Catalog No.
RHC45305
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IHC: 1:20-1:100
Target
CO4, CPAMD2, Acidic complement C4, C4A, Complement C4-A, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P0C0L4
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3B85
Complement Activation and Hemolysis in Non-Human Primates Following Transfusion of Genetically Modified Pig Red Blood Cells., PMID:39933991
Use of brain MRI and gene expression atlases to reconstruct the pathophysiology of autoimmune neurological disorders: The proof-of-concept of NMOSD., PMID:39891565
Association of C4 Null Alleles and Persistently Low C4 in Asian Indian Patients With Systemic Lupus Erythematosus., PMID:39800843
Complement Activation Profiles Predict Clinical Outcomes in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease., PMID:39661937
CSF complement proteins are elevated in prodromal to moderate Alzheimer's disease patients and are not altered by the anti-tau antibody semorinemab., PMID:39369294
Long-Term Immunogenicity Study of an Aluminum Phosphate-Adjuvanted Inactivated Enterovirus A71 Vaccine in Children: An Extension to a Phase 2 Study., PMID:39340018
Different Complement Activation Patterns Following C5 Cleavage in MOGAD and AQP4-IgG+NMOSD., PMID:39133885
Low C4A copy numbers and higher HERV gene insertion contributes to increased risk of SLE, with absence of association with disease phenotype and disease activity., PMID:38594415
Complement Activation Is Associated With Disease Severity in Multiple Sclerosis., PMID:38354323
Rational design of antibody-like peptides for targeting the human complement fragment protein C5a., PMID:37933678
Prospects and Pitfalls of Plasma Complement C4 in Schizophrenia: Building a Better Biomarker., PMID:37734326
Potential of a bivalent vaccine for broad protection against enterovirus 71 and coxsackie virus 16 infections causing hand, foot, and mouth disease., PMID:37648607
Nanoparticulate impurities in the pharmaceutical excipient trehalose induce an early immune response., PMID:37354998
Comparative proteomic analysis of glomerular proteins in IgA nephropathy and IgA vasculitis with nephritis., PMID:37179321
A Bivalent Inactivated Vaccine Prevents Enterovirus 71 and Coxsackievirus A16 Infections in the Mongolian Gerbil., PMID:37041034
Puumala Hantavirus Infections Show Extensive Variation in Clinical Outcome., PMID:36992513
The anaphylatoxin C5a: Structure, function, signaling, physiology, disease, and therapeutics., PMID:36989901
Intranasal immunization with curdlan induce Th17 responses and enhance protection against enterovirus 71., PMID:36863926
Complement activation profiles in anti-acetylcholine receptor positive myasthenia gravis., PMID:36752022
Serum C3 complement levels predict prognosis and monitor disease activity in Guillain-Barré syndrome., PMID:36462224
Low copy numbers of complement C4 and C4A deficiency are risk factors for myositis, its subgroups and autoantibodies., PMID:36171069
Effect of difference between EV-A71 virus epidemic strain and "vaccine strain" on neutralizing antibody titer., PMID:36112355
The effects of exercise on complement system proteins in humans: a systematic scoping review., PMID:35452398
A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies., PMID:35348614
Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases., PMID:35315244
Natural antibodies and CRP drive anaphylatoxin production by urate crystals., PMID:35296708
Kinetics of Parasite-Specific Antibody and B-Cell-Associated Gene Expression in Brown Trout, Salmo trutta during Proliferative Kidney Disease., PMID:34943159
Monogenic lupus with homozygous C4A deficiency presenting as bronchiectasis and immune-mediated thrombocytopenia., PMID:34287686
Profiling Complement System Components in Primary CNS Vasculitis., PMID:34066885
Aqueous Humor Proteomic Alterations Associated with Visual Field Index Parameters in Glaucoma Patients: A Pilot Study., PMID:33808966
Emergence of a non vaccine-cognate enterovirus A71 genotype C1 in mainland China., PMID:33373653
Coagulation/Complement Activation and Cerebral Hypoperfusion in Relapsing-Remitting Multiple Sclerosis., PMID:33193314
Complement C4A Regulates Autoreactive B Cells in Murine Lupus., PMID:33147456
A case report of complement C4B deficiency in a patient with steroid and IVIG-refractory anti-NMDA receptor encephalitis., PMID:32900365
An update on the Chido/Rodgers blood group system., PMID:31935328
Complement fragments are biomarkers of antibody-mediated endothelial injury., PMID:31884386
Subvisible Particles in IVIg Formulations Activate Complement in Human Serum., PMID:31672401
DEHP Nanodroplets Leached From Polyvinyl Chloride IV Bags Promote Aggregation of IVIG and Activate Complement in Human Serum., PMID:31229435
Opposite Profiles of Complement in Antiphospholipid Syndrome (APS) and Systemic Lupus Erythematosus (SLE) Among Patients With Antiphospholipid Antibodies (aPL)., PMID:31134052
Replication and cytokine profiles of different subgenotypes of enterovirus 71 isolated from Thai patients in peripheral blood mononuclear cells., PMID:31075431
Efficient expression of enterovirus 71 based on virus-like particles vaccine., PMID:30845175
Immunogenicity, safety, cross-reaction, and immune persistence of an inactivated enterovirus A71 vaccine in children aged from two months to 11 years in Taiwan., PMID:30803843
Seroprevalence of antibodies to enterovirus 71 and coxsackievirus A16 among people of various age groups in a northeast province of Thailand., PMID:30326914
Discovery of restless legs syndrome plasmatic biomarkers by proteomic analysis., PMID:30244532
Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration., PMID:29580721
Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012-2016., PMID:29362406
A fully recombinant human IgG1 Fc multimer (GL-2045) inhibits complement-mediated cytotoxicity and induces iC3b., PMID:29296968
An inactivated hand-foot-and-mouth disease vaccine using the enterovirus 71 (C4a) strain isolated from a Korean patient induces a strong immunogenic response in mice., PMID:28542556
Laser microdissection coupled with RNA-seq reveal cell-type and disease-specific markers in the salivary gland of Sjögren's syndrome patients., PMID:28421997
HPV and systemic lupus erythematosus: a mosaic of potential crossreactions., PMID:28111707
For research use only. Not for human or drug use.
