Catalog No.
RHF86102
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Target
Core-binding factor subunit alpha-2, CBF-alpha-2, CBFA2, SL3-3 enhancer factor 1 alpha B subunit, Runt-related transcription factor 1, RUNX1, Oncogene AML-1, Polyomavirus enhancer-binding protein 2 alpha B subunit, PEBP2-alpha B, SL3/AKV core-binding factor alpha B subunit, AML1, PEA2-alpha B, Acute myeloid leukemia 1 protein
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q01196, Q13761, Q13950
Applications
IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2B90
Case Report: Rapid response to gemtuzumab-ozogamicin in a pediatric patient with refractory systemic mastocytosis with AML1::ETO+ acute myeloid leukemia., PMID:40270973
Coexistence of acute myeloid leukemia with a complex chromosomal translocation and monoclonal gammopathy of undetermined significance: A case report and literature review., PMID:40110581
Haploidentical Hematopoietic Cell Transplantation in Dyskeratosis Congenita with Myelodysplastic Syndrome/Acute Myeloid Leukemia., PMID:40061174
Transcription factor RUNX1 regulates coagulation factor XIII-A (F13A1): decreased platelet-megakaryocyte F13A1 expression and clot contraction in RUNX1 haplodeficiency., PMID:39995753
Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke., PMID:39831706
A Rare Case of a Malignant Proliferating Trichilemmal Tumor: A Molecular Study Harboring Potential Therapeutic Significance and a Review of Literature., PMID:39727620
Blinatumomab as postremission therapy replaces consolidation and substantial parts of maintenance chemotherapy and results in stable MRD negativity in children with newly diagnosed B-lineage ALL., PMID:38844406
Altered platelet-megakaryocyte endocytosis and trafficking of albumin and fibrinogen in RUNX1 haplodeficiency., PMID:38330198
Runx1 is upregulated by STAT3 and promotes proliferation of neonatal rat cardiomyocytes., PMID:38040660
Presence of leukemic clone-specific immunoglobulin heavy chain rearrangements in neonatal blood spots of children with B-cell precursor acute lymphoblastic leukemia., PMID:37929321
Antibody-Based and Cell Therapies for Advanced Mastocytosis: Established and Novel Concepts., PMID:37894806
Scutellarin suppresses the metastasis of triple-negative breast cancer via targeting TNFα/TNFR2-RUNX1-triggered G-CSF expression in endothelial cells., PMID:37716622
Neutrophil Activation and Immune Thrombosis Profiles Persist in Convalescent COVID-19., PMID:36943669
Molecular Classification and Overcoming Therapy Resistance for Acute Myeloid Leukemia with Adverse Genetic Factors., PMID:35682627
Case Report: Preemptive Treatment With Low-Dose PD-1 Blockade and Azacitidine for Molecular Relapsed Acute Myeloid Leukemia With RUNX1-RUNX1T1 After Allogeneic Hematopoietic Stem Cell Transplantation., PMID:35185899
IL-6 coaxes cellular dedifferentiation as a pro-regenerative intermediate that contributes to pericardial ADSC-induced cardiac repair., PMID:35101092
Regeneration of immunocompetent B lymphopoiesis from pluripotent stem cells guided by transcription factors., PMID:34893754
Immunonano-Lipocarrier-Mediated Liver Sinusoidal Endothelial Cell-Specific RUNX1 Inhibition Impedes Immune Cell Infiltration and Hepatic Inflammation in Murine Model of NASH., PMID:34445195
Comparison of Two Quantitative PCR-Based Assays for Detection of Minimal Residual Disease in B-Precursor Acute Lymphoblastic Leukemia Harboring Three Major Fusion Transcripts., PMID:34325057
Effects of Estradiol on Immunoglobulin G Glycosylation: Mapping of the Downstream Signaling Mechanism., PMID:34113353
Pure Red Cell Aplasia following ABO-Mismatched Allogeneic Hematopoietic Stem Cell Transplantation: Resolution with Daratumumab Treatment., PMID:33887733
Emerging therapies for inv(16) AML., PMID:33821975
Somatic Mutations and the Risk of Undifferentiated Autoinflammatory Disease in MDS: An Under-Recognized but Prognostically Important Complication., PMID:33679746
Targeted Dual Small Interfering Ribonucleic Acid Delivery via Non-Viral Polymeric Vectors for Pulmonary Fibrosis Therapy., PMID:33604928
Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia., PMID:33400146
Mechanisms of miR‑128‑3p in inhibiting osteoblast differentiation from bone marrow‑derived mesenchymal stromal cells., PMID:33174052
Concomitant use of a dual Src/ABL kinase inhibitor eliminates the in vitro efficacy of blinatumomab against Ph+ ALL., PMID:32898857
Clinical and immunological features of platelet transfusion refractoriness in young patients with de novo acute myeloid leukemia., PMID:32419364
Runx1 up-regulates chondrocyte to osteoblast lineage commitment and promotes bone formation by enhancing both chondrogenesis and osteogenesis., PMID:32391876
Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases., PMID:32128391
Neoantigens in Hematologic Malignancies., PMID:32117272
Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition., PMID:31996681
EZH2 deficiency attenuates Treg differentiation in rheumatoid arthritis., PMID:31952907
RUNX1 mutation in a patient with myelodysplastic syndrome and decreased erythrocyte expression of blood group A antigen., PMID:31840280
Validation of an enzyme-linked immunosorbent assay (ELISA) for quantification of endostatin levels in mice as a biomarker of developing glomerulonephritis., PMID:31404120
T-lymphoid/myeloid mixed phenotype acute leukemia and early T-cell precursor lymphoblastic leukemia similarities with NOTCH1 mutation as a good prognostic factor., PMID:31118806
Analysis of the proteasome activity and the turnover of the serotonin receptor 2B (HTR2B) in human uveal melanoma., PMID:31002821
The Incidence and Immunophenotypic and Genetic Features of JL1 Expressing Cells and the Therapeutic Potential of an Anti-JL1 Antibody in De Novo Pediatric Acute Leukemias., PMID:30809981
Flow cytometric predictive scoring systems for common fusions ETV6/RUNX1, BCR/ABL1, TCF3/PBX1 and rearrangements of the KMT2A gene, proposed for the initial cytogenetic approach in cases of B-acute lymphoblastic leukemia., PMID:30730614
Downregulation of TREM-like transcript-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia., PMID:30545930
RUNX1 Mutations Can Lead to Aberrant Expression of CD79a and PAX5 in Acute Myelogenous Leukemias: A Potential Diagnostic Pitfall., PMID:30396184
Rasip1 is a RUNX1 target gene and promotes migration of NSCLC cells., PMID:30349386
[AML in Adults - An Update on Diagnosis, Risk Classification and Therapy]., PMID:30199909
Loss of runx1 function results in B cell immunodeficiency but not T cell in adult zebrafish., PMID:30045885
Cells with hematopoietic potential reside within mouse proepicardium., PMID:29549430
[Chemotherapy for a child with relapsed acute myeloid leukemia complicated with persistent hepatitis C virus infection]., PMID:28679992
Disruption of the aortic wall by coelomic lining-derived mesenchymal cells accompanies the onset of aortic hematopoiesis., PMID:28621430
Runx1 stabilizes the mammary epithelial cell phenotype and prevents epithelial to mesenchymal transition., PMID:28407681
The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia., PMID:27611867
FGFR2IIIb-MAPK Activity Is Required for Epithelial Cell Fate Decision in the Lower Müllerian Duct., PMID:27164167
For research use only. Not for human or drug use.
