Catalog No.
YHK57402
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ala508
Predicted molecular weight
83.69 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BYG8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Melanoma-derived leucine zipper-containing extranuclear factor, GSDMC, GSDMC-CT, Gasdermin-C, GSDMC-NT, MLZE
Caspase-6/Gasdermin C-Mediated Tumor Cell Pyroptosis Promotes Colorectal Cancer Progression Through CXCL2-Dependent Recruitment of Myeloid-Derived Suppressor Cells., PMID:40213993
Chemo-sensitive and chemo-resistant ovarian cancer cells show differences in cellular processes leading to pyroptotic cell death., PMID:40112594
Comprehensive analyses reveal the promising value of gasdermins as prognostic biomarkers and immunotherapeutic targets in head and neck squamous cell carcinoma., PMID:39807507
Diagnostic and prognostic value of the gasdermins in gastric cancer., PMID:39607202
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair., PMID:39500322
Egg White Diet Induces Severe Allergic Enteritis in an Animal Model Driven by Caspase-3 and Gasdermin C-Mediated Mucosal Alarmin Secretion., PMID:39420749
Pterostilbene Induces Pyroptosis in Breast Cancer Cells through Pyruvate Kinase 2/Caspase-8/Gasdermin C Signaling Pathway., PMID:39408842
Seneca Valley virus circumvents Gasdermin A-mediated inflammation by targeting the pore-formation domain for cleavage., PMID:39207099
Pyroptosis-related gene GSDMC indicates poor prognosis and promotes tumor progression by activating the AKT/mTOR pathway in lung squamous cell carcinoma., PMID:39136610
ELANE is a promising prognostic biomarker that mediates pyroptosis in gastric cancer., PMID:39130462
Intraepithelial mast cells drive gasdermin C-mediated type 2 immunity., PMID:38614091
Assessment the value of Pyroptosis-Associated Gasdermin family genes in hepatocellular carcinoma: A Multi-Omics Comprehensive Analysis., PMID:38434972
To die or not to die: Gasdermins in intestinal health and disease., PMID:38232665
Pyroptosis: a double-edged sword in lung cancer and other respiratory diseases., PMID:38225586
System analysis based on the pyroptosis-related genes identifes GSDMD as a novel therapy target for skin cutaneous melanoma., PMID:37950289
The Pyroptosis-Related Signature Composed of GSDMC Predicts Prognosis and Contributes to Growth and Metastasis of Hepatocellular Carcinoma., PMID:37919059
Sodium Citrate Nanoparticles Induce Dual-Path Pyroptosis for Enhanced Antitumor Immunotherapy through Synergistic Ion Overload and Metabolic Disturbance., PMID:37903236
Gasdermin C sensitizes tumor cells to PARP inhibitor therapy in cancer models., PMID:37883181
High pyroptosis activity in pancreatic adenocarcinoma: poor prognosis and oxaliplatin resistance., PMID:37848674
METTL14-upregulated miR-6858 triggers cell apoptosis in keratinocytes of oral lichen planus through decreasing GSDMC., PMID:37741915
The role of caspase-8 in inflammatory signalling and pyroptotic cell death., PMID:37625331
Role of GSDM family members in airway epithelial cells of lung diseases: a systematic and comprehensive transcriptomic analysis., PMID:37462807
HPV18 E6 inhibits α-ketoglutarate-induced pyroptosis of esophageal squamous cell carcinoma cells via the P53/MDH1/ROS/GSDMC pathway., PMID:37402485
Pyroptosis-induced inflammation and tissue damage., PMID:37352727
The Pyroptotic and Nonpyroptotic Roles of Gasdermins in Modulating Cancer Progression and Their Perspectives on Cancer Therapeutics., PMID:37258998
The influence of pyroptosis-related genes on the development of chronic obstructive pulmonary disease., PMID:37194062
Role of Gasdermin E in the Biogenesis of Apoptotic Cell-Derived Exosomes., PMID:37163338
Detection of Gasdermin C-Mediated Cancer Cell Pyroptosis., PMID:37074647
Pyroptosis, inflammasome, and gasdermins in tumor immunity., PMID:36632024
Prognostic value and immune infiltration of the gasdermin family in lung adenocarcinoma., PMID:36505798
System analysis based on the pyroptosis-related genes identifies GSDMC as a novel therapy target for pancreatic adenocarcinoma., PMID:36199146
Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer., PMID:36175965
LINC00511/hsa-miR-573 axis-mediated high expression of Gasdermin C associates with dismal prognosis and tumor immune infiltration of breast cancer., PMID:36042287
Genetic and Transcriptional Analysis of 8q24.21 Cluster in Gastric Cancer., PMID:36039443
A systematic pan-cancer analysis of the gasdermin (GSDM) family of genes and their correlation with prognosis, the tumor microenvironment, and drug sensitivity., PMID:36003332
N6-adenomethylation of GsdmC is essential for Lgr5+ stem cell survival to maintain normal colonic epithelial morphogenesis., PMID:35917813
Pyroptosis in inflammation-related respiratory disease., PMID:35819638
Development of a Prognostic Model Based on Pyroptosis-Related Genes in Pancreatic Adenocarcinoma., PMID:35677632
A novel pyroptosis risk model composed of NLRP6 effectively predicts the prognosis of hepatocellular carcinoma patients., PMID:35651286
No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death., PMID:35608339
Diagnostic and prognostic values of pyroptosis-related genes for the hepatocellular carcinoma., PMID:35562678
Pyroptosis-Related Gene Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Glioma., PMID:35547808
Identification of the Pyroptosis-Related Prognosis Gene Signature and Immune Infiltration in Hepatocellular Carcinoma., PMID:35535333
The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation., PMID:35530130
Comprehensive Bioinformatics Analysis of Gasdermin Family of Glioma., PMID:35463276
Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C., PMID:35385697
Intravenous Delivery of Living Listeria monocytogenes Elicits Gasdmermin-Dependent Tumor Pyroptosis and Motivates Anti-Tumor Immune Response., PMID:35262333
Pyroptosis-related molecular classification and immune microenvironment infiltration in breast cancer: A novel therapeutic target., PMID:35233921
A pan-cancer analysis of the expression of gasdermin genes in tumors and their relationship with the immune microenvironment., PMID:35116710
Construction and validation of a novel pyroptosis-related signature to predict prognosis in patients with cutaneous melanoma., PMID:34903008
For research use only. Not for human or drug use.
