Catalog No.
RHC20206
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
CDC28A, CDKN1, P34CDC2, p34 protein kinase, CDK1, Cell division protein kinase 1, Cell division control protein 2 homolog, CDC2, Cyclin-dependent kinase 1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P06493
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2Z70
Selective but not pan-CDK inhibition abrogates 5-FU-driven tissue factor upregulation in colon cancer., PMID:38719932
The dysfunction of CD8+ T cells triggered by endometriotic stromal cells promotes the immune survival of endometriosis., PMID:38544333
Differential anti-viral response to respiratory syncytial virus A in preterm and term infants., PMID:38447274
AZD1775 and anti-PD-1 antibody synergistically sensitize hepatoma to radiotherapy., PMID:38167245
PARP Inhibitor Sensitizes BRCA-mutant Pancreatic Cancer to Oxaliplatin by Suppressing the CDK1/BRCA1 Axis., PMID:38030179
ASPP2 Is Phosphorylated by CDK1 during Mitosis and Required for Pancreatic Cancer Cell Proliferation., PMID:38001686
Mammalian cells internalize bacteriophages and use them as a resource to enhance cellular growth and survival., PMID:37883333
Genomic and immune landscape Of metastatic pheochromocytoma and paraganglioma., PMID:36854674
Coxsackievirus A6 Infection Causes Neurogenic Pathogenesis in a Neonatal Murine Model., PMID:36851724
HUSH-mediated HIV silencing is independent of TASOR phosphorylation on threonine 819., PMID:36309692
Triacylglycerol lipase Tgl4 is a stable protein and its dephosphorylation is regulated in a cell cycle-dependent manner in Saccharomyces cerevisiae., PMID:35981421
Anlotinib suppresses proliferation, migration, and immune escape of gastric cancer cells by activating the cGAS-STING/IFN-β pathway., PMID:35471977
Conserved Mitotic Phosphorylation of a Proteasome Subunit Regulates Cell Proliferation., PMID:34831298
Activation of PKM2 metabolically controls fulminant liver injury via restoration of pyruvate and reactivation of CDK1., PMID:34425230
Use of Mitotic Protein Kinase Inhibitors and Phospho-Specific Antibodies to Monitor Protein Phosphorylation During the Cell Cycle., PMID:34085225
Knockdown of SASS6 reduces growth of MDA‑MB‑231 triple‑negative breast cancer cells through arrest of the cell cycle at the G2/M phase., PMID:33907854
SOGA1 and SOGA2/MTCL1 are CLASP-interacting proteins required for faithful chromosome segregation in human cells., PMID:33587225
Cdk1 phosphorylation negatively regulates the activity of Net1 towards RhoA during mitosis., PMID:33465404
G1 Cell Cycle Arrest and Extrinsic Apoptotic Mechanisms Underlying the Anti-Leukemic Activity of CDK7 Inhibitor BS-181., PMID:33352782
Dracocephalum heterophyllum (DH) Exhibits Potent Anti-Proliferative Effects on Autoreactive CD4+ T Cells and Ameliorates the Development of Experimental Autoimmune Uveitis., PMID:33117376
Phosphorylation of Msx1 promotes cell proliferation through the Fgf9/18-MAPK signaling pathway during embryonic limb development., PMID:33080014
Proteomic Analysis of Protein Ubiquitination Events in Human Primary and Metastatic Colon Adenocarcinoma Tissues., PMID:33014840
Wolbachia increase germ cell mitosis to enhance the fecundity of Laodelphax striatellus., PMID:32966874
ULK1-ATG13 and their mitotic phospho-regulation by CDK1 connect autophagy to cell cycle., PMID:32516310
CDK1 dependent phosphorylation of hTERT contributes to cancer progression., PMID:32214089
Theileria annulata surface protein (TaSP) is a target of cyclin-dependent kinase 1 phosphorylation in Theileria annulata-infected cells., PMID:32174040
A novel BCMA PBD-ADC with ATM/ATR/WEE1 inhibitors or bortezomib induce synergistic lethality in multiple myeloma., PMID:32060401
Lung IFNAR1hi TNFR2+ cDC2 promotes lung regulatory T cells induction and maintains lung mucosal tolerance at steady state., PMID:31959883
The therapeutic effectiveness of 177Lu-lilotomab in B-cell non-Hodgkin lymphoma involves modulation of G2/M cell cycle arrest., PMID:31836849
Cell-Cycle-Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis., PMID:31253668
Involvement of Myt1 kinase in the G2 phase of the first cell cycle in Xenopus laevis., PMID:31128913
Marek's Disease Virus Regulates the Ubiquitylome of Chicken CD4+ T Cells to Promote Tumorigenesis., PMID:31035338
Synergistic efficacy of RLIP inhibition and 2'-hydroxyflavanone against DMBA-induced mammary carcinogenesis in SENCAR mice., PMID:31006917
Mitochondrial Function of CKS2 Oncoprotein Links Oxidative Phosphorylation with Cell Division in Chemoradioresistant Cervical Cancer., PMID:30856376
CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation., PMID:30765437
Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck., PMID:30755439
In vitro neutralization of autocrine IL‑10 affects Op18/stathmin signaling in non‑small cell lung cancer cells., PMID:30320402
CFP1 coordinates histone H3 lysine-4 trimethylation and meiotic cell cycle progression in mouse oocytes., PMID:30154440
Transcriptional targeting of oncogene addiction in medullary thyroid cancer., PMID:30135308
Multipronged activity of combinatorial miR-143 and miR-506 inhibits Lung Cancer cell cycle progression and angiogenesis in vitro., PMID:30002440
Cdk1 phosphorylation of the dynein adapter Nde1 controls cargo binding from G2 to anaphase., PMID:29930206
Schaftoside Interacts With NlCDK1 Protein: A Mechanism of Rice Resistance to Brown Planthopper, Nilaparvata lugens., PMID:29896209
Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase., PMID:29518391
Characterization and validation of potential therapeutic targets based on the molecular signature of patient-derived xenografts in gastric cancer., PMID:29433585
Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer., PMID:29391599
Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer., PMID:29263404
DNMT1 is associated with cell cycle and DNA replication gene sets in diffuse large B-cell lymphoma., PMID:29137822
Defective Cyclin B1 Induction in Trastuzumab-emtansine (T-DM1) Acquired Resistance in HER2-positive Breast Cancer., PMID:28821558
Prospective Review of Mesenchymal Stem Cells Differentiation into Osteoblasts., PMID:28276640
Gene expression profiling of anti-CTLA4-treated metastatic melanoma in patients with treatment-induced autoimmunity., PMID:27918555
For research use only. Not for human or drug use.
