Please ensure Javascript is enabled for purposes of website accessibility
Home / Products / Research Biosimilar

Research Grade Sintilimab (DHH02207)

Host species:Human
Isotype:IgG4-kappa
Applications:Research Grade Biosimilar
Expression system:Mammalian Cells
Overview

Catalog No.

DHH02207

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG4-kappa

Clonality

Monoclonal

Target

Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279

Concentration

1.57 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q15116

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

IBI-308, CAS: 2072873-06-2

Clone ID

Sintilimab

Data Image
  • Bioactivity
    Detects Human CD279/PDCD1/PD1 in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Sintilimab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Sintilimab: A Promising Anti-Tumor PD-1 Antibody, PMID: 33324564

Sintilimab: First Global Approval, PMID: 30742278

Neoadjuvant PD-1 inhibitor (Sintilimab) in NSCLC, PMID: 32036071

Efficacy and Safety of Sintilimab Plus Pemetrexed and Platinum as First-Line Treatment for Locally Advanced or Metastatic Nonsquamous NSCLC: a Randomized, Double-Blind, Phase 3 Study (Oncology pRogram by InnovENT anti-PD-1-11), PMID: 32781263

Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit, PMID: 31402780

Recent updates on Sintilimab in solid tumor immunotherapy, PMID: 33292551

Safety and activity of sintilimab in patients with relapsed or refractory classical Hodgkin lymphoma (ORIENT-1): a multicentre, single-arm, phase 2 trial, PMID: 30612710

Effectiveness and safety of toripalimab, camrelizumab, and sintilimab in a real-world cohort of hepatitis B virus associated hepatocellular carcinoma patients, PMID: 33241036

Safety and efficacy of sintilimab combined with oxaliplatin/capecitabine as first-line treatment in patients with locally advanced or metastatic gastric/gastroesophageal junction adenocarcinoma in a phase Ib clinical trial, PMID: 32795349

Response to Letter to the Editor: Efficacy and Safety of Sintilimab Plus Pemetrexed and Platinum as First-Line Treatment for Locally Advanced or Metastatic Nonsquamous NSCLC: A Randomized, Double-Blind, Phase 3 Study (ORIENT-11), PMID: 33246599

Efficacy and safety of sintilimab in combination with chemotherapy in previously untreated advanced or metastatic nonsquamous or squamous NSCLC: two cohorts of an open-label, phase 1b study, PMID: 33070260

Another Brick in the Wall: Sintilimab Plus Chemotherapy in Advanced Lung Cancer, PMID: 32981596

Sintilimab-Induced Autoimmune Diabetes in a Patient With the Anti-tumor Effect of Partial Regression, PMID: 32973816

Circulating tumor DNA predicts response in Chinese patients with relapsed or refractory classical hodgkin lymphoma treated with sintilimab, PMID: 32304999

Sintilimab: another effective immune checkpoint inhibitor in classical Hodgkin lymphoma, PMID: 30612711

Antibodies to watch in 2019, PMID: 30516432

Sintilimab as salvage treatment in an HIV patient with relapsed/refractory Hodgkin: a case report, PMID: 32692239

Sintilimab, a PD-1 Inhibitor, Completely Reversed Rarely Refractory Hypofibrinogenemia in a Gastric Cancer Patient: A Case Report and Review of the Literature, PMID: 33194584

Durable Response to Sintilimab and Chidamide in a Patient With Pegaspargase- and Immunotherapy-Resistant NK/T-Cell Lymphoma: Case Report and Literature Review, PMID: 33363038

Unexpected favorable outcome to sintilimab plus bevacizumab in an EGFR-mutated non-small cell lung cancer patient: A case report, PMID: 32656988

Pulmonary fibrosis and cytokine release syndrome after hyperactivation with sintilimab, PMID: 32662522

Sintilimab induced diabetic ketoacidosis in a patient with small cell lung cancer: A case report and literature review, PMID: 34106616

Sintilimab Plus Platinum and Gemcitabine as First-Line Treatment for Advanced or Metastatic Squamous NSCLC: Results From a Randomized, Double-Blind, Phase 3 Trial (ORIENT-12), PMID: 34048947

Complete response to the combination of sintilimab and IBI305 for a patient with HBV-associated hepatocellular carcinoma with multiple lung metastasis, PMID: 32386943

Withdrawn: Effectiveness and safety of toripalimab, camrelizumab and sintilimab in a real-world cohort of hepatitis B virus associated hepatocellular carcinoma patients, PMID: 32627214

Promising response to a PD-1 inhibitor (sintilimab) in non-small cell lung cancer: A case report, PMID: 32481252

