Catalog No.
RHH31301
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Target
BAK, Bcl2-L-7, BCL2L7, Apoptosis regulator BAK, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 7, CDN1, BAK1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q16611
Applications
IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2H17
Genomic and Phenotypic Characterization of CHO 4BGD Cells with Quad Knockout and Overexpression of Two Housekeeping Genes That Allow for Metabolic Selection and Extended Fed-Batch Culturing., PMID:40422195
A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells., PMID:38582955
Novel chimeric antigen receptor-expressing T cells targeting the malignant mesothelioma-specific antigen sialylated HEG1., PMID:38212893
A preliminary, prospective study of peripheral neuropathy and cognitive function in patients with breast cancer during taxane therapy., PMID:36206298
Podocytes are lost from glomeruli before completing apoptosis., PMID:36049065
The RECEPTOR-LIKE PROTEIN53 immune complex associates with LLG1 to positively regulate plant immunity., PMID:35796320
Engineering death resistance in CHO cells for improved perfusion culture., PMID:35737825
In vitro evolution of antibody affinity via insertional scanning mutagenesis of an entire antibody variable region., PMID:33067389
Evaluation of the upregulation and surface expression of hypoxanthine guanine phosphoribosyltransferase in acute lymphoblastic leukemia and Burkitt's B cell lymphoma., PMID:32782434
Shikonin induces tumor apoptosis in glioma cells via endoplasmic reticulum stress, and Bax/Bak mediated mitochondrial outer membrane permeability., PMID:32663591
Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma., PMID:32054850
Stable expression of infliximab in CRISPR/Cas9-mediated BAK1-deficient CHO cells., PMID:29915899
Mechanisms of platelet clearance and translation to improve platelet storage., PMID:29475962
Alcoholic hepatitis versus non-alcoholic steatohepatitis: Levels of expression of some proteins involved in tumorigenesis., PMID:29307797
Repression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couple ER stress to mitochondrial apoptosis., PMID:27697610
Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies., PMID:27217060
FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling., PMID:26093985
Mitochondrial p53 phosphorylation induces Bak-mediated and caspase-independent cell death., PMID:25980443
Proapoptotic activities of protein disulfide isomerase (PDI) and PDIA3 protein, a role of the Bcl-2 protein Bak., PMID:25697356
Interaction between Na-K-ATPase and Bcl-2 proteins BclXL and Bak., PMID:25318106
Tumor suppressor protein p53 promotes 2-methoxyestradiol-induced activation of Bak and Bax, leading to mitochondria-dependent apoptosis in human colon cancer HCT116 cells., PMID:25179905
HIV-1 Tat-mediated apoptosis in human blood-retinal barrier-associated cells., PMID:24739951
Structural basis for flg22-induced activation of the Arabidopsis FLS2-BAK1 immune complex., PMID:24114786
The novel proteasome inhibitor carfilzomib induces cell cycle arrest, apoptosis and potentiates the anti-tumour activity of chemotherapy in rituximab-resistant lymphoma., PMID:23826755
Prometaphase arrest-dependent phosphorylation of Bcl-2 family proteins and activation of mitochondrial apoptotic pathway are associated with 17α-estradiol-induced apoptosis in human Jurkat T cells., PMID:23707954
The BH3-only protein Bim(L) overrides Bcl-2-mediated apoptosis resistance in melanoma cells., PMID:23402819
Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease., PMID:23349374
The proteasome inhibitor MG132 potentiates TRAIL receptor agonist-induced apoptosis by stabilizing tBid and Bik in human head and neck squamous cell carcinoma cells., PMID:22513214
Histone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells., PMID:22341071
Delineation of apoptotic genes for synergistic apoptosis of lexatumumab and anthracyclines in human renal cell carcinoma cells by polymerase chain reaction array., PMID:22205156
Distinct cellular and therapeutic effects of obatoclax in rituximab-sensitive and -resistant lymphomas., PMID:21492126
Blockade of interleukin-6 signalling with siltuximab enhances melphalan cytotoxicity in preclinical models of multiple myeloma., PMID:21241278
Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo., PMID:20855960
Fas apoptosis inhibitory molecule regulates T cell receptor-mediated apoptosis of thymocytes by modulating Akt activation and Nur77 expression., PMID:20178987
The glycoprotein Ibalpha-von Willebrand factor interaction induces platelet apoptosis., PMID:19840363
BEX2 regulates mitochondrial apoptosis and G1 cell cycle in breast cancer., PMID:19711341
The VDAC2-BAK rheostat controls thymocyte survival., PMID:19706873
Deficient activation of Bak and Bax confers resistance to gemtuzumab ozogamicin-induced apoptotic cell death in AML., PMID:19463775
Antiapoptotic small interfering RNA as potent adjuvant of DNA vaccination in a mouse mammary tumor model., PMID:19222350
BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells., PMID:19118042
Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes., PMID:19003879
Down-regulation of Mcl-1 with antisense technology alters the effect of various cytotoxic agents used in treatment of squamous cell carcinoma of the head and neck., PMID:18497956
Acquired resistance to rituximab is associated with chemotherapy resistance resulting from decreased Bax and Bak expression., PMID:18316580
Histone H1.2 is translocated to mitochondria and associates with Bak in bleomycin-induced apoptotic cells., PMID:17879944
Radiation-induced apoptosis along with local and systemic cytokine elaboration is associated with DC plus radiotherapy-mediated renal cell tumor regression., PMID:17449328
Bax does not have to adopt its final form to drive T cell death., PMID:16651384
Inhibition of staurosporine-induced activation of the proapoptotic multidomain Bcl-2 proteins Bax and Bak by three invasive chlamydial species., PMID:16490255
Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death., PMID:16332536
Immunogenetics of primary Sjögren's syndrome in Colombians., PMID:15846589
Bcl-xl and Bak protein expression in human optic nerve axons in eyeballs post-trauma and in the eyes with absolute glaucoma., PMID:15638362
For research use only. Not for human or drug use.
