Catalog No.
VMD84001
Species reactivity
Mouse
Host species
Rat
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
Il12b, Interleukin-12 subunit beta, IL-12B, CLMF p40, IL-12 subunit p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit
Concentration
1 mg/ml
Endotoxin level
< 1 EU/mg as determined by LAL test.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Applications
ELISA, In vivo Functional Assay
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
C17.8
Immunogenicity of an Intranasal Dual (Core and Surface)-Antigen Vaccine Against Hepatitis B Virus Enhanced by Carboxyl-Vinyl Polymer Excipients., PMID:40432076
Anti-IL-12/23p40 antibodies for induction of remission in Crohn's disease., PMID:40357993
Successful Treatment of Ustekinumab-Associated Lichenoid Drug Eruption with Upadacitinib: A Case Report., PMID:40196725
Self-assembling sequentially administered tumor targeted Split IL-12p35 and p40 subunits to improve the therapeutic index of systemically delivered IL-12 therapy for cancer., PMID:40154091
The influence of genetic factors on the clinical manifestations and response to systemic treatment of plaque psoriasis., PMID:40095058
High-affinity nanobodies targeting IL-12B for the detection of fluorescence resonance energy transfer., PMID:39921134
Characterization for the Similarity Assessment Between the Proposed Biosimilar SB17 and Ustekinumab Reference Product Using State-of-the-Art Analytical Methods., PMID:39821182
Virus Protein-Specific Immune Responses in Selective Depletion of Lymphocyte Populations Using Monoclonal Antibodies in Bolivian Squirrel Monkeys (Saimiri boliviensis boliviensisv)., PMID:39745246
Successful Treatment of Adalimumab-Induced Paradoxical Skin Reactions in Pustulotic Arthro-Osteitis With Guselkumab., PMID:39469389
IL-23 inhibition for chronic inflammatory disease., PMID:39461795
Recent clinical evidence on nutrition, novel pharmacotherapy, and vaccination in inflammatory bowel diseases., PMID:39308999
Interleukin-12p40 deficiency attenuates myocardial ferroptosis in doxorubicin-induced chronic cardiomyopathy by inhibiting Th17 differentiation and interleukin-17A production., PMID:39298642
Correction: Kundu et al. Regression of Triple-Negative Breast Cancer in a Patient-Derived Xenograft Mouse Model by Monoclonal Antibodies against IL-12 p40 Monomer. Cells 2022, 11, 259., PMID:39120339
Anti-IL12p40 autoantibodies in a teenage girl with multiple recurrent abscesses., PMID:39098705
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial., PMID:39079992
Interleukin-23 p19 and Interleukin-12 p40, Head-to-Head, against Gut Inflammation., PMID:39018537
Differential detection of chicken heterodimeric cytokines, interleukin 12 and 23 using their subunit-specific mouse monoclonal antibodies., PMID:38848631
Physiologically-based pharmacokinetic modeling to predict the exposure and provide dosage regimens of Ustekinumab in pediatric patients with inflammatory bowel disease., PMID:38797440
Biologics for Psoriasis., PMID:38796266
Insights into Therapeutic Response Prediction for Ustekinumab in Ulcerative Colitis Using an Ensemble Bioinformatics Approach., PMID:38791570
IL-12p40 deletion reduces M1 macrophage polarization and alleviates cardiac remodeling via regulating Th17 cells differentiation, but not γδT 17 cells, in TAC mice., PMID:38677538
The first case report of de novo Crohn's disease after heart transplantation successfully treated with ustekinumab., PMID:38646076
Ustekinumab in the Treatment of Inflammatory Bowel Diseases: Evolving Paradigms., PMID:38592377
Non-Infectious Pneumonitis and Acute Respiratory Distress Syndrome in a Patient on Ustekinumab Treatment: Case Report and Literature Review., PMID:38541718
Anti-Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency., PMID:38507753
Formation and clinical effects of anti-drug antibodies against biologics in psoriasis treatment: An analysis of current evidence., PMID:38499168
A bibliometric and visual analysis of the use of ustekinumab in Crohn's disease using CiteSpace., PMID:38269276
A novel nomogram for predicting endoscopic remission in refractory Crohn's disease with ustekinumab administration., PMID:38236159
The Role of IL-23 Inhibitors in Crohn's Disease., PMID:38202231
p53 suppresses MHC class II presentation by intestinal epithelium to protect against radiation-induced gastrointestinal syndrome., PMID:38167344
Real-World Data on Short-Term and Long-Term Treatment Results of Ustekinumab in Patients with Steroid-Resistant/Dependent Ulcerative Colitis., PMID:38115909
The Anti-Inflammatory Effects of Adipose Tissue Mesenchymal Stem Cell Exosomes in a Mouse Model of Inflammatory Bowel Disease., PMID:38069197
Immune mediators as predictive biomarkers for anti-PD-1 antibody therapy in urothelial carcinoma., PMID:38026978
Role of ustekinumab in treatment of ulcerative colitis: a narrative review., PMID:38018475
Signal conversion as tumor micro environment (TME) specifically activated cytokine., PMID:37890200
Protective efficacy and correlates of immunity of immunodominant recombinant Babesia microti antigens., PMID:37728332
Generation and Characterization of Mirikizumab, a Humanized Monoclonal Antibody Targeting the p19 Subunit of IL-23., PMID:37714687
Baseline Peripheral Blood Mononuclear Cell Transcriptomics Before Ustekinumab Treatment Is Linked With Crohn's Disease Clinical Response at 1 Year., PMID:37655708
Application of phosphorylcholine derivative as mucosal adjuvant enhancing mucosal immune responses in the upper respiratory tract., PMID:37532644
Detection of IL12/23p40 via PET Visualizes Inflammatory Bowel Disease., PMID:37474270
Differential expression of IFN-α, IL-12 and BAFF on renal immune cells and its relevance to disease activity and treatment responsiveness in patients with proliferative lupus nephritis., PMID:37460249
Infliximab-induced psoriasis in an ulcerative colitis patient successfully treated with guselkumab., PMID:37314119
Report of two sisters with Netherton syndrome successfully treated with dupilumab and review of the literature., PMID:37200480
Hypersensitivity Reaction to Ustekinumab in Pediatric and Young Adult Inflammatory Bowel Disease Patients: A Case Series., PMID:37168900
Higher Ustekinumab Levels in Maintenance Therapy are Associated with Greater Mucosal Healing and Mucosal Response in Crohn's Disease: An Experience of 2 IBD Centers., PMID:37158577
Guselkumab More Effectively Neutralizes Psoriasis-Associated Histologic, Transcriptomic, and Clinical Measures than Ustekinumab., PMID:37071038
IL-12 and IL-23 pathway inhibition in inflammatory bowel disease., PMID:37069321
A critical review of ustekinumab for the treatment of active ulcerative colitis in adults., PMID:36949608
The protective effect of IL-12/23 neutralizing antibody in sarcopenia associated with dextran sulfate sodium-induced experimental colitis., PMID:36872597
Sustaining the T-cell activity in xenografted psoriasis skin., PMID:36649237
For research use only. Not for human or drug use.
