce the activation and maturation of human monocyte-derived dendritic cells through TLR4 signaling., PMID:25360749
Andrographolide attenuates interleukin-1β-stimulated upregulation of chemokine CCL5 and glial fibrillary acidic protein in astrocytes., PMID:24949817
NF-κB-mediated integrin-linked kinase regulation in angiotensin II-induced pro-fibrotic process in cardiac fibroblasts., PMID:24802124
Assaying NF-κB activation and signaling from TNF receptors., PMID:24788168
Nuclear factor κB-dependent regulation of angiogenesis, and metastasis in an in vivo model of thyroid cancer is associated with secreted interleukin-8., PMID:24758177
PMC, a potent hydrophilic α-tocopherol derivative, inhibits NF-κB activation via PP2A but not IκBα-dependent signals in vascular smooth muscle cells., PMID:24725826
Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate., PMID:24586752
For research use only. Not for human or drug use.
