Catalog No.
RHF88901
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:100-1:200, WB: 1:1000-1:2000
Target
MSH-R, MSHR, Melanocyte-stimulating hormone receptor, Melanocortin receptor 1, MC1R, MC1-R
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q01726
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2B98
Hydrolyzed cow colostrum extract (BCFM) inhibits alpha-MSH-induced melanogenesis in B16F1 cells via regulation of the MC1R-cAMP signaling pathway., PMID:39435419
Novel deoxyhypusine synthase (DHPS) inhibitors target hypusination-induced vasculogenic mimicry (VM) against malignant melanoma., PMID:39393437
Peripheral MC1R Activation Modulates Immune Responses and is Neuroprotective in a Mouse Model of Parkinson's Disease., PMID:38110615
Melanocortin 1 receptor (MC1R) expression as a marker of progression in melanoma., PMID:37790306
Peripheral MC1R activation modulates immune responses and is neuroprotective in a mouse model of Parkinson's disease., PMID:37398302
Negative Modulation of B Cell Activation by Melanocortin 1 Receptor Signaling Protects against Membranous Nephropathy., PMID:36446431
Measurement of Melanin Metabolism in Live Cells by [U-13C]-L-Tyrosine Fate Tracing Using Liquid Chromatography-Mass Spectrometry., PMID:33549605
Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity., PMID:33376202
Evaluation of the upregulation and surface expression of hypoxanthine guanine phosphoribosyltransferase in acute lymphoblastic leukemia and Burkitt's B cell lymphoma., PMID:32782434
Topical MTII Therapy Suppresses Melanoma Through PTEN Upregulation and Cyclooxygenase II Inhibition., PMID:31968661
A flow-through microfluidic system for the detection of circulating melanoma cells., PMID:31336226
A tumor-targeted immune checkpoint blocker., PMID:31332018
α-Melanocyte-Stimulating Hormone Attenuates Neovascularization by Inducing Nitric Oxide Deficiency via MC-Rs/PKA/NF-κB Signaling., PMID:30513637
Exploring pathways for sustained melanogenesis in facial melasma: an immunofluorescence study., PMID:29846953
Ultrasensitive electrochemical immunoassay for melanoma cells using mesoporous polyaniline., PMID:29299559
New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut., PMID:29152323
Melanocortin-1 Receptor-Targeting Ultrasmall Silica Nanoparticles for Dual-Modality Human Melanoma Imaging., PMID:29058865
Melanocortin receptor subtypes are expressed on cells in the oligodendroglial lineage and signal ACTH protection., PMID:28877366
Melanocortin 2, 3 and 4 Receptor Gene Expressions are Downregulated in CD8+ T Cytotoxic Lymphocytes and CD19+ B Lymphocytes in Rheumatoid Arthritis Responding to TNF-α Inhibition., PMID:28426141
Regulation of melanocortin 1 receptor in allergic rhinitis in vitro and in vivo., PMID:27196703
Dimerization of melanocortin receptor 1 (MC1R) and MC5R creates a ligand-dependent signal modulation: Potential participation in physiological color change in the flounder., PMID:27080548
Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5., PMID:25860801
An electrochemical immunosensing method for detecting melanoma cells., PMID:25636023
Increased corticotropin-releasing hormone (CRH) expression in cutaneous lupus lesions., PMID:25634068
Melanocortin receptor accessory protein 2 (MRAP2) interplays with the zebrafish melanocortin 1 receptor (MC1R) but has no effect on its pharmacological profile., PMID:24709359
α-Melanocyte-stimulating hormone inhibits angiogenesis through attenuation of VEGF/VEGFR2 signaling pathway., PMID:24530634
The effect of MC1R variants and sunscreen on the response of human melanocytes in vivo to ultraviolet radiation and implications for melanoma., PMID:23962207
A bioassay for the detection of neutralizing antibodies against the α-melanocyte stimulating hormone analog afamelanotide in patients with erythropoietic protoporphyria., PMID:23277150
Agouti revisited: transcript quantification of the ASIP gene in bovine tissues related to protein expression and localization., PMID:22530003
A global analysis of molecular markers and phenotypic traits in local chicken breeds in Taiwan., PMID:22404353
MSH radiopeptides for targeting melanoma metastases., PMID:21222266
Alpha-melanocyte-stimulating hormone plays an important role in the onset of pollinosis in a pollen allergy mouse model., PMID:20357480
Patients affected by vitiligo and autoimmune diseases do not show antibodies interfering with the activity of the melanocortin 1 receptor., PMID:20332705
Demonstration of the proopiomelanocortin signaling system in the primary immune organ of the quail., PMID:19456381
Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for diagnosis and immunotherapy., PMID:17325166
[D-Trp8]-gamma-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse)., PMID:16959942
Quantitative analysis of MC1R gene expression in human skin cell cultures., PMID:16420249
Detection of functionally active melanocortin receptors and evidence for an immunoregulatory activity of alpha-melanocyte-stimulating hormone in human dermal papilla cells., PMID:16081629
Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk., PMID:15972726
Expression of c-Met proto-oncogene in metastatic macrophage x melanoma fusion hybrids: implication of its possible role in MSH-induced motility., PMID:14760865
Expression of melanocortin-1 receptor in normal, malformed and neoplastic skin glands and hair follicles., PMID:11952827
The effect of thioredoxin on the expression of proopiomelanocortin-derived peptides, the melanocortin 1 receptor and cell survival of normal human keratinocytes., PMID:11764282
Characterization of a polyclonal antibody raised against the human melanocortin-1 receptor., PMID:10816669
Detection of melanocortin-1 receptor antigenicity on human skin cells in culture and in situ., PMID:10597134
The effect of ultraviolet B induced adult T cell leukemia-derived factor/thioredoxin (ADF/TRX) on survival and growth of human melanocytes., PMID:9170166
Immunohistochemical detection of the melanocortin 1 receptor in human testis, ovary and placenta using specific monoclonal antibody., PMID:9362391
Expression of functional melanocortin 1 receptors in insect cells., PMID:8630043
For research use only. Not for human or drug use.
