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Anti-WASL Antibody (R2T42)

Catalog #:   RHA10503 Specific References (30) DATASHEET
Host species: Mouse
Isotype: IgG2a
Applications: IHC, IP
Accession: O00401
Overview

Catalog No.

RHA10503

Species reactivity

Human, Mouse

Host species

Mouse

Isotype

IgG2a

Clonality

Monoclonal

Tested applications

IHC: 1:100-1:200, IP: 1:100-1:200

Target

N-WASP, WASL, Neural Wiskott-Aldrich syndrome protein

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O00401

Applications

IHC, IP

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R2T42

Data Image
  • Immunohistochemical
    IHC-P analysis of small intestine tissue by WASL antibody (RHA10503). IHC-P was performed using sections of the formalin-fixed paraffin-embedded small intestine tissue;Result: Glandular cells are positively stained at the cytoplasm and nuclei.
  • Immunoprecipitation
    Lane 1: Mouse brain tissue lysate ; Lane 2: WASL immunoprecipitated from mouse brain tissue lysate by RHA10503;Lane 3: The same Lane 2 but use IgG isotype control antibody ;Result: RHA10503 can immunoprecipitate WASL;
References

N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters., PMID:38085658

WASP family proteins regulate the mobility of the B cell receptor during signaling activation., PMID:31974357

VCA nanobodies target N-WASp to reduce invadopodium formation and functioning., PMID:28938008

EtpE Binding to DNase X Induces Ehrlichial Entry via CD147 and hnRNP-K Recruitment, Followed by Mobilization of N-WASP and Actin., PMID:26530384

N-WASP is required for B-cell-mediated autoimmunity in Wiskott-Aldrich syndrome., PMID:26468226

Effect of omega-3 polyunsaturated fatty acids on the cytoskeleton: an open-label intervention study., PMID:25971815

Conditional N-WASP knockout in mouse brain implicates actin cytoskeleton regulation in hydrocephalus pathology., PMID:24462670

N-wasp is essential for the negative regulation of B cell receptor signaling., PMID:24223520

Serine phosphorylation of cortactin is required for maximal host cell invasion by Campylobacter jejuni., PMID:24188565

Recent advances in chronic lymphocytic leukemia., PMID:22842181

The WASp-based actin polymerization machinery is required in somatic support cells for spermatid maturation and release., PMID:21652648

The fadD2 gene is required for efficient Mycobacterium avium invasion of mucosal epithelial cells., PMID:16544254

The NF2 tumor suppressor Merlin and the ERM proteins interact with N-WASP and regulate its actin polymerization function., PMID:15699051

Cellular localization of activated N-WASP using a conformation-sensitive antibody., PMID:15362118

Inducible clustering of membrane-targeted SH3 domains of the adaptor protein Nck triggers localized actin polymerization., PMID:14711409

Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells., PMID:14645152

Actin-based motility of Burkholderia pseudomallei involves the Arp 2/3 complex, but not N-WASP and Ena/VASP proteins., PMID:12780776

Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP., PMID:12769847

Neural Wiskott-Aldrich syndrome protein is recruited to rafts and associates with endophilin A in response to epidermal growth factor., PMID:12477732

Syndapins integrate N-WASP in receptor-mediated endocytosis., PMID:12426380

The F-actin side binding activity of the Arp2/3 complex is essential for actin nucleation and lamellipod extension., PMID:11369208

WIP regulates N-WASP-mediated actin polymerization and filopodium formation., PMID:11331876

N-WASP, WAVE and Mena play different roles in the organization of actin cytoskeleton in lamellipodia., PMID:11282031

Role of the PI3K regulatory subunit in the control of actin organization and cell migration., PMID:11038173

Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex., PMID:10995437

A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization., PMID:10878810

Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein., PMID:9950691

Inhibition of the development of spontaneous autoimmune thyroiditis in the obese strain (OS) chickens by in vivo treatment with anti-CD4 or anti-CD8 antibodies., PMID:9650090

Identification of N-WASP homologs in human and rat brain., PMID:9322739

Prevention of spontaneous autoimmune thyroiditis in the obese strain (OS) chickens by treatment with a monoclonal anti-CD4 antibody., PMID:8767730

Datasheet

Document Download

Anti-WASL Antibody (R2T42).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-WASL Antibody (R2T42) [RHA10503]
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