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Anti-NR1I2 Antibody (R2V71)

Catalog #:   RHB21702 Specific References (39) DATASHEET
Host species: Mouse
Isotype: IgG2b
Applications: ELISA, FCM, IF
Accession: O75469
Overview

Catalog No.

RHB21702

Species reactivity

Human

Host species

Mouse

Isotype

IgG2b

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000

Target

NR1I2, SXR, PXR, Steroid and xenobiotic receptor, Orphan nuclear receptor PXR, Nuclear receptor subfamily 1 group I member 2, Pregnane X receptor, Orphan nuclear receptor PAR1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O75469

Applications

ELISA, FCM, IF

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R2V71

Data Image
  • Flow Cytometry
    Flow cytometric analysis of HepG2 cells using NR1I2 mouse mAb (green) and negative control (red).
  • Immunofluorescence
    Immunofluorescence analysis of Hela cells using NR1I2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
References

Multimodal sequencing of neoadjuvant nivolumab treatment in hepatocellular carcinoma reveals cellular and molecular immune landscape for drug response., PMID:40205519

Adenosine N6-methylation upregulates the expression of human CYP2B6 by altering the chromatin status., PMID:36113565

Transcription Factors and Regulators Pathway-focused Genes Expression Analysis in Patients with Different Forms of Thyroid Pathology., PMID:35176984

Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo., PMID:34386326

IL-6 downregulates hepatic carboxylesterases via NF-κB activation in dextran sulfate sodium-induced colitis., PMID:34217990

Derivation of a Human In Vivo Benchmark Dose for Perfluorooctanoic Acid From ToxCast In Vitro Concentration-Response Data Using a Computational Workflow for Probabilistic Quantitative In Vitro to In Vivo Extrapolation., PMID:34045957

The influence of the long-term chemical activation of the nuclear receptor pregnane X receptor (PXR) on liver carcinogenesis in mice., PMID:33398415

Enrichment-free High-throughput Liquid Chromatography-Multiple-Reaction Monitoring Quantification of Cytochrome P450 Proteins in Plated Human Hepatocytes Direct from 96-Well Plates Enables Routine Protein Induction Measurements., PMID:32350061

Activation of PXR by alantolactone ameliorates DSS-induced experimental colitis via suppressing NF-κB signaling pathway., PMID:31719637

DNA elements for constitutive androstane receptor- and pregnane X receptor-mediated regulation of bovine CYP3A28 gene., PMID:30908543

Effect of tacrolimus dispositional genetics on acute rejection in the first 2 weeks and estimated glomerular filtration rate in the first 3 months following kidney transplantation., PMID:30489455

Exploring genetic and non-genetic risk factors for delayed graft function, acute and subclinical rejection in renal transplant recipients., PMID:27334415

Pregnane X Receptor Represses HNF4α Gene to Induce Insulin-Like Growth Factor-Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells., PMID:26232425

Genetic polymorphism in ATG16L1 gene influences the response to adalimumab in Crohn's disease patients., PMID:25712183

Genome-wide discovery of drug-dependent human liver regulatory elements., PMID:25275310

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4., PMID:25065623

Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis., PMID:24368568

Nitric oxide and interleukin-1β stimulate the proteasome-independent degradation of the retinoic acid hydroxylase CYP2C22 in primary rat hepatocytes., PMID:24144795

Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-κB signaling pathway., PMID:23536316

Renal efflux transporter expression in pregnant mice with Type I diabetes., PMID:22531820

Clinical significance of steroid and xenobiotic receptor and its targeted gene CYP3A4 in human prostate cancer., PMID:22050110

B-1 cell lymphoma in mice lacking the steroid and xenobiotic receptor, SXR., PMID:21436254

Changes of organic anion transporter MRP4 and related nuclear receptors in human obstructive cholestasis., PMID:21359593

The suitability of rat hepatoma cell line H4IIE for evaluating the potentials of compounds to induce CYP3A23 expression., PMID:21146967

Functional role of phospholipase D (PLD) in di(2-ethylhexyl) phthalate-induced hepatotoxicity in Sprague-Dawley rats., PMID:20954081

Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver., PMID:19562681

Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice., PMID:19407337

Role of FoxO1 activation in MDR1 expression in adriamycin-resistant breast cancer cells., PMID:18390843

CYP2C75-involved autoinduction of metabolism in rhesus monkeys of methyl 3-chloro-3'-fluoro-4'-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]ethyl}-1,1'-biphenyl-2-carboxylate (MK-0686), a bradykinin B1 receptor antagonist., PMID:18310472

Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines., PMID:17279585

Purification of full-length human pregnane and xenobiotic receptor: polyclonal antibody preparation for immunological characterization., PMID:16246268

Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT)., PMID:16219912

Hepatic cytochrome P450 gene regulation during endotoxin-induced inflammation in nuclear receptor knockout mice., PMID:15860574

Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver., PMID:15347657

Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor., PMID:14978251

Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis., PMID:12883478

Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism., PMID:12756208

Induction of CYP2C genes in human hepatocytes in primary culture., PMID:11181490

Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats., PMID:10640517

Datasheet

Document Download

Anti-NR1I2 Antibody (R2V71).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-NR1I2 Antibody (R2V71) [RHB21702]
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