Catalog No.
RHD27705
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
PTPN1, PTP-1B, Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B, PTP1B
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P18031
Applications
ELISA, FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3E94
Dual Conjugation of Long- and Medium-Chain Fatty Acids to BimBH3 Peptide Yields Ultra Long-Acting Inhibitors of Intracellular PTPN1/2., PMID:40458949
Autoinflammatory encephalopathy due to PTPN1 haploinsufficiency: a case series., PMID:39986310
Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation., PMID:38563147
PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin., PMID:38199575
Small molecule. Big biology. Dual phosphatase inhibitor enters the immunotherapy fray., PMID:37982351
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity., PMID:37794185
Integrated analysis identifies the IL6/JAK/STAT signaling pathway and the estrogen response pathway associated with the pathogenesis of intracranial aneurysms., PMID:36451838
Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling., PMID:34526379
PD-L1 tumor-intrinsic signaling and its therapeutic implication in triple-negative breast cancer., PMID:33884962
Protein tyrosine phosphatase 1B as a therapeutic target for Graves' orbitopathy in an in vitro model., PMID:32760098
Protein tyrosine phosphatase PTPN1 modulates cell growth and associates with poor outcome in human neuroblastoma., PMID:31837707
Inhibition of PTP1B Promotes M2 Polarization via MicroRNA-26a/MKP1 Signaling Pathway in Murine Macrophages., PMID:31474996
A connection between reversible tyrosine phosphorylation and SNARE complex disassembly activity of N-ethylmaleimide-sensitive factor unveiled by the phosphomimetic mutant N-ethylmaleimide-sensitive factor-Y83E., PMID:31194868
Infliximab ameliorates tumor necrosis factor-alpha-induced insulin resistance by attenuating PTP1B activation in 3T3L1 adipocytes in vitro., PMID:30260514
The HSV-1 mechanisms of cell-to-cell spread and fusion are critically dependent on host PTP1B., PMID:29742155
Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development., PMID:29348454
S-nitrosylation of endogenous protein tyrosine phosphatases in endothelial insulin signaling., PMID:27521458
Protein tyrosine phosphatase 1B (PTP1B) is dispensable for IgE-mediated cutaneous reaction in vivo., PMID:27311921
Protein tyrosine phosphatase 1B negatively regulates S100A9-mediated lung damage during respiratory syncytial virus exacerbations., PMID:26813343
Anti-diabetic effects of Ganoderma lucidum., PMID:25790910
Protein tyrosine phosphatase 1B inhibition protects against podocyte injury and proteinuria., PMID:24951831
Leptin and leptin-related gene polymorphisms, obesity, and influenza A/H1N1 vaccine-induced immune responses in older individuals., PMID:24360890
A conserved rod domain phosphotyrosine that is targeted by the phosphatase PTP1B promotes keratin 8 protein insolubility and filament organization., PMID:24003221
Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells., PMID:23867504
CB₁ cannabinoid receptors promote maximal FAK catalytic activity by stimulating cooperative signaling between receptor tyrosine kinases and integrins in neuronal cells., PMID:23571270
Dominant role of the protein-tyrosine phosphatase CD148 in regulating platelet activation relative to protein-tyrosine phosphatase-1B., PMID:23065825
A monoclonal antibody against the catalytic domain of PTP1B., PMID:22741586
ER-bound protein tyrosine phosphatase PTP1B interacts with Src at the plasma membrane/substrate interface., PMID:22701734
Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice., PMID:21708244
PTPIP51 is phosphorylated by Lyn and c-Src kinases lacking dephosphorylation by PTP1B in acute myeloid leukemia., PMID:21513978
PTPIP51-a myeloid lineage specific protein interacts with PTP1B in neutrophil granulocytes., PMID:20627780
The role of protein tyrosine phosphatases in the regulation of allergic asthma: implication of TC-PTP and PTP-1B in the modulation of disease development., PMID:19930043
Identification of protein tyrosine phosphatases and dual-specificity phosphatases in mammalian spermatozoa and their role in sperm motility and protein tyrosine phosphorylation., PMID:19211810
PTP1B dephosphorylates N-ethylmaleimide-sensitive factor and elicits SNARE complex disassembly during human sperm exocytosis., PMID:19208619
Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity., PMID:19029027
Endoplasmic reticulum stress induces leptin resistance., PMID:18755873
A brake becomes an accelerator: PTP1B--a new therapeutic target for breast cancer., PMID:17349579
Interaction between the insulin receptor and Grb14: a dynamic study in living cells using BRET., PMID:16934761
Stimulation of the alveolar macrophage respiratory burst by ADP causes selective glutathionylation of protein tyrosine phosphatase 1B., PMID:16781456
ER-bound PTP1B is targeted to newly forming cell-matrix adhesions., PMID:16522684
Severely impaired insulin signaling in chronic wounds of diabetic ob/ob mice: a potential role of tumor necrosis factor-alpha., PMID:16507892
A glutathione S-transferase pi-activated prodrug causes kinase activation concurrent with S-glutathionylation of proteins., PMID:16288082
Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure., PMID:16234234
Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression., PMID:16179349
Monitoring the activation state of the insulin-like growth factor-1 receptor and its interaction with protein tyrosine phosphatase 1B using bioluminescence resonance energy transfer., PMID:15976035
Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice., PMID:15699041
Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP., PMID:15632081
Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action., PMID:15031294
Entamoeba histolytica-induced dephosphorylation in host cells., PMID:11895943
Identification of an IGF-1R kinase regulatory phosphatase using the fission yeast Schizosaccharomyces pombe and a GFP tagged IGF-1R in mammalian cells., PMID:11836447
For research use only. Not for human or drug use.
