Anti-TPH1 Antibody (R3E78)

Catalog No.

RHD26202

Species reactivity

Human

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

IHC: 1:50

Target

Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1, TRPH, TPH1, TPRH, TPH

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P17752

Applications

IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3E78

Mast cells help organize the Peyer's patch niche for induction of IgA responses., PMID:38427721

The response of CD27+CD38+ plasmablasts, CD24hiCD38hi transitional B cells, CXCR5-ICOS+PD-1+ Tph, Tph2 and Tfh2 subtypes to allergens in children with allergic asthma., PMID:38424520

CD11chigh B Cell Expansion Is Associated With Severity and Brain Atrophy in Neuromyelitis Optica., PMID:38350043

Serological Investigation of Persistent Villous Atrophy in Celiac Disease., PMID:37753949

Rituximab induces a transient fluctuation of peripheral and follicular helper T cells in neuromyelitis optica spectrum disorder., PMID:37536049

Hypertrophic cardiomyopathy induces changes in the tryptophan-5-hydroxylase, serotonin transporter and serotonergic receptors expressions., PMID:36657118

Triptófano-5-hidroxilasa, transportador de serotonina y receptores serotoninérgicos en miocardiopatía dilatada., PMID:36472833

TPH1 and 5-HT7 Receptor Overexpression Leading to Gemcitabine-Resistance Requires Non-Canonical Permissive Action of EZH2 in Pancreatic Ductal Adenocarcinoma., PMID:34771469

Administration of cyclophosphamide to rats induces pica and potentiates 5-hydroxytryptamine synthesis in the intestine without causing severe intestinal injury., PMID:34507634

IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor., PMID:33432230

IFN-γ inhibits 5-HT-induced melanin biosynthesis via downregulation of 5-HT receptors in vivo/in vitro., PMID:31519333

PD-1+CXCR5-CD4+T cells are correlated with the severity of systemic lupus erythematosus., PMID:31180450

[Metabolic analysis of serotonin system in serum and gastric tissues of ovalbumin-induced allergic mice]., PMID:29973322

Serotonin Exhibits Accelerated Bleomycin-Induced Pulmonary Fibrosis through TPH1 Knockout Mouse Experiments., PMID:29849496

Increase in chromogranin A- and serotonin-positive cells in pouch mucosa of patients with ulcerative colitis undergoing proctocolectomy., PMID:29803758

Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites., PMID:29576437

Intraspinal serotonergic neurons consist of two, temporally distinct populations in developing zebrafish., PMID:26437856

[Difference in target antigens between central tolerance and peripheral tolerance deficiencies]., PMID:26213192

Gastrointestinal immunity against tryptophan hydroxylase-1, aromatic L-amino-acid decarboxylase, AIE-75, villin and Paneth cells in APECED., PMID:25805658

Disease specificity of anti-tryptophan hydroxylase-1 and anti-AIE-75 autoantibodies in APECED and IPEX syndrome., PMID:25463430

Systemic protection through remote ischemic preconditioning is spread by platelet-dependent signaling in mice., PMID:24700614

Enteroendocrine cells are specifically marked by cell surface expression of claudin-4 in mouse small intestine., PMID:24603700

Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism., PMID:24558199

Overexpression of gastric leptin precedes adipocyte leptin during high-fat diet and is linked to 5HT-containing enterochromaffin cells., PMID:24468700

Autoantibodies against aromatic amino acid hydroxylases in patients with autoimmune polyendocrine syndrome type 1 target multiple antigenic determinants and reveal regulatory regions crucial for enzymatic activity., PMID:23182718

Increased expression of tryptophan-5-hydroxylase 1, but not 2, in brainstem as a result of intrauterine malnutrition., PMID:22819790

Neuronal serotonin regulates growth of the intestinal mucosa in mice., PMID:22609381

Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension., PMID:22525513

Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice., PMID:22330338

A novel murine model of severe pulmonary arterial hypertension., PMID:21868504

Autocrine serotonin and transforming growth factor beta 1 signaling mediates spontaneous myxomatous mitral valve disease., PMID:19301552

Predominant expression of tryptophan hydroxylase 1 mRNA in the pituitary: a postmortem study in human brain., PMID:19233335

Molecular cloning, characterization and expression of two tryptophan hydroxylase (TPH-1 and TPH-2) genes in the hypothalamus of Atlantic croaker: down-regulation after chronic exposure to hypoxia., PMID:19015006

Comparative analysis of serotonin receptor (HTR1A/HTR1B families) and transporter (slc6a4a/b) gene expression in the zebrafish brain., PMID:18839395

Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding., PMID:17973628

Phosphorylation and activation of tryptophan hydroxylase 2: identification of serine-19 as the substrate site for calcium, calmodulin-dependent protein kinase II., PMID:17727633

Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice., PMID:17622221

Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice., PMID:17256748

Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies., PMID:16581041

Influence of polysaccharide coating on the interactions of nanoparticles with biological systems., PMID:16118015

Serotonin neurons derived from rhesus monkey embryonic stem cells: similarities to CNS serotonin neurons., PMID:15246835

Effects of ovarian steroids and raloxifene on proteins that synthesize, transport, and degrade serotonin in the raphe region of macaques., PMID:15199371

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