Catalog No.
AHE26002
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ser22-Gly353
Predicted molecular weight
37.3 kDa
Nature
Recombinant
Endotoxin level
< 0.01 EU/µg as determined by LAL test.
Purity
>90% as determined by SDS-PAGE.
Accession
P40225
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a 0.2 μm filtered solution in 20 mM Tris, 150 mM NaCl, pH 8.0.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Myeloproliferative leukemia virus oncogene ligand, C-mpl ligand, Thrombopoietin, THPO, Megakaryocyte colony-stimulating factor, Megakaryocyte growth and development factor, ML, MGDF
THPO promoter mutation: a familial study on congenital amegakaryocytic thrombocytopenia., PMID:40386912
[Thrombopoietin-mediated regulation of hematopoietic stem cells]., PMID:39358285
Paclitaxel improves thrombopoiesis in the absence of thrombopoietin receptor (Mpl)., PMID:39307245
Prognostic implications of STK11 with different mutation status and its relationship with tumor-infiltrating immune cells in non-small cell lung cancer., PMID:38736875
Relative impact of THPO mutation causing hereditary thrombocythemia., PMID:38548144
Construction of an immune-related risk score signature for gastric cancer based on multi-omics data., PMID:38228846
Role of platelet count in a murine stasis model of deep vein thrombosis., PMID:38099327
Hereditary thrombocythemia due to splicing donor site mutation of THPO in a Japanese family., PMID:37962621
Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis., PMID:37633268
Genomic Variation Affecting MPV and PLT Count in Association with Development of Ischemic Stroke and Its Subtypes., PMID:37453995
Genomic and computational analysis of four novel variants of MPL gene in Congenital Amegakaryocytic Thrombocytopenia., PMID:37438490
Whole exome sequencing and rare variant association study to identify genetic modifiers, KLF1 mutations, and a novel double mutation in Thai patients with hemoglobin E/beta-thalassemia., PMID:36939018
Identification of putative noncanonical driver mutations in patients with essential thrombocythemia., PMID:36811253
Thrombopoietin participates in platelet activation in COVID-19 patients., PMID:36242922
Defective binding of ETS1 and STAT4 due to a mutation in the promoter region of THPO as a novel mechanism of congenital amegakaryocytic thrombocytopenia., PMID:36226497
Inhibition of Canonical Wnt Signaling Promotes Ex Vivo Maintenance and Proliferation of Hematopoietic Stem Cells in Zebrafish., PMID:35759948
Generation of a thrombopoietin-deficient thrombocytopenia model in zebrafish., PMID:35622056
Periodontal Disease Augments Cardiovascular Disease Risk Biomarkers in Rheumatoid Arthritis., PMID:35327515
Multiplex Protein Biomarker Profiling in Patients with Familial Hypercholesterolemia., PMID:34680994
Thrombopoietin from hepatocytes promotes hematopoietic stem cell regeneration after myeloablation., PMID:34463253
Identification of novel candidate genes for age at first calving in Nellore cows using a SNP chip specifically developed for Bos taurus indicus cattle., PMID:34392169
[Thrombopoietin regulates mitochondria homeostasis for hematopoietic stem cell maintenance]., PMID:34248130
Thrombopoietin Contributes to Enhanced Platelet Activation in Patients with Type 1 Diabetes Mellitus., PMID:34210000
Clinical course of myeloproliferative leukaemia virus oncogene (MPL) mutation-associated familial thrombocytosis: a review of 64 paediatric and adult patients., PMID:34131895
Thrombocytosis in children and adolescents-classification, diagnostic approach, and clinical management., PMID:33712866
Cooperative Role of Thrombopoietin and Vascular Endothelial Growth Factor-A in the Progression of Liver Cirrhosis to Hepatocellular Carcinoma., PMID:33673041
Prolonged maintenance of hematopoietic stem cells that escape from thrombopoietin deprivation., PMID:33657206
[Efficacy of thrombopoietin in bone marrow failure]., PMID:33162439
Augmentation of NK Cell Proliferation and Anti-tumor Immunity by Transgenic Expression of Receptors for EPO or TPO., PMID:33010232
Thrombopoietin is associated with a prognosis of gastric adenocarcinoma., PMID:32638965
Thrombopoietin maintains cell numbers of hematopoietic stem and progenitor cells with megakaryopoietic potential., PMID:32527954
Liver gene regulation of hemostasis-related factors is altered by experimental snake envenomation in mice., PMID:32479494
Visual High-Throughput Screening for Developing a Fatty Acid Amide Hydrolase Natural Inhibitor Based on an Enzyme-Activated Fluorescent Probe., PMID:32456414
A novel thrombopoietin (THPO) mutation altering mRNA splicing in a case of familial thrombocytosis., PMID:32430933
Signaling properties of murine MPL and MPL mutants after stimulation with thrombopoietin and romiplostim., PMID:32417303
A Pilot Study on the Effect of Anti-Thrombopoietin Antibody on Platelet Count in Patients with Type 2 Diabetes., PMID:32260359
Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer., PMID:32235817
Monoallelic loss-of-function THPO variants cause heritable thrombocytopenia., PMID:32150607
Thrombocythemia 1 With THPO Variant (c.13+1G>A) Diagnosed Using Targeted Exome Sequencing: First Case in Korea., PMID:32067437
HB-EGF Improves the Hair Regenerative Potential of Adipose-Derived Stem Cells via ROS Generation and Hck Phosphorylation., PMID:31878047
Diagnostic workflow for hereditary erythrocytosis and thrombocytosis., PMID:31808840
Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice., PMID:31648335
Multifaceted roles of thrombopoietin in hematopoietic stem cell regulation., PMID:31292976
Hematopoietic growth factors: the scenario in zebrafish., PMID:30764671
Endothelial protein C receptor supports hematopoietic stem cell engraftment and expansion in Mpl-deficient mice., PMID:30683655
Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis., PMID:30593567
Effects of Cold Atmospheric Plasma on the Expression of Chemokines, Growth Factors, TNF Superfamily Members, Interleukins, and Cytokines in Human Osteosarcoma Cells., PMID:30591452
Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation., PMID:30428347
A network map of thrombopoietin signaling., PMID:30039510
Inherited THPO mutation, with morphology resembling chronic myeloid leukaemia., PMID:30010186
For research use only. Not for human or drug use.
