Anti-RBPJ Antibody (R2C85)

Catalog No.

RHG08601

Species reactivity

Rat

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

WB: 1:500-1:1000

Target

Recombining binding protein suppressor of hairless, RBP-J, IGKJRB, CBF-1, J kappa-recombination signal-binding protein, RBP-J kappa, RBP-JK, IGKJRB1, RBPJ, Renal carcinoma antigen NY-REN-30, RBPSUH, RBPJK

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q06330

Applications

WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R2C85

Immunosuppressive JAG2+ tumor-associated neutrophils hamper PD-1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells., PMID:40120139

Autoantibody profiling of patients with immune checkpoint inhibitor-associated myocarditis: a pilot study., PMID:39324142

NOTCH2 sensitizes the chondrocyte to the inflammatory response of tumor necrosis factor α., PMID:37865314

Targeted inhibition of RBPJ transcription complex alleviates the exhaustion of CD8+ T cells in hepatocellular carcinoma., PMID:36717584

miR-375 upregulates lipid metabolism and inhibits cell proliferation involved in chicken fatty liver formation and inheritance via targeting recombination signal binding protein for immunoglobulin kappa J region (RBPJ)., PMID:36410068

Notch effector recombination signal binding protein for immunoglobulin kappa J signaling is required for the initiation of endometrial stromal cell decidualization†., PMID:35835555

Tumor-associated macrophages (TAMs) modulate response to HER2-targeted agents in a humanized mouse model of breast cancer., PMID:35212924

Pharmacological disruption of the Notch transcription factor complex., PMID:32601208

M2-Polarized Macrophages Determine Human Cutaneous Lesions in Lacaziosis., PMID:32378114

Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes., PMID:29889863

The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI., PMID:28877478

Notch2 blockade enhances hematopoietic stem cell mobilization and homing., PMID:28729299

G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling., PMID:27926858

Notch3 drives development and progression of cholangiocarcinoma., PMID:27791012

Central role for marginal zone B cells in an animal model of Sjogren's syndrome., PMID:27140729

Notch 1 and Notch 2 synergistically regulate the differentiation and function of invariant NKT cells., PMID:26188077

Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence., PMID:25385755

Hes1 suppresses acute myeloid leukemia development through FLT3 repression., PMID:25234168

Notch-dependent RBPJκ inhibits proliferation of human cytotrophoblasts and their differentiation into extravillous trophoblasts., PMID:24850908

Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis., PMID:23921886

The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation., PMID:23698100

Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development., PMID:23319657

Immunohistochemical analysis of medullary breast carcinoma autoantigens in different histological types of breast carcinomas., PMID:23181716

Notch-RBP-J-independent marginal zone B cell development in IgH transgenic mice with VH derived from a natural polyreactive antibody., PMID:22719978

Serum autoantibody signature of ductal carcinoma in situ progression to invasive breast cancer., PMID:22322670

Direct regulation of interleukin-6 expression by Notch signaling in macrophages., PMID:21983868

Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo., PMID:21898486

Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac., PMID:21352545

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci., PMID:20453842

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin., PMID:20174635

Reduced notch activity is associated with an impaired marginal zone B cell development and function in Sly1 mutant mice., PMID:18950867

Epstein-Barr virus nuclear antigen 2 induces FcRH5 expression through CBF1., PMID:16439682

A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 independent., PMID:15994772

Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells., PMID:15879553

Quantification of Jkappa signal end breaks in developing B cells by blunt-end linker ligation and qPCR., PMID:15680147

Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways., PMID:14701863

Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling., PMID:12832621

[LIM protein KyoT2 interacts with human tight junction protein ZO-2-i3]., PMID:12645256

Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells., PMID:11967543

[Screening and detecting of proteins interaction with KyoT]., PMID:11902002

Characterization of tissue-specific LIM domain protein (FHL1C) which is an alternatively spliced isoform of a human LIM-only protein (FHL1)., PMID:11400158

Notch signaling as a target in multimodality cancer therapy., PMID:11249652

Detection of a potent humoral response associated with immune-induced remission of chronic myelogenous leukemia., PMID:10974024

Regulation of the Epstein-Barr virus C promoter by AUF1 and the cyclic AMP/protein kinase A signaling pathway., PMID:10933728

Functional interactions between an atypical NF-kappaB site from the rat CYP2B1 promoter and the transcriptional repressor RBP-Jkappa/CBF1., PMID:10773077

Activated Notch1 modulates gene expression in B cells similarly to Epstein-Barr viral nuclear antigen 2., PMID:10644343

Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells., PMID:10637481

Enhanced expression and autoimmunity of recombination signal binding protein-jkappa in human dilated cardiomyopathy., PMID:10600520

CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex., PMID:9874765

Delta-1 activation of notch-1 signaling results in HES-1 transactivation., PMID:9819428

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