Catalog No.
AHB08601
Expression system
Mammalian cells
Species
Homo sapiens (Human)
Protein length
Ser21-Ser1725
Predicted molecular weight
191 kDa
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
O75096
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 2% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Low-density lipoprotein receptor-related protein 4, MEGF7, LRP10, LRP4, LRP-4, KIAA0816, Multiple epidermal growth factor-like domains 7
Potential therapeutic targets for deep vein thrombosis: A proteome-wide Mendelian randomization study., PMID:40462713
Periplocin targets LRP4 to regulate metabolic homeostasis and anti-inflammation for the treatment of IVDD., PMID:40440911
Alterations in gene expression associated with invasion of RAS-mutant thyroid tumors and their potential diagnostic and therapeutic utility., PMID:40440326
Myasthenia gravis with double-seropositive acetylcholine receptor and low-density lipoprotein receptor-related protein 4 antibodies combined with muscle atrophy: a case report and literature review., PMID:40356916
Agrin/Dok-7-induced JPH2 phosphorylation in muscle cells is involved in AChR clustering., PMID:40290048
Rozanolixizumab for Myasthenia Gravis: a breakthrough treatment and future prospects., PMID:40277145
Efgartigimod improves non-AChR generalized Myasthenia Gravis: a real world experience., PMID:40128464
A Case of Myasthenia Gravis: A Paraneoplastic Syndrome or an Immune-Related Disorder?, PMID:40062097
Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance., PMID:40044687
LRP4 and Agrin Are Modulated by Cartilage Degeneration and Involved in β-Catenin Signaling in Human Articular Chondrocytes., PMID:39940775
(2R, 6R)-hydroxynorketamine alleviates postictal depression induced by pilocarpine through modulating LRP4 expression in hippocampal astrocytes., PMID:39923723
Identifying rare variants in genes related to bone phenotypes in a cohort of postmenopausal women., PMID:39915337
MuSK Regulates Neuromuscular Junction Nav1.4 Localization and Excitability., PMID:39880682
A bioinformatic approach to characterize the vitellogenin receptor and the low density lipoprotein receptor superfamily in the newt Cynops orientalis., PMID:39870874
Safety and efficacy of satralizumab in patients with generalised myasthenia gravis (LUMINESCE): a randomised, double-blind, multicentre, placebo-controlled phase 3 trial., PMID:39862880
Safety and efficacy of nipocalimab in adults with generalised myasthenia gravis (Vivacity-MG3): a phase 3, randomised, double-blind, placebo-controlled study., PMID:39862879
Oleandrin inhibits osteoclast differentiation by targeting the LRP4/MAPK/NF-κB signalling pathway to treat osteoporosis., PMID:39823799
LRP4 mutations promote tumor progression and resistance to anti-PD-1 therapy in recurrent hepatocellular carcinoma., PMID:39723987
A clinical perspective on muscle specific kinase antibody positive myasthenia gravis., PMID:39703505
Regulation of miR-206 in denervated and dystrophic muscles, and its effect on acetylcholine receptor clustering., PMID:39575567
Heavy duty., PMID:39521071
Acute high-intensity muscle contraction moderates AChR gene expression independent of rapamycin-sensitive mTORC1 pathway in rat skeletal muscle., PMID:39501426
Mapping the sclerostin-LRP4 binding interface identifies critical interaction hotspots in loops 1 and 3 of sclerostin., PMID:39443289
Identification of potential biomarkers of papillary thyroid carcinoma., PMID:39400774
Lipoprotein Receptor-Related Protein 4 Antibody Positivity in the Youngest Patient in the Caucasus Region: A Case Report., PMID:39385918
The changing landscape of autoantibody testing in myasthenia gravis in the setting of novel drug treatments., PMID:39357636
Agonist antibody to MuSK protects mice from MuSK myasthenia gravis., PMID:39288173
Myasthenia gravis., PMID:39174248
A class of chemical compounds enhances clustering of muscle nicotinic acetylcholine receptor in cultured myogenic cells., PMID:39024975
A conserved RNA switch for acetylcholine receptor clustering at neuromuscular junctions in chordates., PMID:39005407
Therapeutic challenges and unmet needs in the management of myasthenia gravis: an Italian expert opinion., PMID:38967883
Heterogeneous Presentations and Serologies in Myasthenia Gravis Patients Presenting with Dysphagia., PMID:38949061
[Effects of different exercise modes on neuromuscular junction and metabolism of skeletal muscle-related proteins in aging rats]., PMID:38939932
Unusual Presentation of Double-seronegative Myasthenia Gravis with Positive Anti-LRP4 Antibody: Diagnostic Utility of a Videofluoroscopic Swallowing Study., PMID:38897960
Identification of pleiotropic and specific therapeutic targets for cardio-cerebral diseases: A large-scale proteome-wide mendelian randomization and colocalization study., PMID:38820305
Effects of physical exercise on neuromuscular junction degeneration during ageing: A systematic review., PMID:38817243
Treating myasthenia gravis beyond the eye clinic., PMID:38789789
Agrin-Lrp4 pathway in hippocampal astrocytes restrains development of temporal lobe epilepsy through adenosine signaling., PMID:38783336
Neuronal LRP4 directs the development, maturation and cytoskeletal organization of Drosophila peripheral synapses., PMID:38738619
The MuSK agonist antibody protects the neuromuscular junction and extends the lifespan in C9orf72-ALS mice., PMID:38734896
Building, Breaking, and Repairing Neuromuscular Synapses., PMID:38697654
Suppression of AGRN enhances CD8+ T cell recruitment and inhibits breast cancer progression., PMID:38568853
Functional Signature of LRP4 Antibodies in Myasthenia Gravis., PMID:38507656
Myasthenia gravis-Pathophysiology, diagnosis, and treatment., PMID:38494283
Triple-seronegative myasthenia gravis: clinical and epidemiological characteristics., PMID:38316426
Antibody Response to HERV-K and HERV-W Envelope Epitopes in Patients with Myasthenia Gravis., PMID:38203616
GDF-10 Induces an Inhibitory Effect on Epithelial-Mesenchymal Transition of Laryngeal Cancer via LPR4., PMID:38163971
LRP4 site-specific variants in the third β-propeller domain causes congenital myasthenic syndrome type 17., PMID:38101565
LRP4-related signalling pathways and their regulatory role in neurological diseases., PMID:38065285
An Additional Lrp4 High Bone Mass Mutation Mitigates the Sost-Knockout Phenotype in Mice by Increasing Bone Remodeling., PMID:38051321
For research use only. Not for human or drug use.
