Catalog No.
RHB88503
Species reactivity
Human
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
IP: 1:100-1:200, WB: 1:500-1:1000
Target
Properdin factor B, Complement factor B, GBG, Glycine-rich beta glycoprotein, BFD, C3/C5 convertase, CFB, PBF2, BF
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P00751
Applications
IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2W86
TLR7 responses in glomerular macrophages accelerate the progression of glomerulonephritis in NZBWF1 mice., PMID:40401698
A non-invasive model for diagnosis of primary Sjogren's disease based on salivary biomarkers, serum autoantibodies, and Schirmer's test., PMID:39695856
[Comparative characteristics of the complement system in patients with C3-glomerulopathy and atypical hemolytic uremic syndrome of chronic course who suffered an acute episode of thrombotic microangiopathy]., PMID:38158966
Atypical hemolytic uremic syndrome: genetically-based insights into pathogenesis through an analysis of the complement regulator CD46., PMID:39949759
Alternative Complement Pathway Inhibition by Lampalizumab: Analysis of Data From Chroma and Spectri Phase III Clinical Trials., PMID:37228694
A Phase I, Single Ascending Dose Study of GEM103 (Recombinant Human Complement Factor H) in Patients with Geographic Atrophy., PMID:36249705
Systematic review of atypical hemolytic uremic syndrome biomarkers., PMID:35118546
Serum complement factor B is associated with disease activity and progression of idiopathic membranous nephropathy concomitant with IgA nephropathy., PMID:34585312
Analysis of plasma protein biomarkers in childhood onset multiple sclerosis., PMID:32841722
Alternative complement pathway is activated in the brains of scrapie-infected rodents., PMID:31720785
Discovery and Development of the Oral Complement Factor D Inhibitor Danicopan (ACH-4471)., PMID:31573880
Magnetized Carbon Nanotube Based Lateral Flow Immunoassay for Visual Detection of Complement Factor B., PMID:31366012
CFH and CFB mutations in Shiga toxin-associated haemolytic uraemic syndrome in a 6-year-old boy., PMID:31242818
Serum Exosomes from Newborn Piglets Restrict Porcine Epidemic Diarrhea Virus Infection., PMID:30983354
Mass spectrometry-based analysis of cerebrospinal fluid from arthritis patients-immune-related candidate proteins affected by TNF blocking treatment., PMID:30770760
Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models., PMID:29450541
Association between CFH, CFB, ARMS2, SERPINF1, VEGFR1 and VEGF polymorphisms and anatomical and functional response to ranibizumab treatment in neovascular age-related macular degeneration., PMID:28926193
Complement Dependence of Murine Costimulatory Blockade-Resistant Cellular Cardiac Allograft Rejection., PMID:28444847
Rare genetic variant in the CFB gene presenting as atypical hemolytic uremic syndrome and immune complex diffuse membranoproliferative glomerulonephritis, with crescents, successfully treated with eculizumab., PMID:28210841
Protein profiling in serum after traumatic brain injury in rats reveals potential injury markers., PMID:27591967
Regulation of C3 Activation by the Alternative Complement Pathway in the Mouse Retina., PMID:27564415
NETosing Neutrophils Activate Complement Both on Their Own NETs and Bacteria via Alternative and Non-alternative Pathways., PMID:27148258
Testing the Activity of Complement Convertases in Serum/Plasma for Diagnosis of C4NeF-Mediated C3 Glomerulonephritis., PMID:27146825
The C-terminal tail of polycystin-1 regulates complement factor B expression by signal transducer and activator of transcription 1., PMID:26984954
TNF Regulates Essential Alternative Complement Pathway Components and Impairs Activation of Protein C in Human Glomerular Endothelial Cells., PMID:26673143
The role of ADAMTS-13 activity and complement mutational analysis in differentiating acute thrombotic microangiopathies., PMID:26559391
[Atypical HUS caused by complement-related abnormalities]., PMID:25765799
Lack of clinical manifestations in asymptomatic dengue infection is attributed to broad down-regulation and selective up-regulation of host defence response genes., PMID:24727912
Proteomic profiling of secreted proteins for the hematopoietic support of interleukin-stimulated human umbilical vein endothelial cells., PMID:23031318
Preliminary proteomic-based identification of a novel protein for Down's syndrome in maternal serum., PMID:22678011
Atypical hemolytic uremic syndrome in children: complement mutations and clinical characteristics., PMID:22410797
Genetic association with response to intravitreal ranibizumab in patients with neovascular AMD., PMID:21282580
Cataract surgery induces retinal pro-inflammatory gene expression and protein secretion., PMID:20720227
aHUS caused by complement dysregulation: new therapies on the horizon., PMID:20556434
For research use only. Not for human or drug use.
