Catalog No.
YHA91102
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser496
Predicted molecular weight
80.55 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60443
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ICERE-1, ICERE1, GSDME-CT, GSDME-NT, DFNA5, Inversely correlated with estrogen receptor expression 1, Gasdermin-E, GSDME, Non-syndromic hearing impairment protein 5
Pyroptosis Mediated by ROS/Caspase-3/GSDME Pathway in Aspergillus fumigatus-Induced Fungal Keratitis., PMID:40525924
Inhibition of Caspase-3/GSDME Pathway-Mediated Pyroptosis of Renal Tubular Epithelial Cells by Dagliflozin in the Pathogenesis of Diabetic Kidney Disease and Study of Its Mechanism., PMID:40524871
Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis., PMID:40523886
GSDMD and GSDME exhibit distinct roles in enteric coronavirus PDCoV-induced pyroptosis and inflammatory responses., PMID:40503916
Dipeptidyl Peptidase 9 in Human Leukocytes: Novel Inhibitors Induce Caspase-1- and Gasdermin-Dependent Cell Death., PMID:40498275
A dual inhibitor of TrxR1 and XIAP induces pyroptosis in melanoma., PMID:40486906
Gasdermin E deficiency limits inflammation and lung damage during influenza virus infection., PMID:40481027
Venetoclax synergizes with Wnt/β-catenin inhibitor C-82 in acute myeloid leukemia by increasing the degradation of Mcl-1 protein., PMID:40442688
A new type of Caspase-1 upon recognizing bacteria inhibits GSDME-dependent histone modification and NF-κB signaling., PMID:40442231
Tailored "Three-stage booster" nano-extinguisher for synergistic treatment of severe acute pancreatitis by rectifying mitochondrial dysfunction and inhibiting pancreatic autodigestion., PMID:40436230
LncRNA16 inhibits pyroptosis and promotes platinum resistance in non-small cell lung cancer by sponging miRNA1827 to regulate MBD3/GSDME expression., PMID:40413520
Taletrectinib promotes pyroptosis in colorectal carcinoma via SRC/AKT/mTOR axis inhibition., PMID:40410374
ANG-Modified Liposomes Coloaded With α-Melittin and Resveratrol Induce Apoptosis and Pyroptosis in Glioblastoma Cells by Impeding Wnt/β-Catenin Signaling., PMID:40400263
mTOR blockade mitigates chemotherapy drug-induced intestinal toxicity via inhibition of pyroptosis., PMID:40398827
Gasdermin E links tumor cell-intrinsic nucleic acid signaling to proinflammatory cell death for successful checkpoint inhibitor cancer immunotherapy., PMID:40366863
Sonodynamic Therapy Induces Pyroptosis and Recruits CAR-NK Cells to Enhance the Treatment of Oral Squamous Cell Carcinoma., PMID:40338058
Mechanistic insights into elevated caspase-8 expression driving caspase-3 activation and Gasdermin E-dependent pyroptosis in Alzheimer's disease., PMID:40334809
NRXN3 regulates pyroptosis in intrahepatic cholangiocarcinoma via mediating the phospho-dependent ubiquitination and degradation of caspase-3., PMID:40324630
An optimized integrin α6-targeted peptide capable of delivering toxins for melanoma treatment., PMID:40307853
Gut-vascular barrier mediated Tripterygium wilfordii-induced liver injury: the synergism between triptolide and celastrol via intestinal FXR-ET-1 pathway., PMID:40306497
Knockdown of PAK1IP1 can Induce Pyroptosis to Inhibit the Progression of Hepatocellular Carcinoma., PMID:40302327
Gasdermin E as a potential target and biomarker for CRISPR-Cas9-based cancer therapy., PMID:40300704
Caerin 1.1 and 1.9 peptides induce acute caspase 3/GSDME-mediated pyroptosis in epithelial cancer cells., PMID:40251208
