Catalog No.
RHC38404
Species reactivity
Human, Mouse
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
WB: 1:500-1:1000
Target
Oct-2, POU domain, class 2, transcription factor 2, OTF-2, OCT2, Octamer-binding protein 2, POU2F2, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, Octamer-binding transcription factor 2, OTF2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P09086
Applications
WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3B49
Increased expression of interleukin-21-inducible genes in minor salivary glands are associated with primary Sjögren's syndrome disease characteristics., PMID:33247940
Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2., PMID:26993806
MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production., PMID:23960236
B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1., PMID:23045607
CD86 stimulation on a B cell activates the phosphatidylinositol 3-kinase/Akt and phospholipase C gamma 2/protein kinase C alpha beta signaling pathways., PMID:16709832
Alterations of loci encoding PU.1, BOB1, and OCT2 transcription regulators do not correlate with their suppressed expression in Hodgkin lymphoma., PMID:15796964
Analysis of transcription factor OCT.1, OCT.2 and BOB.1 expression using tissue arrays in classical Hodgkin's lymphoma., PMID:15257313
The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombination., PMID:15252056
CD86 and beta2-adrenergic receptor signaling pathways, respectively, increase Oct-2 and OCA-B Expression and binding to the 3'-IgH enhancer in B cells., PMID:15024018
All known in vivo functions of the Oct-2 transcription factor require the C-terminal protein domain., PMID:14978099
NF-kappa B and Oct-2 synergize to activate the human 3' Igh hs4 enhancer in B cells., PMID:14707079
Critical role for the Oct-2/OCA-B partnership in Ig-secreting cells., PMID:14662861
The B-cell transcription factors BSAP, Oct-2, and BOB.1 and the pan-B-cell markers CD20, CD22, and CD79a are useful in the differential diagnosis of classic Hodgkin lymphoma., PMID:14608905
Disruption of the B-cell specific transcriptional program in HHV-8 associated primary effusion lymphoma cell lines., PMID:12592383
Primary mediastinal B-cell lymphoma: high frequency of BCL-6 mutations and consistent expression of the transcription factors OCT-2, BOB.1, and PU.1 in the absence of immunoglobulins., PMID:12507907
Differential regulation of CD36 expression in antigen-presenting cells: Oct-2 dependence in B lymphocytes but not dendritic cells or macrophages., PMID:12356675
Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease., PMID:11929801
A conserved sequence block in the murine and human T cell receptor Jalpha loci interacts with developmentally regulated nucleoprotein complexes in vitro and associates with GATA-3 and octamer-binding factors in vivo., PMID:11385613
B cell development and immunoglobulin gene transcription in the absence of Oct-2 and OBF-1., PMID:11135581
Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription., PMID:11154228
Transcriptional regulation of the human osteopontin promoter: functional analysis and DNA-protein interactions., PMID:11126367
An essential octamer motif in the mb-1 (Igalpha) promoter., PMID:11000405
An upstream Oct-1- and Oct-2-binding silencer governs B29 (Ig beta) gene expression., PMID:10679093
Binding of octamer factors to a novel 3'-positive regulatory element in the mouse interleukin-5 gene., PMID:10660628
Interaction and functional interference of C/EBPbeta with octamer factors in immunoglobulin gene transcription., PMID:10602039
Transcriptional regulation of the murine 3' IgH enhancer by OCT-2., PMID:10591177
The activity of the human interleukin-5 conserved lymphokine element 0 is regulated by octamer factors in human cells., PMID:10491186
Transcription factor effects on chromosome constitution of cell hybrids., PMID:9925930
oct-2 gene disruption eliminates the peritoneal B-1 lymphocyte lineage and attenuates B-2 cell maturation and function., PMID:9548466
Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription., PMID:9384588
Temporal control of IgH gene expression in developing B cells by the 3' locus control region., PMID:9442395
Diverse transcription factors are involved in the quantitative regulation of transcriptional activation of kappa promoters., PMID:9209478
Characterization of constitutive and inducible transcription factors binding to the P2 NF-AT site in the human interleukin-4 promoter., PMID:9133600
Decreased production of IL-2 and IFN-gamma by stimulated splenocytes from mice bearing plasma cell tumors is associated with alteration of DNA-binding factors., PMID:8982782
Octamer independent activation of transcription from the kappa immunoglobulin germline promoter., PMID:8972869
High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells., PMID:8639794
Concerted repression of an immunoglobulin heavy-chain enhancer, 3' alpha E(hs1,2)., PMID:8633077
Induction of the Oct-2 transcription factor in primary sensory neurons during inflammation is nerve growth factor-dependent., PMID:8929970
Real-time analysis of Oct protein-octamer interaction and transcription complex assembly., PMID:8643112
Role of Oct-2 in immunoglobulin gene silencing., PMID:7486513
Interaction of Oct-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter., PMID:7642649
Stimulation of basal transcription from the mouse mammary tumor virus promoter by Oct proteins., PMID:7609037
Diphosphoryl lipid A from Rhodobacter sphaeroides transiently activates NF-kappa B but inhibits lipopolysaccharide induction of kappa light chain and Oct-2 in the B-cell lymphoma line 70Z/3., PMID:7868225
A B-cell coactivator of octamer-binding transcription factors., PMID:7779176
Involvement of the Ets family factor PU.1 in the activation of immunoglobulin promoters., PMID:7822329
Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation., PMID:7600291
Constitutively expressed Oct-2 prevents immunoglobulin gene silencing in myeloma x T cell hybrids., PMID:7600290
Simultaneous activation of Ig and Oct-2 synthesis and reduction of surface MHC class II expression by IL-6., PMID:7930570
Two different IFN-gamma nonresponsive variants derived from the B-cell lymphoma 70Z/3., PMID:8039828
Genetic analysis of transcription factors implicated in B lymphocyte development., PMID:7616055
For research use only. Not for human or drug use.
