Catalog No.
RHA28101
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000
Target
SAPKK4, JNK-activating kinase 2, MAPK/ERK kinase 7, MAPKK 7, c-Jun N-terminal kinase kinase 2, JNKK2, SAPK kinase 4, MEK 7, MAP kinase kinase 7, SKK4, PRKMK7, Dual specificity mitogen-activated protein kinase kinase 7, Stress-activated protein kinase kinase 4, JNK kinase 2, MKK7, MAP2K7, MEK7, JNKK 2, SAPKK-4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O14733
Applications
ELISA, FCM, IF, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2T85
The EEF1AKMT3/MAP2K7/TP53 axis suppresses tumor invasiveness and metastasis in gastric cancer., PMID:35753528
Stress-activated kinase pathway alteration is a frequent event in bladder cancer., PMID:22154358
Defective anchoring of JNK1 in the cytoplasm by MKK7 in Jurkat cells is associated with resistance to Fas-mediated apoptosis., PMID:21148294
Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia., PMID:17440097
JNK regulates MCP-1 expression in adenovirus type 19-infected human corneal fibroblasts., PMID:16186362
RACK1 mediates activation of JNK by protein kinase C [corrected]., PMID:16061178
Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho., PMID:15753034
Negative regulation of JNK signaling by the tumor suppressor CYLD., PMID:15496400
ORF36 protein kinase of Kaposi's sarcoma herpesvirus activates the c-Jun N-terminal kinase signaling pathway., PMID:15247271
Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK., PMID:13130464
Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells., PMID:12637505
Mitogen-activated protein kinases and nuclear factor-kappaB regulate Helicobacter pylori-mediated interleukin-8 release from macrophages., PMID:12150710
MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines., PMID:11390361
c-Jun NH2-terminal kinase activation leads to a FADD-dependent but Fas ligand-independent cell death in Jurkat T cells., PMID:11106658
The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity., PMID:10506143
The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes., PMID:9815259
Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli., PMID:9535930
Selective activation of JNK/SAPK by interleukin-1 in rabbit liver is mediated by MKK7., PMID:9414114
For research use only. Not for human or drug use.