Ocifisertib alleviates the gasdermin D-independent pyroptosis of nucleus pulposus cells by targeting GSDME., PMID:40247083
Danshensu Attenuates Palmitic Acid-Induced Activation of Hepatic Stellate Cells by Regulating Pyroptosis., PMID:40225863
Teleost GSDMEc regulates GSDMEa-mediated pyroptosis., PMID:40210150
Kaempferol inhibits cardiomyocyte pyroptosis via promoting O-GlcNAcylation of GSDME and improved acute myocardial infarction., PMID:40200275
Arsenic exposure provoked prostatic PANoptosis by inducing mitochondrial dysfunction in mice and WPMY-1 cells., PMID:40185034
Acevaltrate overcomes myeloma resistance to bortezomib via pyroptosis by promoting BAX translocalization to mitochondria., PMID:40180268
PRDM16 suppresses pyroptosis to attenuate the progression of AKI caused by rhabdomyolysis via upregulation of USP10., PMID:40175611
In Situ Delivery of Gasdermin E mRNA Promotes Antitumor Immunity via Creatine-Elicited Type I Interferon Signaling in Monocytes., PMID:40168141
Inhibition of PINK1 senses ROS signaling to facilitate neuroblastoma cell pyroptosis., PMID:40160153
LXR agonists induces GSDME-mediated pyroptosis in tumors through alters the integrity of the MOM to activates Caspase-4/APAF-1 pyroptosome., PMID:40154703
5-FU@HFn combined with decitabine induces pyroptosis and enhances antitumor immunotherapy for chronic myeloid leukemia., PMID:40148810
Dietary AiiO-AIO6 mitigated Aeromonas hydrophila-induced intestinal inflammation in juvenile grass carp (Ctenopharyngodon idella) involving in NF-κB signaling and pyroptosis., PMID:40139288
Fucoxanthin from Laminaria japonica Targeting PANoptosis and Ferroptosis Pathways: Insights into Its Therapeutic Potential Against Ovarian Cancer., PMID:40137309
LL37 complexed to double-stranded RNA induces RIG-I-like receptor signalling and Gasdermin E activation facilitating IL-36γ release from keratinocytes., PMID:40121229
Streptococcus anginosus promotes gastric cancer progression via GSDME-mediated pyroptosis pathway: Molecular mechanisms of action of GSDME, cleaved caspase-3, and NLRP3 proteins., PMID:40118413
Combining photodynamic therapy and ATM inhibition using modified bovine serum albumin: A co-delivery nano platform for eliciting pyroptosis and apoptosis to fuel TNBC therapy., PMID:40112963
Caspase-8 activation regulates enterovirus D68 infection-induced inflammatory response and cell death., PMID:40078725
SNS‑032 combined with decitabine induces caspase‑3/gasdermin E‑dependent pyroptosis in breast cancer cells., PMID:40070781
Ellagic Acid Ameliorates Ovarian Cancer via Modification of Pyroptosis and Inflammation., PMID:40052883
Neuropilin-1-target self-assembled peptide nanoparticles contribute to tumor treatment by inducing pyroptosis., PMID:40050758
Methionine metabolite spermidine inhibits tumor pyroptosis by enhancing MYO6-mediated endocytosis., PMID:40038267
Oxypeucedanin alleviates cisplatin-induced intestinal toxicity through impairing caspase-3/gasdermin E signaling., PMID:40024724
Structurally diverse tetrahydroxanthone analogues from Paraconiothyrium sp. AC31 with pyroptosis induction through targeted inhibition of PARP1 in hepatocellular carcinoma cells., PMID:40024197
Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer., PMID:40010767
Development of attenuated Orf virus as a safe oncolytic viral vector for nasopharyngeal carcinoma treatment., PMID:40001231
Procyanidin B2 mitigates methotrexate-induced hepatic pyroptosis by suppressing TLR4/NF-κB and caspase-3/GSDME pathways., PMID:39988050
For research use only. Not for human or drug use.
