Catalog No.
RHC12802
Species reactivity
Human, Mouse, Rat, Rabbit, Monkey
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
FCM: 1:200-1:400, IF: 1:50-1:500, IHC: 1:100-1:500, WB: 1:500-1:2000
Target
ALDH-E2, Aldehyde dehydrogenase, mitochondrial, ALDM, ALDH2, ALDH class 2, ALDHI
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P05091
Applications
FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2Z01
Multi-omics unveils BCAA metabolism markers L-leucine and HMGCS1 as prognostic marker for immunotherapy efficacy in non-small cell lung cancer., PMID:40457349
Alcohol Plus Additional Risk Factors: Rodent Model of Liver Injury., PMID:39719149
PCSK9 in metabolism and diseases., PMID:39547595
Morphological and Immunocytochemical Characterization of Paclitaxel-Induced Microcells in Sk-Mel-28 Melanoma Cells., PMID:39062149
The ALDH2, IGSF9, and PRDM16 Proteins as Predictive Biomarkers for Prognosis in Breast Cancer., PMID:36639264
PD-L1 is highly expressed in ovarian cancer and associated with cancer stem cells populations expressing CD44 and other stem cell markers., PMID:36604635
Variant Allele of ALDH2, rs671, Associates with Attenuated Post-Vaccination Response in Anti-SARS-CoV-2 Spike Protein IgG: A Prospective Study in the Japanese General Population., PMID:35891198
Association of ALDH2 rs671 and MTHFR rs1801133 polymorphisms with hypertension among Hakka people in Southern China., PMID:35346052
Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast., PMID:35013309
Association between aldehyde dehydrogenase 2 gene rs671 G>A polymorphism and alcoholic liver cirrhosis in southern Chinese Hakka population., PMID:34033144
Aldehyde Dehydrogenase 2 Mediates Alcohol-Induced Colorectal Cancer Immune Escape through Stabilizing PD-L1 Expression., PMID:34026438
An Automatable Hydrogel Culture Platform for Evaluating Efficacy of Antibody-Based Therapeutics in Overcoming Chemoresistance., PMID:32028540
The biological activity of bispecific trastuzumab/pertuzumab plant biosimilars may be drastically boosted by disulfiram increasing formaldehyde accumulation in cancer cells., PMID:31700025
Potential function of CTLA-4 in the tumourigenic capacity of melanoma stem cells., PMID:30344757
Autoantibody against aldehyde dehydrogenase 2 could be a biomarker to monitor progression of Graves' orbitopathy., PMID:29397435
Transient and Prolonged Response of Chicken Cecum Mucosa to Colonization with Different Gut Microbiota., PMID:27685470
Ethanol upregulates NMDA receptor subunit gene expression in human embryonic stem cell-derived cortical neurons., PMID:26266540
Hypothesis of demodicidosis rosacea flushing etiopathogenesis., PMID:25683389
Dominance of the inactive Asian variant over activity and protein contents of mitochondrial aldehyde dehydrogenase 2 in human liver., PMID:23909789
ALDH2 protects against stroke by clearing 4-HNE., PMID:23689279
Genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among Japanese alcoholic men., PMID:23550892
Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human small intestine., PMID:23231010
Poly(ADP-ribose) polymerase inhibition prevents reactive oxygen species induced inhibition of aldehyde dehydrogenase2 activity., PMID:23159776
Characterization of rat liver proteins adducted by reactive metabolites of menthofuran., PMID:23106769
Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human large bowel: association of the functional polymorphisms of ADH and ALDH genes with hemorrhoids and colorectal cancer., PMID:21940137
Over-expression of aldehyde dehydrogenase-2 protects against H₂O₂-induced oxidative damage and apoptosis in peripheral blood mononuclear cells., PMID:21293477
Malondialdehyde inhibits an AMPK-mediated nuclear translocation and repression activity of ALDH2 in transcription., PMID:21130747
Inhibition of hepatic mitochondrial aldehyde dehydrogenase by carbon tetrachloride through JNK-mediated phosphorylation., PMID:19922789
Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human pancreas: implications for pathogenesis of alcohol-induced pancreatic injury., PMID:19382905
Inactivation of cytosolic aldehyde dehydrogenase via S-nitrosylation in ethanol-exposed rat liver., PMID:17673211
Helicobacter pylori, chronic atrophic gastritis, inactive aldehyde dehydrogenase-2, macrocytosis and multiple upper aerodigestive tract cancers and the risk for gastric cancer in alcoholic Japanese men., PMID:17295873
Inhibition of mitochondrial aldehyde dehydrogenase by nitric oxide-mediated S-nitrosylation., PMID:16242127
Expression of aldehyde dehydrogenase 2 in the normal esophageal epithelium and alcohol consumption in patients with esophageal cancer., PMID:15970497
Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism., PMID:12940444
XRCC1 and CYP2E1 polymorphisms as susceptibility factors of plasma mutant p53 protein and anti-p53 antibody expression in vinyl chloride monomer-exposed polyvinyl chloride workers., PMID:12010862
The chemistry and biological effects of malondialdehyde-acetaldehyde adducts., PMID:11391074
The retinoid X receptor response element in the human aldehyde dehydrogenase 2 promoter is antagonized by the chicken ovalbumin upstream promoter family of orphan receptors., PMID:10900149
Relationship between serum levels of anti-low-density lipoprotein-acetaldehyde-adduct antibody and aldehyde dehydrogenase 2 heterozygotes in patients with alcoholic liver injury., PMID:10235274
Binding and activation of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4., PMID:9765594
A case-control study on male hepatocellular carcinoma based on hospital and community controls., PMID:9575688
Localization of cytoplasmic and mitochondrial aldehyde dehydrogenase isozymes in human liver., PMID:3134575
Genetic polymorphism of enzymes of alcohol metabolism and susceptibility to alcoholic liver disease., PMID:3067025
Purification of human liver aldehyde dehydrogenase by high-performance liquid chromatography and identification of isoenzymes by immunoblotting., PMID:3551665
Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2., PMID:2987944
For research use only. Not for human or drug use.
