Catalog No.
RHC05403
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
cRaf, RAF proto-oncogene serine/threonine-protein kinase, RAF1, Proto-oncogene c-RAF, RAF, Raf-1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P04049
Applications
ELISA, FCM, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2Y47
Targeting RAF1 gene fusions with MEK inhibition in metastatic melanoma., PMID:39504576
Uncovering the pharmacological mechanism of Shou Tai Wan on recurrent spontaneous abortion: A integrated pharmacology strategy-based research., PMID:38104875
Toxic Epidermal Necrolysis and Stevens - Johnson Syndrome Following Sintilimab Administration in a Non-Small Cell Lung Cancer Patient: A Case Report., PMID:37936597
SARS-CoV-2 suppresses TLR4-induced immunity by dendritic cells via C-type lectin receptor DC-SIGN., PMID:37844099
Guben Xiezhuo Decoction inhibits M1 polarization through the Raf1/p-Elk1 signaling axis to attenuate renal interstitial fibrosis., PMID:37716490
Exosomal circRNA-001264 promotes AML immunosuppression through induction of M2-like macrophages and PD-L1 overexpression., PMID:37657244
Plasma microRNA-195, -34c, and - 1246 as novel biomarkers for the diagnosis of trastuzumab-resistant HER2-positive breast cancer patients., PMID:37557922
Kechuanning Gel Plaster Exerts Anti-inflammatory and Immunomodulatory Effects on Ovalbumin-induced Asthma Model Rats via ERK Pathway., PMID:37138476
Rare molecular subtypes of lung cancer., PMID:36806787
PAX5 P80R-mutated B-cell acute lymphoblastic leukemia with transformation to histiocytic sarcoma: clonal evolution assessment using NGS-based immunoglobulin clonality and mutation analysis., PMID:36241730
Dioscorea nipponica Makino Relieves Ovalbumin-Induced Asthma in Mice through Regulating RKIP-Mediated Raf-1/MEK/MAPK/ERK Signaling Pathway., PMID:35757465
Exonic variants in multiple myeloma patients associated with relapsed/ refractory and response to bortezomib regimens., PMID:35002457
A 5-Genomic Mutation Signature Can Predict the Survival for Patients With NSCLC Receiving Atezolizumab., PMID:34248926
Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT., PMID:33649826
Novel LRRFIP2-RAF1 fusion identified in an acral melanoma: A review of the literature on melanocytic proliferations with RAF1 fusions and the potential therapeutic implications., PMID:32700768
Chaperone mediated detection of small molecule target binding in cells., PMID:31974362
Cerebral ischemia-reperfusion aggravated cerebral infarction injury and possible differential genes identified by RNA-Seq in rats., PMID:31877338
MicroRNA-141-3p affected proliferation, chemosensitivity, migration and invasion of colorectal cancer cells by targeting EGFR., PMID:31704502
Role of C5b-9 and RGC-32 in Cancer., PMID:31156630
Comparison of protein expression between formalin-fixed core-cut biopsies and surgical excision specimens using a novel multiplex approach., PMID:30796652
MicroRNA-143 is Associated With Pathological Complete Response and Regulates Multiple Signaling Proteins in Breast Cancer., PMID:30755102
Modulation of vascular endothelial growth factor and mitogen-activated protein kinase-related pathway involved in extracorporeal shockwave therapy accelerate diabetic wound healing., PMID:30394625
Up-regulation of microRNA-497 inhibits the proliferation, migration and invasion but increases the apoptosis of multiple myeloma cells through the MAPK/ERK signaling pathway by targeting Raf-1., PMID:30382763
Biomarker analysis beyond angiogenesis: RAS/RAF mutation status, tumour sidedness, and second-line ramucirumab efficacy in patients with metastatic colorectal carcinoma from RAISE-a global phase III study., PMID:30339194
Effectiveness of EGFR/HER2-targeted drugs is influenced by the downstream interaction shifts of PTPIP51 in HER2-amplified breast cancer cells., PMID:30139932
Cooperative multi-targeting of signaling networks by angiomiR-204 inhibits vasculogenic mimicry in breast cancer cells., PMID:29885516
A comparative global phosphoproteomics analysis of obinutuzumab (GA101) versus rituximab (RTX) against RTX sensitive and resistant Burkitt lymphoma (BL) demonstrates differential phosphorylation of signaling pathway proteins after treatment., PMID:29371955
CX3CL1 promotes MMP-3 production via the CX3CR1, c-Raf, MEK, ERK, and NF-κB signaling pathway in osteoarthritis synovial fibroblasts., PMID:29268768
A systems medicine approach reveals disordered immune system and lipid metabolism in multiple sclerosis patients., PMID:29194580
Sorafenib stimulates human skin type mast cell degranulation and maturation., PMID:28843624
Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome., PMID:28548091
Molecular dissection of effector mechanisms of RAS-mediated resistance to anti-EGFR antibody therapy., PMID:28507280
Profiling of Signaling Proteins in Penumbra After Focal Photothrombotic Infarct in the Rat Brain Cortex., PMID:27771897
Pleurotus citrinopileatus polysaccharide induces activation of human dendritic cells through multiple pathways., PMID:27592080
Silencing Aurora-A with siRNA inhibits cell proliferation in human lung adenocarcinoma cells., PMID:27571708
Human Blood Autoantibodies in the Detection of Colorectal Cancer., PMID:27383396
A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1., PMID:27169363
Sprouty 2: a novel attenuator of B-cell receptor and MAPK-Erk signaling in CLL., PMID:26809508
Functional Analysis of the Adrenomedullin Pathway in Malignant Pleural Mesothelioma., PMID:26762744
Human Intestinal Raf Kinase Inhibitor Protein (RKIP) Catalyzes Prasugrel as a Bioactivation Hydrolase., PMID:26558823
Lapatinib increases motility of triple-negative breast cancer cells by decreasing miRNA-7 and inducing Raf-1/MAPK-dependent interleukin-6., PMID:26513016
PTPIP51 levels in glioblastoma cells depend on inhibition of the EGF-receptor., PMID:25862004
Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2., PMID:25827955
Astaxanthin and withaferin A block paracrine cytokine interactions between UVB-exposed human keratinocytes and human melanocytes via the attenuation of endothelin-1 secretion and its downstream intracellular signaling., PMID:25777483
Detecting key genes regulated by miRNAs in dysfunctional crosstalk pathway of myasthenia gravis., PMID:25705681
Role of Raf kinase inhibitor protein in Helicobacter pylori-mediated signaling in gastric cancer., PMID:25597356
MicroRNA-7 expression in colorectal cancer is associated with poor prognosis and regulates cetuximab sensitivity via EGFR regulation., PMID:25503932
The C-type lectin OCILRP2 costimulates EL4 T cell activation via the DAP12-Raf-MAP kinase pathway., PMID:25411776
Co-culture system of human salivary gland epithelial cells and immune cells from primary Sjögren's syndrome patients: an in vitro approach to study the effects of Rituximab on the activation of the Raf-1/ERK1/2 pathway., PMID:25381666
A protein with an inactive pterin-4a-carbinolamine dehydratase domain is required for Rubisco biogenesis in plants., PMID:25279696
For research use only. Not for human or drug use.
