Catalog No.
RHD53604
Species reactivity
Human, Mouse, Rat, Rabbit, Monkey
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:50-1:500, IHC: 1:100-1:500, WB: 1:500-1:2000
Target
CBL, RING finger protein 55, Proto-oncogene c-Cbl, CBL2, E3 ubiquitin-protein ligase CBL, RING-type E3 ubiquitin transferase CBL, Casitas B-lineage lymphoma proto-oncogene, Signal transduction protein CBL, RNF55
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P22681
Applications
ELISA, FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3G21
Unlocking LAG3: Ubiquitin's unexpected role., PMID:40315815
Long-term safety, tolerability, and efficacy of eptinezumab in chronic cluster headache (CHRONICLE): an open-label safety trial., PMID:40252664
Ras-MAPK pathway in patients with lupus nephritis., PMID:40102014
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs., PMID:40101708
DDO-adjuvanted influenza A virus nucleoprotein mRNA vaccine induces robust humoral and cellular type 1 immune responses and protects mice from challenge., PMID:39692514
CBL-B - An upcoming immune-oncology target., PMID:39582379
DDO-adjuvanted influenza A virus nucleoprotein mRNA vaccine induces robust humoral and cellular type 1 immune responses and protects mice from challenge., PMID:39553933
T-cell exhaustion-related genes in Graves' disease: a comprehensive genome mapping analysis., PMID:39239096
Development and characterization of dendritic cell internalization and activation assays contributing to the immunogenicity risk evaluation of biotherapeutics., PMID:39229274
Casitas b cell lymphoma‑B (Cbl-b): A new therapeutic avenue for small-molecule immunotherapy., PMID:38457911
Development of IFNβ-1a versions with reduced immunogenicity and full in vitro biological activity for the treatment of multiple sclerosis., PMID:37931868
A new multi-epitope vaccine candidate based on S and M proteins is effective in inducing humoral and cellular immune responses against SARS-CoV-2 variants: an in silico design approach., PMID:37874075
Design and characterization of chimeric Rabies-SARS-CoV-2 virus-like particles for vaccine purposes., PMID:37126083
Specific sequence mutations in a long-lasting rhIFN-α2b version reduce in vitro and in vivo immunogenicity and increase in vitro protein stability., PMID:37020947
Cbl-b inhibited CD4+ T cell activation by regulating the expression of miR-99a/miR-125b., PMID:36634415
Generation and functional evaluation of novel monoclonal antibodies targeting glycosylated human stem cell factor., PMID:36401641
Design and optimization of an IgG human ELISA assay reactive to recombinant RBD SARS-CoV-2 protein., PMID:36329132
Immune dysregulation caused by homozygous mutations in CBLB., PMID:36006710
Rapid and efficient generation of antigen-specific isogenic T cells from cryopreserved blood samples., PMID:35194830
Rational design of novel fusion rabies glycoproteins displaying a major antigenic site of foot-and-mouth disease virus for vaccine applications., PMID:34971413
Development, Production, and Characterization of Hepatitis B Subviral Envelope Particles as a Third-Generation Vaccine., PMID:34914052
Development of highly stable and de-immunized versions of recombinant alpha interferon: Promising candidates for the treatment of chronic and emerging viral diseases., PMID:34798238
Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling., PMID:34526379
Detection and quantification of anti-rabies glycoprotein antibodies: current state and perspectives., PMID:34448897
Pathogenic Germline Variants in Cancer Susceptibility Genes in Children and Young Adults With Rhabdomyosarcoma., PMID:34095712
Cbl-b deficiency prevents functional but not phenotypic T cell anergy., PMID:33974042
Chimeric VLPs Based on HIV-1 Gag and a Fusion Rabies Glycoprotein Induce Specific Antibodies against Rabies and Foot-and-Mouth Disease Virus., PMID:33809060
Bifunctional GM-CSF-derived peptides as tools for O-glycoengineering and protein tagging., PMID:33387593
Nitric Oxide Inhibits NF-κB-mediated Survival Signaling: Possible Role in Overcoming TRAIL Resistance., PMID:33288568
CBL0137 increases the targeting efficacy of Rovalpituzumab tesirine against tumour-initiating cells in small cell lung cancer., PMID:33257843
Development of a panel of serum IgG and IgA autoantibodies for early diagnosis of colon cancer., PMID:33162802
Characterization of hepatitis B virus surface antigen particles expressed in stably transformed mammalian cell lines containing the large, middle and small surface protein., PMID:32979402
Rabies VLPs adjuvanted with saponin-based liposomes induce enhanced immunogenicity mediated by neutralizing antibodies in cattle, dogs and cats., PMID:32905818
Cbls boost B cells., PMID:32813871
Targeted next-generation sequencing reveals molecular heterogeneity in non-chronic lymphocytic leukemia clonal B-cell lymphocytosis., PMID:32738175
Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing., PMID:32584413
The effect of Casitas b-lineage lymphoma b on regulating T follicular helper in lupus nephritis., PMID:32373983
The glycosylation of anti-rhIFN-α2b recombinant antibodies influences the antigen-neutralizing activity., PMID:32285235
β-Elemene inhibits the metastasis of multidrug-resistant gastric cancer cells through miR-1323/Cbl-b/EGFR pathway., PMID:32199253
Optimization and validation of a blocking ELISA for quantitation of anti-rabies immunoglobulins in multispecies sera., PMID:32170383
Cobalamin c deficiency associated with antifactor h antibody-associated hemolytic uremic syndrome in a young adult., PMID:32164588
Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness., PMID:32051419
Ubiquitination of IgG1 cytoplasmic tail modulates B-cell signalling and activation., PMID:32006024
Cytoskeletal Protein 4.1R Is a Positive Regulator of the FcεRI Signaling and Chemotaxis in Mast Cells., PMID:31993060
c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth., PMID:31882749
Syk degradation restrains plasma cell formation and promotes zonal transitions in germinal centers., PMID:31873727
Construction, expression and functional analysis of anti-clenbuterol codon-optimized scFv recombinant antibody., PMID:31738983
An Antibody Specific for the Dog Leukocyte Antigen DR (DLA-DR) and Its Novel Methotrexate Conjugate Inhibit the Growth of Canine B Cell Lymphoma., PMID:31561563
Molecular Mechanisms and Countermeasures of Immunotherapy Resistance in Malignant Tumor., PMID:31205532
SLAP Is a Negative Regulator of FcεRI Receptor-Mediated Signaling and Allergic Response., PMID:31156621
For research use only. Not for human or drug use.
