Catalog No.
RHC19101
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
INSR, IR, CD220, Insulin receptor
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P06213
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2Z58
M2‑like tumour‑associated macrophage‑secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway., PMID:34184083
Rare causes of hypoglycemia in adults., PMID:32409005
The expression of the insulin receptor in gastric cancer correlates with the HER2 status and may have putative therapeutic implications., PMID:30989432
Glucose-Sensitive Myokine/Cardiokine MG53 Regulates Systemic Insulin Response and Metabolic Homeostasis., PMID:30586741
Oncofoetal insulin receptor isoform A marks the tumour endothelium; an underestimated pathway during tumour angiogenesis and angiostatic treatment., PMID:30559346
Combined Immunosuppressive Therapy Induces Remission in Patients With Severe Type B Insulin Resistance: A Prospective Cohort Study., PMID:30201849
Evaluation of anti-insulin receptor antibodies as potential novel therapies for human insulin receptoropathy using cell culture models., PMID:29700562
Delivery of Biologics Across the Blood-Brain Barrier with Molecular Trojan Horse Technology., PMID:29067674
Detection of Islet Cell Immune Reactivity with Low Glycemic Index Foods: Is This a Concern for Type 1 Diabetes?, PMID:28819632
Brain and Organ Uptake in the Rhesus Monkey in Vivo of Recombinant Iduronidase Compared to an Insulin Receptor Antibody-Iduronidase Fusion Protein., PMID:28279069
Diabetic Ketoacidosis Without Diabetes., PMID:27636019
Ridaforolimus (MK-8669) synergizes with Dalotuzumab (MK-0646) in hormone-sensitive breast cancer., PMID:27765027
Re-engineering therapeutic antibodies for Alzheimer's disease as blood-brain barrier penetrating bi-specific antibodies., PMID:27572805
Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes., PMID:27271189
Type B insulin resistance syndrome., PMID:27254267
A Novel Allosteric Insulin Receptor-Activating Antibody Reduces Hyperglycemia without Hypoglycemia in Diabetic Cynomolgus Monkeys., PMID:26578267
Insulin treatment promotes tyrosine phosphorylation of PKR and inhibits polyIC induced PKR threonine phosphorylation., PMID:26321373
Intrinsic Resistance to Cixutumumab Is Conferred by Distinct Isoforms of the Insulin Receptor., PMID:26263910
Insulin family polymorphisms in pregnancies complicated by small for gestational age infants., PMID:26089371
Successful pregnancy outcomes in a patient with type A insulin resistance syndrome., PMID:25472847
Insulin receptor antibody-iduronate 2-sulfatase fusion protein: pharmacokinetics, anti-drug antibody, and safety pharmacology in Rhesus monkeys., PMID:24889100
Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation., PMID:24652289
Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity., PMID:24533136
Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer., PMID:24338270
Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor., PMID:23192358
Circulating insulin-like growth factors may contribute substantially to insulin receptor isoform A and insulin receptor isoform B signalling., PMID:22982059
Correlation between gene expression of IGF-1R pathway markers and cetuximab benefit in metastatic colorectal cancer., PMID:22294722
Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier., PMID:22230573
Altered expression of insulin receptor isoforms in breast cancer., PMID:22046260
Biologic TNFα-inhibitors that cross the human blood-brain barrier., PMID:21327054
Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein., PMID:20100527
A modified protocol for efficient DNA encapsulation into pegylated immunoliposomes (PILs)., PMID:19545595
Antibody-mediated targeting of siRNA via the human insulin receptor using avidin-biotin technology., PMID:19093871
N-linked glycans of the human insulin receptor and their distribution over the crystal structure., PMID:17957771
Decline in exogenous gene expression in primate brain following intravenous administration is due to plasmid degradation., PMID:16779704
For research use only. Not for human or drug use.
