Catalog No.
RHB91301
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
LDLR, Low-density lipoprotein receptor, LDL receptor
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P01130
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2X15
IL-18 inhibition enlarges lesions, necrotic cores and thickens fibrous caps in Jak2 V617F clonal hematopoiesis-driven atherosclerosis., PMID:40501724
cDC1s Promote Atherosclerosis via Local Immunity and Are Targetable for Therapy., PMID:40444360
Functionalized Boron Carbide Nanoparticles as Active Boron Delivery Agents Dedicated to Boron Neutron Capture Therapy., PMID:40438187
Ertugliflozin attenuates atherosclerosis in nondiabetic ApoE-/- mice by upregulating ABCA1 and LDLR via the PPARγ/LXRα pathway., PMID:40419168
Glofitamab in refractory or relapsed diffuse large B cell lymphoma after failing CAR-T cell therapy: a phase 2 LYSA study., PMID:40181090
Targeting PCSK9 beyond the liver: evidence from experimental and clinical studies., PMID:40110803
Dramatic response to Evinacumab in a North Indian girl with homozygous familial hypercholesterolemia., PMID:40022592
Emerging roles of PCSK9 in kidney disease: lipid metabolism, megalin regulation and proteinuria., PMID:39964484
Therapeutic PCSK9 targeting: Inside versus outside the hepatocyte?, PMID:39947256
In Situ Self-Assembly of Artificial Topological Nanostructures Enhances In Vivo Efficacy of PCSK9 Inhibitory Peptides., PMID:39945488
Resistance to conventional drug therapy and good response to lomitapide allowed the identification of a novel bi-allelic semi-dominant monogenic HoFH: a case report., PMID:39931866
Isolation of PCSK9-specific nanobodies from synthetic libraries using a combined protein selection strategy., PMID:39875480
Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis., PMID:39813006
Evaluating the effect of the antiPCSK9 vaccine on systemic inflammation and oxidative stress in an experimental mouse model., PMID:39776050
Homozygous Familial Hypercholesterolemia Treatment: New Developments., PMID:39751968
Low-density Lipoprotein Receptor is an important host factor in flaviviral entry and replication in neurons., PMID:39689643
Structure of apolipoprotein B100 bound to the low-density lipoprotein receptor., PMID:39663455
Targeting LDL aggregation decreases atherosclerotic lipid burden in a humanized mouse model of familial hypercholesterolemia: Crucial role of ApoB100 conformational stabilization., PMID:39547850
PCSK9 in metabolism and diseases., PMID:39547595
Inflammatory crosstalk impairs phagocytic receptors and aggravates atherosclerosis in clonal hematopoiesis in mice., PMID:39531316
Therapeutic effects of FGF21 mimetic bFKB1 on MASH and atherosclerosis in Ldlr-/-.Leiden mice., PMID:39463193
Natural phytochemicals as small-molecule proprotein convertase subtilisin/kexin type 9 inhibitors., PMID:39421488
Prevalence of HCV HVR1 insertions and their role in antibody evasion., PMID:39378413
Visualizing Immune Checkpoint Inhibitors Derived Inflammation in Atherosclerosis., PMID:39328090
Outcome of patients with large B-cell lymphoma treated with tafasitamab plus lenalidomide either before or after CAR T-cell therapy., PMID:39163620
Proprotein convertase subtilisin/kexin type 9 deficiency in extrahepatic tissues: emerging considerations., PMID:39139638
IL-1β Induces LDL Transcytosis by a Novel Pathway Involving LDLR and Rab27a., PMID:38989581
Biparatopic anti-PCSK9 antibody enhances the LDL-uptake in HepG2 cells., PMID:38961200
The Efficacy of Tafolecimab in Chinese Patients with Hypercholesterolemia: A Systematic Review and Meta-analysis., PMID:38913274
Development of a PCSK9-targeted nanoparticle vaccine to effectively decrease the hypercholesterolemia., PMID:38897173
The role of PCSK9 in heart failure and other cardiovascular diseases-mechanisms of action beyond its effect on LDL cholesterol., PMID:38886277
Evinacumab: Mechanism of action, clinical, and translational science., PMID:38845393
The low-density lipoprotein receptor and apolipoprotein E associated with CCHFV particles mediate CCHFV entry into cells., PMID:38806525
Targeting PCSK9 as a key player in lipid metabolism: exploiting the therapeutic and biosensing potential of aptamers., PMID:38796450
A screen for Plasmodium falciparum sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host-pathogen interactions., PMID:38755636
Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability-Brief Report., PMID:38695172
PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury., PMID:38657842
PCSK9 inhibitors: a patent review 2018-2023., PMID:38588538
Evolocumab Treatment in Pediatric Patients With Homozygous Familial Hypercholesterolemia: Pooled Data From Three Open-Label Studies., PMID:38545781
Potential use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition and prevention method in viral infection., PMID:38528584
Porcine low-density lipoprotein receptor plays an important role in classical swine fever virus infection., PMID:38514916
PCSK9 inhibition protects mice from food allergy., PMID:38471633
Marginal zone B cells produce 'natural' atheroprotective IgM antibodies in a T cell-dependent manner., PMID:38381113
Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis., PMID:38362011
Model-Informed Dose Selection for a Novel Human Immunoglobulin G4 Derived Monoclonal Antibody Targeting Proprotein Convertase Kwashiorkor Type 9: Insights from Population Pharmacokinetics-Pharmacodynamics and Systems Pharmacology., PMID:38357287
LDLR is used as a cell entry receptor by multiple alphaviruses., PMID:38245515
LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus., PMID:38182887
Pseudorabies virus upregulates low-density lipoprotein receptors to facilitate viral entry., PMID:38054618
Identification of benzothiazoles as novel PCSK9 inhibitors., PMID:37939861
For research use only. Not for human or drug use.
