Catalog No.
RHK36201
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000
Target
SAM domain and HD domain-containing protein 1, DCIP, Monocyte protein 5, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, MOP5, hSAMHD1, dNTPase, Dendritic cell-derived IFNG-induced protein, MOP-5, SAMHD1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9Y3Z3
Applications
FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2L84
Prognostic impact of genetic abnormalities in 536 first-line chronic lymphocytic leukaemia patients without 17p deletion treated with chemoimmunotherapy in two prospective trials: Focus on IGHV-mutated subgroups (a FILO study)., PMID:38654616
HUSH-mediated HIV silencing is independent of TASOR phosphorylation on threonine 819., PMID:36309692
SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide., PMID:34893529
Nucleotide Pool Imbalance and Antibody Gene Diversification., PMID:34696158
Restriction Factor Expression in Vertically Infected Children Living With HIV-1., PMID:33395209
Role of Complement Receptors (CRs) on DCs in Anti-HIV-1 Immunity., PMID:33224139
The impact of SAMHD1 expression and mutation status in mantle cell lymphoma: An analysis of the MCL Younger and Elderly trial., PMID:32638373
Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes., PMID:32584970
SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination., PMID:32511795
Co- but not Sequential Infection of DCs Boosts Their HIV-Specific CTL-Stimulatory Capacity., PMID:31178863
Multiple Autoimmune Disorders in Aicardi-Goutières Syndrome., PMID:30898416
SAMHD1 Suppression of Antiviral Immune Responses., PMID:30336972
[Familial chilblain lupus: Four cases spanning three generations]., PMID:30217686
SAMHD1 deficient human monocytes autonomously trigger type I interferon., PMID:30099227
DNA damage response signaling does not trigger redistribution of SAMHD1 to nuclear foci., PMID:29614270
DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1., PMID:29515139
Upregulation of Human Endogenous Retrovirus-K Is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension., PMID:28935667
Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHVmut and IgHVunmut subgroups., PMID:28584254
Tocilizumab reverses cerebral vasculopathy in a patient with homozygous SAMHD1 mutation., PMID:28289923
Development of monoclonal antibodies specifically recognizing the endogenous sterile alpha motif and HD domain 1 protein in porcine cell lines., PMID:25358004
Antibody-validated proteins in inflamed islets of fulminant type 1 diabetes profiled by laser-capture microdissection followed by mass spectrometry., PMID:25329145
Increased expression of SAMHD1 in a subset of HIV-1 elite controllers., PMID:25063780
Broadly neutralizing antibody VRC01 prevents HIV-1 transmission from plasmacytoid dendritic cells to CD4 T lymphocytes., PMID:24965460
17β-estradiol protects primary macrophages against HIV infection through induction of interferon-alpha., PMID:24801776
Dendritic cell-lymphocyte cross talk downregulates host restriction factor SAMHD1 and stimulates HIV-1 replication in dendritic cells., PMID:24574390
Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study., PMID:24183309
Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1., PMID:23966382
HIV type 1 infection of plasmacytoid and myeloid dendritic cells is restricted by high levels of SAMHD1 and cannot be counteracted by Vpx., PMID:23924154
Tactics used by HIV-1 to evade host innate, adaptive, and intrinsic immunities., PMID:23786957
Innate and Adaptive Immunity in Long-Term Non-Progression in HIV Disease., PMID:23630526
Innate immune sensing of HIV-1 by dendritic cells., PMID:23084911
SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations., PMID:22461318
Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome., PMID:20131292
Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants., PMID:12107410
For research use only. Not for human or drug use.
