Catalog No.
RHG61601
Species reactivity
Human, Rat, Hamster
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:100, WB: 1:500-1:1000
Target
Cullin-4B, CUL-4B, CUL4B, KIAA0695
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q13620
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2E84
Enhancing anti-tumor immunity of natural killer cells through targeting IL-15R signaling., PMID:40513576
Reciprocal Regulation Between the SCF FBXO24 Ubiquitin E3 Ligase and FoxP1 Protein., PMID:40501863
The Mechanism of Histone Ubiquitylation by the ASB9-CUL5 Ubiquitin Ligase., PMID:40501794
FUNCTIONAL ANALYSIS OF BIPARTITE NRF2 ACTIVATORS THAT OVERCOME FEEDBACK REGULATION FOR AGE-RELATED CHRONIC DISEASES., PMID:40501562
Inhibiting neddylation: A new strategy for tumor therapy., PMID:40496066
Structural basis for L-isoaspartyl-containing protein recognition by the PCMTD1 cullin-RING E3 ubiquitin ligase., PMID:40475564
Biochemical analysis of PD-L1 ubiquitination by CRL3SPOP, ARIH1, and NEDD4 family ubiquitin ligases., PMID:40472843
Molecular hybridization strategy - discovery of 2,3-diarylpyrazine derivatives as potent Skp2 inhibitors with improved anti-tumor activity and enhanced cisplatin sensitivity., PMID:40460720
Expression and purification of functional recombinant Cullin1-Rbx1/2 in E. coli., PMID:40447239
Role of the Renin-Angiotensin System in Blood Pressure Regulation in Smooth Muscle-Specific Cullin-3 Deficient Mice., PMID:40440505
Crosstalk between SUMOylation and ubiquitination controls the stability of transcription factor zinc finger protein 24: a novel antitumor mechanism in bladder cancer., PMID:40437183
MLN4924 suppresses tumor metabolism and growth of clear cell renal cell carcinoma by stabilizing nuclear FBP1., PMID:40419474
Identification and validation of USP15 and CUL2 as ubiquitination related biomarker in chronic obstructive pulmonary disease., PMID:40413536
Cullin 3-mediated ubiquitination restricts enterovirus D68 replication and is counteracted by viral protease 3C., PMID:40396757
Rewired glycolysis by DTL accelerates oncometabolite L-lactate generation to promote breast cancer progression., PMID:40391156
Gene model for the ortholog of Roc1a in Drosophila persimilis., PMID:40385375
Discovery of an NF-κB1 p105 Degrader for Anti-Inflammatory Therapy via Structural Optimization of the Coumarin Natural Product Minutuminolate., PMID:40378174
Regulator of cullins-1 predicts a poor prognosis and regulates epithelial-mesenchymal transition process through GSK-3β/Wnt signaling in renal cell carcinoma., PMID:40376526
Recessive variants in WSB2 encoding a substrate receptor of E3 ubiquitin ligase underlie a neurodevelopmental syndrome., PMID:40374945
[Genetic analysis of a case of Miller-McKusick-Malvaux syndrome type 1 caused by CUL7 gene variant and a literature review]., PMID:40372227
Redox-driven regulation of UCHL3/Yuh1 influences mitochondrial health via the NEDD8/Rub1 pathway., PMID:40347692
Biomarkers of Skeletal Muscle Atrophy Based on Atrogenes Evaluation: A Systematic Review and Meta-Analysis Study., PMID:40331994
Insights into the target-directed miRNA degradation mechanism in Drosophila ovarian cell culture., PMID:40328417
Circ_0003520/miR-205-5p/CUL4B Axis Drives the Progression of Clear Cell Renal Carcinoma., PMID:40320861
FBXO38 Regulates Nox1 Stability to Reduce Vascular Endothelial Damage Induced by Low Oscillatory Shear Stress., PMID:40313652
Illuminating ubiquitination mechanisms: How cryo-EM has shed light on Cullin RING E3 ligase function., PMID:40311545
Chromatin-associated cullin-RING E3 ubiquitin ligases: keeping transcriptionally active NF-κB in check., PMID:40308609
F-box protein FBXO32 ubiquitinates and stabilizes D-type cyclins to drive cancer progression., PMID:40307251
Allelic effects on KLHL17 expression underlie a pancreatic cancer genome-wide association signal at chr1p36.33., PMID:40307206
Cullin-RING Ubiquitin Ligases in Neurodevelopment and Neurodevelopmental Disorders., PMID:40299365
Glycosylation Weakens Skp1 Homodimerization in Toxoplasma gondii by Interrupting a Fuzzy Interaction., PMID:40296701
Deciphering the roles of neddylation modification in hepatocellular carcinoma: Molecular mechanisms and targeted therapeutics., PMID:40290125
Vitamin D deficiency promotes intervertebral disc degeneration via p38/NCoR2-mediated extracellular matrix degradation., PMID:40274653
Stabilization of GTSE1 by cyclin D1-CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosis., PMID:40272409
TOM20-driven E3 ligase recruitment regulates mitochondrial dynamics through PLD6., PMID:40263465
Discovery of a novel molecular glue degrader targeting GSPT1/2 with a non-IMiD-based CRBN binder., PMID:40252382
Markers of Negative Emotionality in Individuals With Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder: Role of Childhood Trauma., PMID:40250452
Belt Electrode-Skeletal Muscle Electrical Stimulation Prevents Muscle Atrophy in the Soleus of Collagen-Induced Arthritis Rats., PMID:40244146
Identification of new candidates regulating autophagy-dependent midgut degradation in Drosophila melanogaster., PMID:40240351
The essential role of E3 ubiquitin ligases in the pathogenesis of neurodevelopmental and psychiatric disorders: Cul3, Cul4, Ube3a, and ZNRF1., PMID:40233431
Elucidating the immunomodulatory roles and mechanisms of CUL4B in the immune system: a comprehensive review., PMID:40230836
Mechanistic Insights Into the Assembly of Functional CRL3 Dimeric Complexes., PMID:40211562
Manipulation of targeted protein degradation in plant biology., PMID:40209052
Neddylation modification stabilizes LC3B by antagonizing its ubiquitin-mediated degradation and promoting autophagy in skin., PMID:40208944
The tumor suppressor LZTR1: Its expression, purification and characterization., PMID:40204202
CUL4B regulates thyroid cancer differentiation and treatment sensitivity by ubiquitinating ARID1A., PMID:40203790
Sequence rules for a long SPOP-binding degron required for protein ubiquitylation., PMID:40178506
Discovery of a Novel CUL3 Variant: Unveiling Epilepsy and Newly Associated Dysmorphic Traits in a Turkish Patient., PMID:40176836
Cereblon E3 ligase complex genes are expressed in tissues sensitive to thalidomide in chicken and zebrafish embryos but are unchanged following thalidomide exposure., PMID:40158790
NSUN2 promotes colorectal cancer progression and increases lapatinib sensitivity by enhancing CUL4B/ErbB-STAT3 signalling in a non-m5C manner., PMID:40156167
For research use only. Not for human or drug use.
