Catalog No.
YHD19401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys266-Gln459
Predicted molecular weight
23.71 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P16871
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL7R, Interleukin-7 receptor subunit alpha, IL-7R-alpha, IL-7 receptor subunit alpha, CD127, CDw127, IL-7R subunit alpha, IL-7RA
Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function. PMID: 29911570
Human leukocyte antigen-G and regulatory T cells during specific immunotherapy for pollen allergy. PMID: 24022071
[Ever more humanized mice for new therapeutic applications]. PMID: 25388574
CD25-expressing B-lymphocytes in rheumatic diseases. PMID: 17257224
Lower proportions of CD4+CD25(high) and CD4+FoxP3, but not CD4+CD25+CD127(low) FoxP3+ T cell levels in children with autoimmune thyroid diseases. PMID: 23249428
Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivo. PMID: 19748990
Differential reconstitution of T cell subsets following immunodepleting treatment with alemtuzumab (anti-CD52 monoclonal antibody) in patients with relapsing-remitting multiple sclerosis. PMID: 24198283
Circulating follicular regulatory T cells could inhibit Ig production in a CTLA-4-dependent manner but are dysregulated in ulcerative colitis. PMID: 31442916
Production of IgG2 Antibodies to Pneumococcal Polysaccharides After Vaccination of Treated HIV Patients May Be Augmented by IL-7Ralpha Signaling in ICOS(+) Circulating T Follicular-Helper Cells. PMID: 31068934
Blockade of IL-7Rα alleviates collagen-induced arthritis via inhibiting Th1 cell differentiation and CD4+ T cell migration. PMID: 27736699
Rhesus monkey immature monocyte-derived dendritic cells generate alloantigen-specific regulatory T cells from circulating CD4+CD127-/lo T cells. PMID: 19898200
A systematic meta-analysis of immune signatures in patients with COVID-19. PMID: 34260780
Adalimumab specifically induces CD3(+) CD4(+) CD25(high) Foxp3(+) CD127(-) T-regulatory cells and decreases vascular endothelial growth factor plasma levels in refractory immuno-mediated uveitis: a non-randomized pilot intervention study. PMID: 22222264
TLR9 signalling in HCV-associated atypical memory B cells triggers Th1 and rheumatoid factor autoantibody responses. PMID: 31279905
Successful treatment for West syndrome with severe combined immunodeficiency. PMID: 24534054
Anti-CD33 chimeric antigen receptor targeting of acute myeloid leukemia. PMID: 25480499
Monoclonal antibodies to the common gamma-chain as cytokine receptor antagonists in vivo: effect on intrathymic and intestinal intraepithelial T lymphocyte development. PMID: 9620654
IL-7 receptor blockade inhibits IL-17-producing gammadelta cells and suppresses melanoma development. PMID: 24619454
High soluble IL-7 receptor expression in Sjogren's syndrome identifies patients with increased immunopathology and dryness. PMID: 27269297
IL-7 receptor alpha blockade, an off-switch for autoreactive T cells. PMID: 22826232
Large-scale Isolation of Highly Pure "Untouched" Regulatory T Cells in a GMP Environment for Adoptive Cell Therapy. PMID: 26049548
Egg-specific IgE and basophil activation but not egg-specific T-cell counts correlate with phenotypes of clinical egg allergy. PMID: 29518422
Combining anti-IL-7Ralpha antibodies with autoantigen-specific immunotherapy enhances non-specific cytokine production but fails to prevent Type 1 Diabetes. PMID: 30908554
Preoperative carfilzomib and lulizumab based desensitization prolongs graft survival in a sensitized non-human primate model. PMID: 32898569
Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells. PMID: 28746881
Upregulated thymic stromal lymphopoietin receptor expression in children with asthma. PMID: 26999524
The miR-15 family reinforces the transition from proliferation to differentiation in pre-B cells. PMID: 28705801
IL-7-dependent homeostatic proliferation in the presence of a large number of T cells in gld mice. PMID: 15215622
Tezepelumab as an Emerging Therapeutic Option for the Treatment of Severe Asthma: Evidence to Date. PMID: 33536746
Interferon beta treatment of multiple sclerosis increases serum interleukin-7. PMID: 24821684
Anti-IL-7 receptor-alpha treatment ameliorates newly established Sjogren's-like exocrinopathy in non-obese diabetic mice. PMID: 29680668
The hepatitis B vaccine protects re-exposed health care workers, but does not provide sterilizing immunity. PMID: 23916846
Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia. PMID: 29535426
Glomerular common gamma chain confers B- and T-cell-independent protection against glomerulonephritis. PMID: 28111009
Guiding postablative lymphocyte reconstitution as a route toward transplantation tolerance. PMID: 24840180
Altered phenotype and functionality of varicella zoster virus-specific cellular immunity in individuals with active infection. PMID: 25180236
CD20+ B cell depletion alters T cell homing. PMID: 24696233
Ex vivo Stimulation of Lymphocytes with IL-10 Mimics Sepsis-Induced Intrinsic T-Cell Alterations. PMID: 29182416
Increased proportions of functionally impaired regulatory T cell subsets in systemic sclerosis. PMID: 28522286
Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo. PMID: 27199430
Membrane progesterone receptors in human regulatory T cells: a reality in pregnancy. PMID: 25639501
Type 1 innate lymphoid cell aggravation of atherosclerosis is mediated through TLR4. PMID: 29570822
Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes. PMID: 28844471
Innate IFN-γ-Producing Cells Developing in the Absence of IL-2 Receptor Common γ-Chain. PMID: 28687660
Cytomegalovirus Encephalitis in a Patient with Severe Combined Immunodeficiency. PMID: 26546317
For research use only. Not for human or drug use.
