Catalog No.
RHD00103
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
ACP5, Tartrate-resistant acid ATPase, TR-AP, TrATPase, Tartrate-resistant acid phosphatase type 5, Type 5 acid phosphatase
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P13686
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3D42
Case report: Refractory Evans syndrome in two patients with spondyloenchondrodysplasia with immune dysregulation treated successfully with JAK1/JAK2 inhibition., PMID:38347954
Macrophage expressed tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis progression., PMID:38178705
The clinical utility of TRACP-5b to monitor anti-resorptive treatments of osteoporosis., PMID:35102444
Gegen Qinlian Decoction ameliorates type 2 diabetes osteoporosis via IGFBP3/MAPK/NFATc1 signaling pathway based on cytokine antibody array., PMID:34798519
Effect of abatacept treatment on serum osteoclast-related biomarkers in patients with rheumatoid arthritis (RA): A multicenter RA ultrasound prospective cohort in Japan., PMID:34260539
Impaired 1,25 dihydroxyvitamin D3 action and hypophosphatemia underlie the altered lacuno-canalicular remodeling observed in the Hyp mouse model of XLH., PMID:34043707
A novel BAFF antagonist, BAFF-Trap, effectively alleviates the disease progression of systemic lupus erythematosus in MRL/lpr mice., PMID:33254074
Characterisation of ACP5 missense mutations encoding tartrate-resistant acid phosphatase associated with spondyloenchondrodysplasia., PMID:32214327
Clinical value of serum bone resorption markers for predicting clinical outcomes after use of bone modifying agents in metastatic bone tumors: A prospective cohort study., PMID:31846063
Lupus-like Disease in FcγRIIB-/- Mice Induces Osteopenia., PMID:31758072
Elevated levels of circulating fibroblast growth factor 23 with hypercalcemia following discontinuation of denosumab., PMID:31527321
[Spondyloenchondrodysplasia with immune dysregulation: a case report and literature review]., PMID:30078244
Vitamin D and Calcium Addition during Denosumab Therapy over a Period of Four Years Significantly Improves Lumbar Bone Mineral Density in Japanese Osteoporosis Patients., PMID:29495518
Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes metastasis-related properties via TGFβ2/TβR and CD44 in MDA-MB-231 breast cancer cells., PMID:28915803
Evaluation of Bone Turnover / Quality Markers and Bone Mineral Density in Prostate Cancer Patients Receiving Androgen Deprivation Therapy with or without Denosumab., PMID:28668858
The adipokine tartrate-resistant acid phosphatase 5a in serum correlates to adipose tissue expansion in obesity., PMID:28532220
Medication-related osteonecrosis of the jaw; what should we do as prosthodontists?, PMID:26874926
Spondyloenchondrodysplasia Due to Mutations in ACP5: A Comprehensive Survey., PMID:26951490
Three cases of spondyloenchondrodysplasia (SPENCD) with systemic lupus erythematosus: a case series and review of the literature., PMID:26854080
The X-Linked Inhibitor of Apoptosis Protein Inhibitor Embelin Suppresses Inflammation and Bone Erosion in Collagen Antibody Induced Arthritis Mice., PMID:26347311
Carbon Monoxide Inhibits Receptor Activator of NF-κB (RANKL)-Induced Osteoclastogenesis., PMID:26138885
OPG-Fc but Not Zoledronic Acid Discontinuation Reverses Osteonecrosis of the Jaws (ONJ) in Mice., PMID:25727550
Inhibition of RANKL-dependent cellular fusion in pre-osteoclasts by amiloride and a NHE10-specific monoclonal antibody., PMID:25612314
[Markers of bone metabolism in multiple myeloma patients switched from zoledronic acid to denosumab]., PMID:25501406
Tartrate-resistant acid phosphatase 5b is a potential biomarker for rheumatoid arthritis: a pilot study in Han Chinese., PMID:25131223
Effect of the hydrogen sulfide donor GYY4137 on platelet activation and microvascular thrombus formation in mice., PMID:23586391
Foreign body giant cells and osteoclasts are TRAP positive, have podosome-belts and both require OC-STAMP for cell fusion., PMID:23444125
Immunoregulatory cytokines in mouse placental extracts inhibit in vitro osteoclast differentiation of murine macrophages., PMID:23347887
Preclinical evaluation of sunitinib as a single agent in the prophylactic setting in a mouse model of bone metastases., PMID:23347638
Th17-cells in atopic dermatitis stimulate orthodontic root resorption., PMID:23279451
Bacteria-reactive immune response may induce RANKL-expressing T cells in the mouse periapical bone loss lesion., PMID:22341072
Increased bone mass in mice after single injection of anti-receptor activator of nuclear factor-kappaB ligand-neutralizing antibody: evidence for bone anabolic effect of parathyroid hormone in mice with few osteoclasts., PMID:21862583
Antibody-mediated "universal" osteoclast targeting platform using calcitonin as a model drug., PMID:21301934
Intercellular adhesion molecule-1 on synovial cells attenuated interleukin-6-induced inhibition of osteoclastogenesis induced by receptor activator for nuclear factor κB ligand., PMID:21039424
Effects of denosumab on bone turnover markers in postmenopausal osteoporosis., PMID:20839290
RANKL induces heterogeneous DC-STAMP(lo) and DC-STAMP(hi) osteoclast precursors of which the DC-STAMP(lo) precursors are the master fusogens., PMID:20039274
Osteoclast migration on phosphorylated osteopontin is regulated by endogenous tartrate-resistant acid phosphatase., PMID:19854170
IL-12 inhibits TNF-alpha induced osteoclastogenesis via a T cell-independent mechanism in vivo., PMID:19651258
Grape seed proanthocyanidin extract (GSPE) attenuates collagen-induced arthritis., PMID:19446580
Reference intervals of serum tartrate-resistant acid phosphatase type 5b activity measured with a novel assay in Japanese subjects., PMID:18470668
Significance of serum TRACP in rheumatoid arthritis., PMID:18410226
Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMB., PMID:18313864
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation., PMID:18064667
Osteoclastic activity induces osteomodulin expression in osteoblasts., PMID:17714690
Tartrate-resistant acid phosphatase as an immunohistochemical marker for inflammatory macrophages., PMID:17369130
Development and characterization of novel monoclonal antibodies against tartrate-resistant acid phosphatase 5., PMID:17203998
Molecular analysis of RANKL-independent cell fusion of osteoclast-like cells induced by TNF-alpha, lipopolysaccharide, or peptidoglycan., PMID:17171644
Evaluation of tartrate-resistant acid phosphatase (TRACP) 5b as bone resorption marker in irradiated bone metastases., PMID:16334155
Development of immunoassays for serum tartrate-resistant acid phosphatase isoform 5a., PMID:15993395
Properties and expression of human tartrate-resistant acid phosphatase isoform 5a by monocyte-derived cells., PMID:15542543
For research use only. Not for human or drug use.
