Catalog No.
AHE70701
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Thr27-Pro184
Predicted molecular weight
19 kDa
Nature
Recombinant
Endotoxin level
< 0.01 EU/µg as determined by LAL test.
Purity
>90% as determined by SDS-PAGE.
Accession
P49771
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a 0.2 μm filtered solution in 20 mM Tris, 150 mM NaCl, pH 8.0.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SL cytokine, FLT3LG, Fms-related tyrosine kinase 3 ligand, Flt3 ligand, Flt3L
FLT3LG modulates the infiltration of immune cells and enhances the efficacy of anti-PD-1 therapy in lung adenocarcinoma., PMID:40329265
Enhancing antitumor immunity through chemotherapeutic-derived lipid nanoparticle-induced immunogenic cell death and CD40L/Flt3L mRNA-mediated dendritic cell activation., PMID:40185331
Dectin-1-Dependent Activation of Flt3 Ligand-Induced Dendritic Cells by the Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes) Fruiting Body., PMID:40100228
Effect of FLT3 ligand on the gene expression of TIM-3, HIF1-α, and TNF-α in an acute myeloid leukemia cell line., PMID:40085277
In vitro differentiation of common lymphoid progenitor cells into B cell using stromal cell free culture system., PMID:40038600
A single point mutation on FLT3L-Fc protein increases the risk of immunogenicity., PMID:40018031
Microwave Ablation Combined with Flt3L Provokes Tumor-Specific Memory CD8+ T Cells-Mediated Antitumor Immunity in Response to PD-1 Blockade., PMID:39629989
Pre-pregnancy obesity is associated with an altered maternal metabolome and reduced Flt3L expression in preterm birth., PMID:39627409
Flt3L enhances clonal diversification and selective expansion of intratumoral CD8+ T cells while differentiating into effector-like cells., PMID:39616612
Human dendritic cell differentiation in hematopoietic stem cell-transplanted NOG hFLT3L Tg/mFlt3 KO humanized mice., PMID:39536946
Electroporation-mediated novel albumin-fused Flt3L DNA delivery promotes cDC1-associated anticancer immunity., PMID:39472678
Combined Autophagy Inhibition and Dendritic Cell Recruitment Induces Antitumor Immunity and Enhances Immune Checkpoint Blockade Sensitivity in Pancreatic Cancer., PMID:39288081
Flt3 ligand augments immune responses to soluble PD1-based DNA vaccine via expansion of type 1 conventional DCs., PMID:39168022
The causal relationship between immune cells mediating FIT3L, CCL4, OSM, and skin-derived deteriorated tumors., PMID:38953214
FLT3+ DC inhibits immune rejection via interaction with Treg in liver transplantation., PMID:38889505
Flt3 agonist enhances immunogenicity of arenavirus vector-based simian immunodeficiency virus vaccine in macaques., PMID:38829139
FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice., PMID:38701783
Role of Flt3l and Rps15 in ketamine anesthesia., PMID:38428846
FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors., PMID:38287325
Identification of dendritic cell precursor from the CD11c+ cells expressing high levels of MHC class II molecules in the culture of bone marrow with FLT3 ligand., PMID:38094300
Antigen-loaded Monocyte Administration and Flt3 Ligand Augment the Antitumor Efficacy of Immune Checkpoint Blockade in a Murine Melanoma Model., PMID:37737688
Enrichment of Large Numbers of Splenic Mouse Dendritic Cells After Injection of Flt3L-Producing Tumor Cells., PMID:36905517
Early-life hyperoxia-induced Flt3L drives neonatal lung dendritic cell expansion and proinflammatory responses., PMID:36845082
Modulation of Radiation Biomarkers in a Randomized Phase II Study of 131I-MIBG With or Without Radiation Sensitizers for Relapsed or Refractory Neuroblastoma., PMID:36526235
FLT3LG and IFITM3P6 consolidate T cell activity in the bone marrow microenvironment and are prognostic factors in acute myelocytic leukemia., PMID:36081495
Class I PI3K regulatory subunits control differentiation of dendritic cell subsets and regulate Flt3L mediated signal transduction., PMID:35853935
Single-cell RNA sequencing distinguishes dendritic cell subsets in the rat, allowing advanced characterization of the effects of FMS-like tyrosine kinase 3 ligand., PMID:35285040
Neoadjuvant In Situ Immunomodulation Enhances Systemic Antitumor Immunity against Highly Metastatic Tumors., PMID:34666993
FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC., PMID:34518311
Dendritic cells play no significant role in the laser-induced choroidal neovascularization model., PMID:34446787
Multimodal Intralesional Therapy for Reshaping the Myeloid Compartment of Tumors Resistant to Anti-PD-L1 Therapy via IRF8 Expression., PMID:34362833
A protocol for qualitative and quantitative measurement of endosomal processing using hot spot analysis., PMID:34278334
Cellular Basis for the Enhanced Efficacy of the Fms-Like Tyrosine Kinase 3 Ligand (FL) Adjuvanted VCG-Based Chlamydia abortus Vaccine., PMID:34249004
Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma., PMID:34083417
DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells., PMID:33980589
Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development., PMID:33862015
Engineering and crystal structure of a monomeric FLT3 ligand variant., PMID:33830077
Respiratory FimA-Specific Secretory IgA Antibodies Upregulated by DC-Targeting Nasal Double DNA Adjuvant Are Essential for Elimination of Porphyromonas gingivalis., PMID:33717178
Expression of a recombinant FLT3 ligand and its emtansine conjugate as a therapeutic candidate against acute myeloid leukemia cells with FLT3 expression., PMID:33691697
Single-cell analyses reveal the clonal and molecular aetiology of Flt3L-induced emergency dendritic cell development., PMID:33649477
The murine DCs transfected with DNA-plasmid encoding CCR9 demonstrate the increased migration to CCL25 and thymic cells in vitro and to the thymus in vivo., PMID:33647585
Reduced circulating dendritic cells in acute Plasmodium knowlesi and Plasmodium falciparum malaria despite elevated plasma Flt3 ligand levels., PMID:33593383
Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4., PMID:33443099
A new cytokine-based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia., PMID:33369136
Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets., PMID:35121932
Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs., PMID:33086061
FLT3 ligand in acute myeloid leukemia: a simple test with deep implications., PMID:33078658
FLT3 Ligand Is Dispensable for the Final Stage of Type 1 Conventional Dendritic Cell Differentiation., PMID:32887750
A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells., PMID:32848036
TNFα Rescues Dendritic Cell Development in Hematopoietic Stem and Progenitor Cells Lacking C/EBPα., PMID:32429067
For research use only. Not for human or drug use.
