Catalog No.
RHC43705
Species reactivity
Human, Mouse, Rat
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:100, WB: 1:500-1:1000
Target
PARP-1, Protein poly-ADP-ribosyltransferase PARP1, DNA ADP-ribosyltransferase PARP1, Poly [ADP-ribose] polymerase 1, PPOL, Poly[ADP-ribose] synthase 1, ADPRT 1, ADP-ribosyltransferase diphtheria toxin-like 1, ADPRT, PARP1, NAD(+) ADP-ribosyltransferase 1, ARTD1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P09874
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3B78
Engineered MAP30ER: A plant toxin-derived platform for EGFR-Targeted delivery of protein and chemotherapeutic payloads., PMID:40517671
177Lu-Anti-CD25 Antibody for Interleukin-2 Receptor-α-Targeted Radioimmunotherapy of SUDHL1 Lymphomas in Mice., PMID:40408541
The Poly (ADP-Ribose) Polymerase-1 Enzyme Is Overexpressed in Various Solid Canine Tumours: An Immunohistochemical Study., PMID:40177980
New therapies in pulmonary arterial hypertension: Recent insights., PMID:39991439
Exploring the role of PARP1 inhibition in enhancing antibody-drug conjugate therapy for acute leukemias: insights from DNA damage response pathway interactions., PMID:39587643
Combination strategies with PARP inhibitors in BRCA-mutated triple-negative breast cancer: overcoming resistance mechanisms., PMID:39572842
PARP1 acetylation at K119 is essential in regulating the progression and proliferation of cervical cancer cells., PMID:39400626
Gaucher-like crystal-storing histiocytosis associated with kappa chain myeloma: A case report with next generation sequencing study., PMID:39357187
Preserving ester-linked modifications reveals glutamate and aspartate mono-ADP-ribosylation by PARP1 and its reversal by PARG., PMID:38762517
CD14 facilitates perinatal human cytomegalovirus infection in biliary epithelial cells via CD55., PMID:38601478
Vesicular translocation of PARP-1 to cytoplasm causes ADP-ribosylation and disassembly of vimentin filaments during microglia activation induced by LPS., PMID:38590714
PARP Inhibitors for Breast Cancer Treatment: A Review., PMID:38512229
HBV DNA polymerase upregulates the transcription of PD-L1 and suppresses T cell activity in hepatocellular carcinoma., PMID:38475878
Phosphorylation of PP2Ac by PKC is a key regulatory step in the PP2A-switch-dependent AKT dephosphorylation that leads to apoptosis., PMID:38419089
A Knockout of Poly(ADP-Ribose) Polymerase 1 in a Human Cell Line: An Influence on Base Excision Repair Reactions in Cellular Extracts., PMID:38391916
Stimulating T cell responses against patient-derived breast cancer cells with neoantigen peptide-loaded peripheral blood mononuclear cells., PMID:38349410
From Serendipity to Intention: Development of Brain-Penetrant PARP1-Selective Inhibitors., PMID:38251977
Generation of Bispecific Antibodies by Functionalized Poly-ADP-Ribose Polymers., PMID:38147359
Targeted inhibition of the ATR/CHK1 pathway overcomes resistance to olaparib and dysregulates DNA damage response protein expression in BRCA2MUT ovarian cancer cells., PMID:38114660
PHRF1 promotes the class switch recombination of IgA in CH12F3-2A cells., PMID:37540725
Paediatric Strategy Forum for medicinal product development of DNA damage response pathway inhibitors in children and adolescents with cancer: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration., PMID:37441939
Crystalline silica-exposed human lung epithelial cells presented enhanced anchorage-independent growth with upregulated expression of BRD4 and EZH2 in autocrine and paracrine manners., PMID:37146018
Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling., PMID:37116497
Expression of Poly(Adenosine Diphosphate-Ribose) Polymerase Protein in Breast Cancer., PMID:36950213
A method for in situ visualization of Protein-Nascent RNA interactions in single cell using Proximity Ligation Assay (IPNR-PLA) in mammalian cells., PMID:36927323
An Array SPRi Biosensor for the Determination on PARP-1 in Blood Plasma., PMID:36831138
New Life of Topoisomerase I Inhibitors as Antibody-Drug Conjugate Warheads., PMID:36637483
A radioiodinated rucaparib analogue as an Auger electron emitter for cancer therapy., PMID:36621256
PARP1 controls the transcription of CD24 by ADP-ribosylating the RNA helicase DDX5 in pancreatic cancer., PMID:36584909
Chromatin Immunoprecipitation Approach to Determine How PARP1 Domains Affect Binding Pattern to Chromatin., PMID:36515842
Subcellular Quantitation of ADP-Ribosylation by High-Content Microscopy., PMID:36515832
An Enzyme-Linked Immunosorbent Assay to Quantify Poly (ADP-Ribose) Level In Vivo., PMID:36515831
Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305., PMID:36355054
Mammalian N1-adenosine PARylation is a reversible DNA modification., PMID:36253381
PARP-inhibition reprograms macrophages toward an anti-tumor phenotype., PMID:36223740
The fast-growing business of Serine ADP-ribosylation., PMID:35963141
Capturing a Pentacyclic Fragment-Based Library Derived from Perophoramidine: Their Design, Synthesis and Evaluation as Anticancer Compounds by DNA Double-Strand Breaks (DSB) and PARP-1 Inhibition., PMID:35952312
Recent Insights into PARP and Immuno-Checkpoint Inhibitors in Epithelial Ovarian Cancer., PMID:35886427
CD38: An important regulator of T cell function., PMID:35834988
A synthetic lethal strategy using PARP and ATM inhibition for overcoming trastuzumab resistance in HER2-positive cancers., PMID:35798878
Caspase-2 is a mediator of apoptotic signaling in response to gemtuzumab ozogamicin in acute myeloid leukemia., PMID:35690610
Interrogating the Significance of PARP1 Expression and PBRM1 Mutation as Biomarkers for Predicting the Response to Atezolizumab plus Bevacizumab or to Sunitinib in Patients with Clear Cell Renal Cell Carcinoma., PMID:35688666
Inducing Synergistic DNA Damage by TRIP13 and PARP1 Inhibitors Provides a Potential Treatment for Hepatocellular Carcinoma., PMID:35517402
Combining Carbon-Ion Irradiation and PARP Inhibitor, Olaparib Efficiently Kills BRCA1-Mutated Triple-Negative Breast Cancer Cells., PMID:35340889
GqPCR-stimulated dephosphorylation of AKT is induced by an IGBP1-mediated PP2A switch., PMID:34998390
Metformin and fluoxetine improve depressive-like behavior in a murine model of Parkinsońs disease through the modulation of neuroinflammation, neurogenesis and neuroplasticity., PMID:34890997
Model of Streptozotocin-nicotinamide Induced Type 2 Diabetes: a Comparative Review., PMID:34789130
The Significance of PARP1 as a biomarker for Predicting the Response to PD-L1 Blockade in Patients with PBRM1-mutated Clear Cell Renal Cell Carcinoma., PMID:34627641
Activated ERK Signaling Is One of the Major Hub Signals Related to the Acquisition of Radiotherapy-Resistant MDA-MB-231 Breast Cancer Cells., PMID:34066541
An adaptive, biomarker-directed platform study of durvalumab in combination with targeted therapies in advanced urothelial cancer., PMID:33941921
For research use only. Not for human or drug use.
