Anti-SOCS3 Antibody (R2T72)

Catalog No.

RHA21802

Species reactivity

Human

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000

Target

Cytokine-inducible SH2 protein 3, CIS-3, SSI-3, Suppressor of cytokine signaling 3, CIS3, STAT-induced STAT inhibitor 3, SSI3, SOCS3, SOCS-3

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O14543

Applications

ELISA, FCM, IF, IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R2T72

Long-term nucleus basalis cholinergic lesions alter the structure of cortical vasculature, astrocytic density and microglial activity in Wistar rats., PMID:40121723

ROS-dependent SOCS3 upregulation disrupts regulatory T cell stability during autoimmune disease development., PMID:40090133

Borrelia burgdorferi sensu lato inhibits CIITA transcription through pSTAT3 activation and enhanced SOCS1 and SOCS3 expression leading to limited IFN-γ production., PMID:39879745

Aerosol inhalation of rhIL-10 improves acute lung injury in mice by affecting pulmonary neutrophil phenotypes through neutrophil-platelet aggregates., PMID:39778276

Resolution of acute inflammation induced by monosodium urate crystals (MSU) through neutrophil extracellular trap-MSU aggregate-mediated negative signaling., PMID:39605016

Single-cell transcriptome analysis of the early immune response in the lymph nodes of Borrelia burgdorferi-infected mice., PMID:39306236

TLR4/TNFR1 blockade suppresses STAT1/STAT3 expression and increases SOCS3 expression in modulation of LPS-induced macrophage responses., PMID:39126792

Intestinal mRNA expression profiles associated with mucosal healing in ustekinumab-treated Crohn's disease patients: bioinformatics analysis and prospective cohort validation., PMID:38926732

Differential anti-viral response to respiratory syncytial virus A in preterm and term infants., PMID:38447274

Identification of Hit Compounds Using Artificial Intelligence for the Management of Allergic Diseases., PMID:38396957

Endogenous blocking of TLR2 along with TNF-α and IL-1β ameliorates the severity of the S. aureus arthritis via modulating STAT3/SOCS3 expressions in tissue resident macrophages., PMID:38160988

The Promotion of Humoral Immune Responses in Humans via SOCS1-Mediated Th2-Bias Following SARS-CoV-2 Vaccination., PMID:38006062

TNFα counteracts interleukin-10 anti-inflammatory pathway through the NOX2-Lyn-SHP-1 axis in human monocytes., PMID:37757542

Aberrant expression of suppressor of cytokine signaling (SOCS) molecules contributes to the development of allergic diseases., PMID:37641429

The miR-17∼92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation., PMID:37578862

Increased SOCS1 and SOCS3 expression in papillary thyroid carcinoma and its association with prognosis., PMID:37522675

Socs3 expression in myeloid cells modulates the pathogenesis of dextran sulfate sodium (DSS)-induced colitis., PMID:37283760

Gene variants and mRNA expression analysis of SOCS3 and its association with serum IL-4 levels in atopic diseases., PMID:37075578

IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling., PMID:37046042

Identification of antigenic epitopes recognized by tumor infiltrating lymphocytes in high grade serous ovarian cancer by multi-omics profiling of the auto-antigen repertoire., PMID:36943460

Immature natural killer cells promote progression of triple-negative breast cancer., PMID:36888695

Xuanfei Baidu Decoction suppresses complement overactivation and ameliorates IgG immune complex-induced acute lung injury by inhibiting JAK2/STAT3/SOCS3 and NF-κB signaling pathway., PMID:36610119

[Effect of HDAC Inhibitor Chidamide on PD-L1 Expression in Peripheral T-Cell Lymphoma]., PMID:36476897

Etanercept alleviates psoriasis by reducing the Th17/Treg ratio and promoting M2 polarization of macrophages., PMID:36444619

Evaluation of effective factors on IL-10 signaling in B cells in patients with selective IgA deficiency., PMID:36102856

Low SOCS3 expression in CD4+ T cells from pemphigus vulgaris patients enhanced Th1- and Th17-cell differentiation and exacerbated acantholysis via STAT activation., PMID:36030709

Phosphatase control of cytokine-mediated overproduction of galactose-deficient IgA1, the main autoantigen in IgA nephropathy., PMID:35987175

RNA Sequencing Reveals Beneficial Effects of Atorvastatin on Endothelial Cells in Acute Kawasaki Disease., PMID:35861833

Reply: Ex vivo SOCS3 gene responsiveness to alarmins in eosinophils of mepolizumab-treated patients is as yet of unknown biological significance., PMID:35777778

Unraveling the role of Epac1-SOCS3 signaling in the development of neonatal-CRD-induced visceral hypersensitivity in rats., PMID:35702948

STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis., PMID:35469842

IL-17A Mediates Demyelination by Activating A1 Astrocytes via SOCS3 During Angiostrongylus cantonensis Infection., PMID:35296090

STAT3 and IL-6 Contribute to Corticosteroid Resistance in an OVA and Ozone-induced Asthma Model with Neutrophil Infiltration., PMID:34760922

Myeloid lineage contributes to pathological choroidal neovascularization formation via SOCS3., PMID:34688035

Pro-protein convertase subtilisin/kexin type 9 promotes intestinal tumor development by activating Janus kinase 2/signal transducer and activator of transcription 3/SOCS3 signaling in ApcMin/+ mice., PMID:34586888

IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation., PMID:34403503

NR1D1 suppressed the growth of ovarian cancer by abrogating the JAK/STAT3 signaling pathway., PMID:34330232

ShenLian Extract Enhances TGF-β Functions in the Macrophage-SMC Unit and Stabilizes Atherosclerotic Plaques., PMID:34122091

Suppressor of cytokine signalling 3 (SOCS3) expressed in podocytes attenuates glomerulonephritis and suppresses autoantibody production in an imiquimod-induced lupus model., PMID:34016718

Rescue of STAT3 Function in Hyper-IgE Syndrome Using Adenine Base Editing., PMID:33876960

Targeting cancer-associated fibroblast-secreted WNT2 restores dendritic cell-mediated antitumour immunity., PMID:33692094

YY1 promotes SOCS3 expression to inhibit STAT3‑mediated neuroinflammation and neuropathic pain., PMID:33300076

Chronic Toxoplasma gondii Infection Alleviates Experimental Autoimmune Encephalomyelitis by the Immune Regulation Inducing Reduction in IL-17A/Th17 Via Upregulation of SOCS3., PMID:33205383

Farnesoid X receptor activation induces antitumour activity in colorectal cancer by suppressing JAK2/STAT3 signalling via transactivation of SOCS3 gene., PMID:33164339

Fasciola hepatica Extracellular Vesicles isolated from excretory-secretory products using a gravity flow method modulate dendritic cell phenotype and activity., PMID:32898175

Gut Hormone GIP Induces Inflammation and Insulin Resistance in the Hypothalamus., PMID:32603429

Clinical Management and Therapeutic Strategies for the Thyroid-Associated Ophthalmopathy: Current and Future Perspectives., PMID:32567373

COMMD8 changes expression during initial phase of wasp venom immunotherapy., PMID:32559011

IL-15 in the Combination Immunotherapy of Cancer., PMID:32508818

CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b-CD103+ DCs., PMID:32209473

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