Catalog No.
RHB98203
Species reactivity
Human, Mouse, Rat
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
70 kDa lamin, Prelamin-A/C, Renal carcinoma antigen NY-REN-32, LMNA, LMN1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P02545
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2X92
Detection of Nuclear Blebbing and DNA Leakage in Mammalian Cells by Immunofluorescence., PMID:39895614
A case report of a rare genetic mutation (LMNA-C.185G>C, p.Arg62Pro) associated with dilated cardiomyopathy in a Han Chinese child., PMID:39390987
Post-COVID Myocarditis in Patients with Primary Cardiomyopathies: Diagnosis, Clinical Course and Outcomes., PMID:39202422
Hutchinson-Gilford progeria syndrome mice display accelerated arterial thrombus formation and increased platelet reactivity., PMID:39032390
A new fluorescent probe for the visualization of progerin., PMID:37979321
High-throughput Second-generation Sequencing Technology Assisted Diagnosis of Familial Partial Lipodystrophy (Type 2 Kobberling-Dunnigan Syndrome): A Case Report., PMID:37231758
Identification of monogenic variants in more than ten per cent of children without type 1 diabetes-related autoantibodies at diagnosis in the Finnish Pediatric Diabetes Register., PMID:36418577
A novel regulated network mediated by downregulation HIF1A-AS2 lncRNA impairs placental angiogenesis by promoting ANGPTL4 expression in preeclampsia., PMID:36016656
Involvement of muscle satellite cell dysfunction in neuromuscular disorders: Expanding the portfolio of satellite cell-opathies., PMID:35302338
Gene fusions and oncogenic mutations in MLH1 deficient and BRAFV600E wild-type colorectal cancers., PMID:35237889
Inhibition of Cathepsin B and SAPC Secreted by HIV-Infected Macrophages Reverses Common and Unique Apoptosis Pathways., PMID:34994563
Super-Resolution Imaging of the A- and B-Type Lamin Networks: A Comparative Study of Different Fluorescence Labeling Procedures., PMID:34638534
LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior., PMID:33605210
Lamin-Related Congenital Muscular Dystrophy Alters Mechanical Signaling and Skeletal Muscle Growth., PMID:33396724
Interleukin-6 neutralization ameliorates symptoms in prematurely aged mice., PMID:33393189
Comprehensive analysis of ALK, ROS1 and RET rearrangements in locally advanced rectal cancer., PMID:33168793
Broadening the spectrum of NTRK rearranged mesenchymal tumors and usefulness of pan-TRK immunohistochemistry for identification of NTRK fusions., PMID:32860002
Linking skeletal muscle aging with osteoporosis by lamin A/C deficiency., PMID:32479501
NTRK gene rearrangements are highly enriched in MLH1/PMS2 deficient, BRAF wild-type colorectal carcinomas-a study of 4569 cases., PMID:31792356
Genomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients., PMID:31653970
c-Fos separation from Lamin A/C by GDF15 promotes colon cancer invasion and metastasis in inflammatory microenvironment., PMID:31613004
Colonic Adenocarcinomas Harboring NTRK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 16 Cases and Review of the Literature., PMID:31567189
Quantification of the Lamin A/C Transcript Variants in Cancer Cell Lines by Targeted Absolute Quantitative Proteomics and Correlation with mRNA Expression., PMID:30999625
Expression of lamin A/C protein in degenerated human intervertebral disc., PMID:30536301
Elevated TGF β2 serum levels in Emery-Dreifuss Muscular Dystrophy: Implications for myocyte and tenocyte differentiation and fibrogenic processes., PMID:29693488
Biomechanical defects and rescue of cardiomyocytes expressing pathologic nuclear lamins., PMID:29432544
Low lamin A expression in lung adenocarcinoma cells from pleural effusions is a pejorative factor associated with high number of metastatic sites and poor Performance status., PMID:28806747
Lamin A and microtubules collaborate to maintain nuclear morphology., PMID:28557611
Super-SILAC mix coupled with SIM/AIMS assays for targeted verification of phosphopeptides discovered in a large-scale phosphoproteome analysis of hepatocellular carcinoma., PMID:28192239
Nuclear envelope localization of LEMD2 is developmentally dynamic and lamin A/C dependent yet insufficient for heterochromatin tethering., PMID:28056360
Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice., PMID:27916986
FHL1B Interacts with Lamin A/C and Emerin at the Nuclear Lamina and is Misregulated in Emery-Dreifuss Muscular Dystrophy., PMID:27911330
LMNA missense mutations causing familial partial lipodystrophy do not lead to an accumulation of prelamin A., PMID:27841971
Circulation autoantibody against Lamin A/C in patients with Sjögren's syndrome., PMID:27835913
ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene., PMID:27131347
Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes., PMID:27145372
Identification of shorter length lamin A protein in mouse ear cartilage tissue., PMID:26204409
Disruption of the lamin A and matrin-3 interaction by myopathic LMNA mutations., PMID:25948554
Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins., PMID:25823658
Tissue inhibitors of matrix metalloproteinases in serum are cardiac biomarkers in Emery-Dreifuss muscular dystrophy., PMID:25563468
Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal stem cell., PMID:24753226
Generation and characterization of a rat monoclonal antibody against the RNA polymerase protein from Dengue Virus-2., PMID:24063571
The muscle dystrophy-causing ΔK32 lamin A/C mutant does not impair the functions of the nucleoplasmic lamin-A/C-LAP2α complex in mice., PMID:23444379
Modeling of lamin A/C mutation premature cardiac aging using patient‐specific induced pluripotent stem cells., PMID:23362510
Phosphorylation of connexin43 on S279/282 may contribute to laminopathy-associated conduction defects., PMID:23261543
A truncated lamin A in the Lmna -/- mouse line: implications for the understanding of laminopathies., PMID:22895093
Altered chromatin organization and SUN2 localization in mandibuloacral dysplasia are rescued by drug treatment., PMID:22706480
Mutations in the Lamin A/C gene mimic arrhythmogenic right ventricular cardiomyopathy., PMID:22199124
Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma., PMID:22005913
Discordant gene expression signatures and related phenotypic differences in lamin A- and A/C-related Hutchinson-Gilford progeria syndrome (HGPS)., PMID:21738662
For research use only. Not for human or drug use.