Marked elevation of creatine phosphokinase alone caused by sintilimab - beware of hypothyroid myopathy, PMID: 32109851

Immune checkpoint inhibitor-induced myocarditis in lung cancer patients: a case report of sintilimab-induced myocarditis and a review of the literature, PMID: 33545801

Immunotherapy in Hodgkin Lymphoma: Present Status and Future Strategies, PMID: 31362369

The binding epitope of sintilimab on PD-1 revealed by AbMap, PMID: 33637989

Sintilimab plus a bevacizumab biosimilar (IBI305) versus sorafenib in unresectable hepatocellular carcinoma (ORIENT-32): a randomised, open-label, phase 2-3 study, PMID: 34143971

Treatment of advanced intrahepatic cholangiocarcinoma with sintilimab combined with tegafur-gimeracil-oteracil potassium capsules (S-1): a case report, PMID: 32233637

Myositis-myasthenia gravis overlap syndrome complicated with myasthenia crisis and myocarditis associated with anti-programmed cell death-1 (sintilimab) therapy for lung adenocarcinoma, PMID: 32309397

Meta-analysis of immune-related adverse events of immune checkpoint inhibitor therapy in cancer patients, PMID: 32643323

Sintilimab in Treating Advanced Lung Squamous Cell Carcinoma After Fourth-Line Treatment of Anlotinib Resistance, PMID: 34145167

Retraction notice to "30MO ORIENT-3: A randomized, open-label, phase III study of sintilimab versus docetaxel in previously treated advanced/metastatic squamous non-small cell lung cancer (sqNSCLC)": [Annals of Oncology Volume 31, Supplement 7, December 2020, Page S1428], PMID: 33736838

Phase 1b Study of Sintilimab Plus Anlotinib as First-line Therapy in Patients With Advanced NSCLC, PMID: 33524601

Fasciitis induced by sintilimab in a patient with recurrent hepatocellular carcinoma, PMID: 34364744

Complete pathological response with diabetic ketoacidosis to the combination of sintilimab and anlotinib in an unresectable hepatocellular carcinoma patient: a case report, PMID: 34338239

The approval of sintilimab for classical Hodgkin's lymphoma: views and perspectives of anti-PD-1/PD-L1 antibodies in China, PMID: 33928222

Effect of Sintilimab combined with Chemotherapy on Tumor Markers and Immune Function of advanced non-small cell lung cancer, PMID: 34290784

RETRACTED: ORIENT-3: A randomized, open-label, phase III study of sintilimab versus docetaxel in previously treated advanced/metastatic squamous non-small cell lung cancer (sqNSCLC), PMID: 33517977

Case Report: Anlotinib Combined With Sintilimab as Third-Line Treatment in a Metastatic Urothelial Bladder Carcinoma Patient With FGFR3 Mutation, PMID: 34109111

Discovery of New Immune Checkpoints: Family Grows Up, PMID: 32185707

A rapid response of lung squamous cell carcinoma following treatment with sintilimab combined with recombinant humane endostatin injection and nab-paclitaxel in an elderly patient: A case report, PMID: 34397833

Updated Overall Survival Data and Predictive Biomarkers of Sintilimab Plus Pemetrexed and Platinum as First-Line Treatment for Locally Advanced or Metastatic Nonsquamous NSCLC in the Phase 3 ORIENT-11 Study, PMID: 34358724

Sustained remission of multi-line relapsed extranodal NK/T-cell lymphoma, nasal type, following sintilimab and chidamide: A case report, PMID: 33725836

Severe immune-related hyperthermia followed by immune-related pneumonitis with PD-1 inhibitor (sintilimab) in small cell lung cancer: A case report, PMID: 33949137

Pazopanib together with 6-8 cycles of sintilimab followed by single use of pazopanib in the second-line treatment of advanced renal cell carcinoma, PMID: 34159088

A Remarkable and Durable Response to Sintilimab and Anlotinib in the First-Line Treatment of an Anaplastic Thyroid Carcinoma without Targetable Genomic Alterations: A Case Report, PMID: 33907417

Datasheet

Document Download

Research Grade Sintilimab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

Contact Information

Order: order@antibodysystem.com

Mail: support@antibodysystem.com

Distributor list

For research use only. Not for human or drug use.

Need help with your order?

Find out more about placing an order here

Research Grade Sintilimab [DHH02207]
Terms of sale Website terms of use Cookie policy Privacy
Copyright © 2024 AntibodySystem SAS. All Rights Reserved.            All Products are for Research Use Only