Catalog No.
RHJ19601
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Target
NAD-dependent protein deacetylase sirtuin-2, Regulatory protein SIR2 homolog 2, SIR2-like protein 2, SIRT2, SIR2L2, SIR2L
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q8IXJ6
Applications
IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2J11
The Clinical Role of SIRT-3 in the Acute Rejection Process of Kidney Transplantation and Its Effects on Graft Outcomes: Evaluation of Biomarker Potential., PMID:40142268
Intraperitoneal Treatment of Cambinol, a Synthetic SIRT1 and SIRT2 Inhibitory Compound, Exacerbates Brucella abortus 544 Burden in the Spleens of Institute of Cancer Research Mice., PMID:39770737
Conditional Cell Penetration of Masked CPPs by an ADEPT-like Approach., PMID:38733564
Sirtuin 2 up-regulation suppresses the anti-tumour activity of exhausted natural killer cells in mesenteric lymph nodes in murine colorectal carcinoma., PMID:38441393
Metformin-induced reduction of CCR8 enhances the anti-tumor immune response of PD-1 immunotherapy in glioblastoma., PMID:38142852
Inflammatory related plasma proteins involved in acute preschool wheeze., PMID:38006384
Posttranslational modifications in psoriatic arthritis: A systematic literature review., PMID:37487969
Paraneoplastic or not? Sirtuin 2 in anti-N-methyl-d-aspartate receptor encephalitis., PMID:37483157
Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions., PMID:36937574
The cardioprotective role of sirtuins is mediated in part by regulating KATP channel surface expression., PMID:36878847
Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction., PMID:36719240
Protein succinylation associated with the progress of hepatocellular carcinoma., PMID:36308411
Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2., PMID:34961760
Highly sensitive detection of multiple proteins from single cells by MoS2-FET biosensors., PMID:34635229
Histone deacetylase SIR2 in Toxoplasma gondii modulates functions of murine macrophages in vitro and protects mice against acute toxoplasmosis in vivo., PMID:33731306
A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation., PMID:33360352
AGK2 ameliorates mast cell-mediated allergic airway inflammation and fibrosis by inhibiting FcεRI/TGF-β signaling pathway., PMID:32565308
Upregulation of circulating inflammatory biomarkers under the influence of periodontal disease in rheumatoid arthritis patients., PMID:32403006
Sirt2 epigenetically down-regulates PDGFRα expression and promotes CG4 cell differentiation., PMID:31020898
Monitoring of Protein Biomarkers of Inflammation in Human Traumatic Brain Injury Using Microdialysis and Proximity Extension Assay Technology in Neurointensive Care., PMID:31017044
Characterization of FOXO Acetylation., PMID:30414146
Redox modulation of NQO1., PMID:29298345
Membrane localization of acetylated CNK1 mediates a positive feedback on RAF/ERK signaling., PMID:28819643
NAMPT enzyme activity regulates catabolic gene expression in gingival fibroblasts during periodontitis., PMID:28819322
Mycoplasma fermentans deacetylase promotes mammalian cell stress tolerance., PMID:28602396
Molecular characterization and protective efficacy of silent information regulator 2A from Eimeria tenella., PMID:27884171
SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth., PMID:27197174
Activation of sirtuin 1/3 improves vascular hyporeactivity in severe hemorrhagic shock by alleviation of mitochondrial damage., PMID:26473372
Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes., PMID:25938585
Recombinant NAD-dependent SIR-2 protein of Leishmania donovani: immunobiochemical characterization as a potential vaccine against visceral leishmaniasis., PMID:25745863
Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis., PMID:25735751
Expression of SIRT2 and SIRT6 in retinoblastoma., PMID:25660418
SIRT2 Regulates LPS-Induced Renal Tubular CXCL2 and CCL2 Expression., PMID:25349202
Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging., PMID:24811750
Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD(+)-dependent deacetylases., PMID:24681949
A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity., PMID:24469059
Rosuvastatin Modulates the Post-Translational Acetylome in Endothelial Cells., PMID:27122770
SIRT2 directs the replication stress response through CDK9 deacetylation., PMID:23898190
Age-related susceptibility to apoptosis in human retinal pigment epithelial cells is triggered by disruption of p53-Mdm2 association., PMID:23139272
Prognostic significance of sirtuin 2 protein nuclear localization in glioma: an immunohistochemical study., PMID:22735931
Mechanism-based affinity capture of sirtuins., PMID:21184005
SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310., PMID:21081649
Transketolase and 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I isoforms are specifically recognized by IgG autoantibodies in multiple sclerosis patients., PMID:18676363
Global analysis of gel mobility of proteins and its use in target identification., PMID:18292091
Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation., PMID:17898715
Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing., PMID:17172643
Microtubule deacetylases, SirT2 and HDAC6, in the nervous system., PMID:16933150
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase., PMID:15795229
SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex., PMID:15498488
Okadaic acid mediates tau phosphorylation via sustained activation of the L-voltage-sensitive calcium channel., PMID:14559148
For research use only. Not for human or drug use.
