Anti-HMGCR Antibody (R2Y44)

Catalog No.

RHC05203

Species reactivity

Human, Mouse

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

IHC: 1:50-1:100

Target

3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMGCR, HMG-CoA reductase

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P04035

Applications

IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R2Y44

Statin-associated immune-mediated necrotizing myopathy in Hispanic Americans., PMID:40446701

From cranes to crutches: the disabling potential of necrotising myopathy., PMID:40441745

Anti-HMGCR myopathy: a first case report from North Africa and literature insights., PMID:40421031

In immune-mediated necrotising myopathy, anti-HMGCR antibodies inhibit HMGCR activity, leading to the sarcoplasmic accumulation of lipid droplets and myofibres necrosis., PMID:40410054

Anti-HMGCR antibodies can be accurately detected by indirect immunofluorescence on HEp-2000 substrate., PMID:40383694

Emerging atypical clinicopathological manifestations of immune-mediated necrotizing myopathy (IMNM)., PMID:40315785

Subacute Cardiomyopathy Due to Statin Treatment: Can It Be True?-Case Report and Literature Review., PMID:40283184

Dysphagia During Pharyngeal and Esophageal Phase of Seronegative Immune-Mediated Necrotizing Myopathy: A Case Report., PMID:40264623

Effectiveness of proprotein convertase subtilisin/kexin type 9 inhibitors in managing hypercholesterolemia post-statin-associated immune-mediated necrotizing myopathy: report of five cases and literature review., PMID:40249406

Pediatric Immune-Mediated Necrotizing Myopathy: A Single-Center Retrospective Cohort Study., PMID:40203548

Clinicopathological features of anti-HMGCR and anti-SRP myopathies that do not satisfy the EULAR/ACR criteria of inflammatory myopathies., PMID:40178989

Persistent exanthema mainly on the trunk with pathologically dermal interstitial mucin as anti-HMGCR myopathy-associated skin rash: Case series., PMID:40152349

Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit., PMID:40109791

Precise identification and tracking of HMGCR-reactive CD4+ T cells in the target tissue of patients with anti-HMGCR immune-mediated necrotising myopathy., PMID:39919903

Predictive value of myositis antibodies: role of semiquantitative classification and positivity for more than one autoantibody., PMID:39837620

Applicability of a serodiagnostic line blot for idiopathic inflammatory myopathy: the muscle biopsy is not all., PMID:39835155

Therapeutic plasmapheresis as an effective treatment for refractory anti-3-hydroxy-3-methylglutaryl coenzyme A reductase-positive immune-mediated necrotising myopathy., PMID:39828311

Effects of HMG CoA reductase (HMGCR) deficiency on skeletal muscle development., PMID:39823152

Lipids, lipid-lowering drugs and the risk of herpes zoster: a Mendelian randomization study., PMID:39755897

Effectiveness and Safety of IVIG for the Treatment of HMGCR Immune-Mediated Necrotizing Myopathy., PMID:39731314

Statin-Induced Necrotizing Autoimmune Myopathy: Diagnosis and Treatment Approach., PMID:39659392

Case report: Rapid clinical improvement of anti-HMGCR immune-mediated necrotizing myopathy treated with efgartigimod., PMID:39569185

Clinicopathological and imaging differences between pediatric and adult patients with anti-hydroxy-3-methyl-glutaryl-coenzyme A reductase necrotizing myopathy., PMID:39562394

Statin-Induced Necrotizing Autoimmune Myopathy: An Uncommon yet Challenging Complication of Statin Use., PMID:39529788

[Not Available]., PMID:39534931

Pediatric case of immune-mediated necrotizing myopathy with anti-HMGCR antibodies and dermatomyositis skin rash., PMID:39511553

Treatment of refractory immune-mediated necrotizing myopathy with efgartigimod., PMID:39502686

A Case of Statin-Induced Necrotizing Autoimmune Myopathy., PMID:39493067

Immune-Mediated Necrotizing Myopathy With Anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibodies Following Viral Infection and Without Association With Statin Use: A Case Report., PMID:39463677

Involvement of erector spinae muscles in a case of systemic lupus erythematosus with anti-HMGCR antibody., PMID:39288327

Pathogenic mechanisms of disease in idiopathic inflammatory myopathies: autoantibodies as clues., PMID:39281689

The first reported familial case of statin-induced immune-mediated necrotizing myopathy associated with anti-hydroxy-3-methylglutaryl-CoA reductase autoantibodies and HLA DRB1*11:01., PMID:39279651

Association of anti-HMGCR antibodies of the IgM isotype with refractory immune-mediated necrotizing myopathy., PMID:39261921

Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy., PMID:39247442

Clinical and persistent remission in anti-HMGCR immune-mediated necrotizing myopathy to a single cycle of rituximab - a case-based review., PMID:39243358

Absence of Pathogenic Mutations and Strong Association With HLA-DRB1*11:01 in Statin-Naïve Early-Onset Anti-HMGCR Necrotizing Myopathy., PMID:39106428

Anti-HMGCR myopathy: Diversity of clinical presentations in a national cohort in New Zealand., PMID:39079206

Benefits of Early Versus Late Initiation of Intravenous Immunoglobulin in the Treatment of Patients With Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy., PMID:39054727

Distinct phenotype and prognosis of immune-mediated necrotizing myopathy based on clinical-serological-pathological classification., PMID:39029922

Diffuse Large B-cell Lymphoma Complicated with Anti-3-hydroxy-3-methylglutaryl-Coenzyme A Reductase Immune-mediated Necrotizing Myopathy., PMID:38987186

Ophthalmoparesis as an unusual manifestation of anti-3‑hydroxy-3-methyl-glutaryl-coenzyme A reductase antibody-associated myopathies., PMID:38981343

Anti-HMGCR (Hydroxy-3-Methylglutaryl-CoA Reductase) Myopathy: A Rare Cause of Proximal Muscle Weakness., PMID:38919212

Upregulated miR-146b-3p predicted rheumatoid arthritis development and regulated TNF-α-induced excessive proliferation, motility, and inflammation in MH7A cells., PMID:38902605

Management of immune-mediated necrotizing myopathy., PMID:38801022

Anti-HMGCR myopathy: estimated five-fold higher incidence in Polynesian compared with European populations in Aotearoa/New Zealand., PMID:38796685

Association of lipid-lowering drug targets with risk of cutaneous melanoma: a mendelian randomization study., PMID:38760735

Six Years Follow-Up of an 11-Year-Old Girl with Anti-HMGCR Myopathy., PMID:38759023

[Immune-Mediated Necrotizing Myopathy]., PMID:38741508

Atypical skin conditions of the neck and back as a dermal manifestation of anti-HMGCR antibody-positive myopathy., PMID:38734636

Perioperative Management of Paraneoplastic Necrotizing Myopathy in Thyroidectomy: A Case Report., PMID:38694410

Document Download

Anti-HMGCR Antibody (R2Y44).pdf