Catalog No.
RHB21303
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
Endoplasmic reticulum-to-nucleus signaling 1, IRE1a, ERN1, Ire1-alpha, hIRE1p, Serine/threonine-protein kinase/endoribonuclease IRE1, Inositol-requiring protein 1, IRE1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O75460
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2V70
The IRE1α/XBP1 pathway sustains cytokine responses of group 3 innate lymphoid cells in inflammatory bowel disease., PMID:38722686
The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU., PMID:38608921
Tumorous IRE1α facilitates CD8+T cells-dependent anti-tumor immunity and improves immunotherapy efficacy in melanoma., PMID:38291473
Platelets induce endoplasmic reticulum stress in macrophages in vitro., PMID:38278417
Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown., PMID:38071801
A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation., PMID:36685499
Endoplasmic Reticulum Homeostasis Regulates TLR4 Expression and Signaling in Mast Cells., PMID:36233127
Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation., PMID:35446348
Prostaglandin E2-Induced AKT Activation Regulates the Life Span of Short-Lived Plasma Cells by Attenuating IRE1α Hyperactivation., PMID:35379745
Macrophage-Derived Immunoglobulin M Inhibits Inflammatory Responses via Modulating Endoplasmic Reticulum Stress., PMID:34831038
Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer., PMID:34493732
The unfolded protein response and apoptotic regulation in the human placenta due to maternal cigarette smoking and pre-eclampsia., PMID:34492309
Inhibition of IRE1/JNK pathway in HK-2 cells subjected to hypoxia-reoxygenation attenuates mesangial cells-derived extracellular matrix production., PMID:33043579
Understanding the Role of the Unfolded Protein Response Sensor IRE1 in the Biology of Antigen Presenting Cells., PMID:31817075
Endoplasmic Reticulum Stress Markers and Their Possible Implications in Leprosy's Pathogenesis., PMID:30647798
Inhibition of Human Dendritic Cell ER Stress Response Reduces T Cell Alloreactivity Yet Spares Donor Anti-tumor Immunity., PMID:30574153
New Hope for Pancreatic Ductal Adenocarcinoma Treatment Targeting Endoplasmic Reticulum Stress Response: A Systematic Review., PMID:30134550
Inhibition of GRP78 abrogates radioresistance in oropharyngeal carcinoma cells after EGFR inhibition by cetuximab., PMID:29232380
Imiquimod-induced autophagy is regulated by ER stress-mediated PKR activation in cancer cells., PMID:28601430
Lipin-1 regulation of phospholipid synthesis maintains endoplasmic reticulum homeostasis and is critical for triple-negative breast cancer cell survival., PMID:28347999
Molecular signal networks and regulating mechanisms of the unfolded protein response., PMID:28070992
Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress., PMID:27554968
Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1α-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells., PMID:26549806
Bevacizumab induces A549 cell apoptosis through the mechanism of endoplasmic reticulum stress in vitro., PMID:26191230
The Endoplasmic Reticulum Stress Sensor Inositol-Requiring Enzyme 1α Augments Bacterial Killing through Sustained Oxidant Production., PMID:26173697
PPARβ/δ Agonist Provides Neuroprotection by Suppression of IRE1α-Caspase-12-Mediated Endoplasmic Reticulum Stress Pathway in the Rotenone Rat Model of Parkinson's Disease., PMID:26160761
Anti-dsDNA antibodies induce inflammation via endoplasmic reticulum stress in human mesangial cells., PMID:26040555
RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions., PMID:25476903
Deficiency of IRE1 and PERK signal pathways in systemic lupus erythematosus., PMID:25226532
High epiregulin expression in human U87 glioma cells relies on IRE1α and promotes autocrine growth through EGF receptor., PMID:24330607
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α., PMID:22510886
Chikungunya virus-induced autophagy delays caspase-dependent cell death., PMID:22508836
IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level., PMID:20885949
Nitric oxide induction of IRE1-alpha-dependent CREB phosphorylation in human glioma cells., PMID:20447464
Phospholipolyzed LDL induces an inflammatory response in endothelial cells through endoplasmic reticulum stress signaling., PMID:20430794
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha., PMID:19328063
For research use only. Not for human or drug use.
