Catalog No.
RHN70902
Species reactivity
Human, Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IF: 1:50-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
hHIPk2, HIPK2, Homeodomain-interacting protein kinase 2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9H2X6
Applications
FCM, IF, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2Q64
The Intrabody Against Murine Double Minute 2 via a p53-Dependent Pathway Induces Apoptosis of Cancer Cell., PMID:40508092
HIPK2-T566 autophosphorylation diversely contributes to UV- and doxorubicin-induced HIPK2 activation., PMID:28060750
Tumor Suppressor HIPK2 Regulates Malignant Growth via Phosphorylation of Notch1., PMID:27335110
Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization., PMID:24196445
Activation of the interleukin-4/signal transducer and activator of transcription 6 signaling pathway and homeodomain-interacting protein kinase 2 production by tonsillar mononuclear cells in IgA nephropathy., PMID:24107646
HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation., PMID:23485397
Molecular targets for treatment of kidney fibrosis., PMID:23179685
SIAH-mediated ubiquitination and degradation of acetyl-transferases regulate the p53 response and protein acetylation., PMID:23044042
Tissue microarray cytometry reveals positive impact of homeodomain interacting protein kinase 2 in colon cancer survival irrespective of p53 function., PMID:21514416
Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs., PMID:21508668
Control of nuclear HIPK2 localization and function by a SUMO interaction motif., PMID:21145359
Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization., PMID:20637728
Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours., PMID:19603027
Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown., PMID:18483253
Gene Ontology-driven transcriptional analysis of CD34+ cell-initiated megakaryocytic cultures identifies new transcriptional regulators of megakaryopoiesis., PMID:18252802
Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis., PMID:15708980
The homeodomain-interacting kinase PKM (HIPK-2) modifies ND10 through both its kinase domain and a SUMO-1 interaction motif and alters the posttranslational modification of PML., PMID:12565818
A new expression cloning strategy for isolation of substrate-specific kinases by using phosphorylation site-specific antibody., PMID:11150545
The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells., PMID:11032752
Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors., PMID:9748262
For research use only. Not for human or drug use.
