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Anti-MSH6 Antibody (R1Y61)

Catalog #:   RHE93102 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: IF, IHC, WB
Accession: P52701
Overview

Catalog No.

RHE93102

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

IF: 1:50-1:200, IHC: 1:50-1:100, WB: 1:500-1:1000

Target

DNA mismatch repair protein Msh6, MutS protein homolog 6, MSH6, GTBP, hMSH6, GTMBP, G/T mismatch-binding protein, MutS-alpha 160 kDa subunit, p160

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P52701

Applications

IF, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R1Y61

Data Image
  • Immunofluorescence
    Immunocytochemistry analysis of MSH6(green) in Hela using MSH6 antibody,and DAPI(blue)
  • Immunohistochemical
    Immunohistochemistry analysis of paraffin-embedded Human tonsil using MSH6 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
  • Western blot
    Western blot analysis of MSH6 in K562, C6, 3T3, Hela lysates using MSH6 antibody.
References

Immunohistochemical and molecular evolutionary features of jejunoileal adenocarcinoma unveiled through comparative analysis with colorectal adenocarcinoma., PMID:40403397

Detecting microsatellite instability in cancer via multiplexed orthogonal gap-enhanced Raman tags., PMID:40386153

Microsatellite Status, Tumor Budding, CD3 and CD8 T Cell Densities in Relation to Invasiveness, Lymph Node Involvement in Colorectal Adenocarcinoma., PMID:40263681

Comparison of survival outcomes for patients with Lynch vs non-Lynch syndrome and microsatellite unstable colorectal cancer treated with immunotherapy., PMID:39932790

Case report: Chemotherapy plus sintilimab for the treatment of gastroesophageal junction hepatoid adenocarcinoma with liver metastasis: a case study with literature review., PMID:39931054

[Application of PMS2 and MSH6 double-antibody detection in screening of mismatch repair deficient tumors]., PMID:39863527

Mismatch Repair Proficient Colorectal Adenocarcinoma in Two Patients With Lynch Syndrome., PMID:39660603

Simplifying Mismatch Repair Deficiency Screening in Endometrial Adenocarcinoma: Immunohistochemistry with Two-Antibody Panel (PMS2 and MSH6)., PMID:39471035

Intraoperative rapid immunohistochemistry of microsatellite instability using non-contact alternating current electric field mixing., PMID:39443409

Gaucher-like crystal-storing histiocytosis associated with kappa chain myeloma: A case report with next generation sequencing study., PMID:39357187

Single Center Characterization of a Cohort of Salivary Gland Carcinomas., PMID:39337873

Universal testing in endometrial cancer in Sweden., PMID:39175077

Intriguing Insights From 100 Consecutive Colorectal Cancer Cases in Mid-Kerala: Sparse BRAF Gene Mutations and Mismatch Repair Deficiency (MMR-D)., PMID:39119381

Comparison of antigenicity between frozen section vs non-frozen section tissue blocks: An immunohistochemical study of antibodies commonly used in gynecologic pathology., PMID:39110415

Analysis of translesion polymerases in colorectal cancer cells following cetuximab treatment: A network perspective., PMID:39102671

Mismatch repair deficiency: how reliable is the two-antibody approach? A national real-life study., PMID:38859771

Diagnostic and prognostic assessments of adrenocortical carcinomas by pathological features, immunohistochemical markers and reticular histochemistry staining., PMID:38802933

Assessing Mismatch Repair Expression by Immunohistochemistry in Colorectal Adenocarcinoma -Insight from a Tertiary Care Centre., PMID:38774931

The Relationship of Microsatellite Instability with BRAF and p53 Mutations and Histopathological Parameters in Colorectal Adenocarcinoma., PMID:38684491

[Expression of immune checkpoints PD-L1, CTLA4, LAG3 in the microenvironment of colon adenocarcinoma depending on MMR status]., PMID:38591901

HER2-low and Overexpression in Mucinous Ovarian Cancer: Analysis of ASCO/CAP and ToGA Immunohistochemical Scoring., PMID:38436360

Clinicopathological features and evaluation of microsatellite stability of colorectal carcinoma with cribriform comedo pattern., PMID:38394410

Next-generation sequencing and immunohistochemistry approaches for microsatellite instability detection in endometrial cancer., PMID:38279425

The relationship between DNA mismatch repair gene and other prognostic parameters in pancreatic adenocarcinoma., PMID:38173349

Clinicopathologic features of conjunctival MALT lymphomas refractory to radiation therapy., PMID:38101452

Expression of Programmed Cell Death Ligand-1 and Mismatch Repair Status in Endometrial Carcinomas., PMID:38029026

Deficient Mismatch Repair Proteins in Gastric Mixed Neuroendocrine Non-Neuroendocrine Neoplasm: A Rare Case Report., PMID:37900850

Phase II Trial of Nivolumab in Metastatic Rare Cancer with dMMR or MSI-H and Relation with Immune Phenotypic Analysis (the ROCK Trial)., PMID:37819940

Deep Learning Can Predict Bevacizumab Therapeutic Effect and Microsatellite Instability Directly from Histology in Epithelial Ovarian Cancer., PMID:37741509

Mismatch Repair Deficient (dMMR) Colorectal Carcinoma in a Pakistani Cohort: Association With Clinical and Pathological Parameters., PMID:37664303

Mismatch Repair Protein Expression in Endometrial Cancer: Assessing Concordance and Unveiling Pitfalls in Two Different Immunohistochemistry Assays., PMID:37623510

Early-Onset/Young-Onset Colorectal Carcinoma: A Comparative Analysis of Morphological Features and Biomarker Profile., PMID:37621838

Using Proteome Microarray and Gene Expression Omnibus Database to Screen Tumour-Associated Antigens to Construct the Optimal Diagnostic Model of Oesophageal Squamous Cell Carcinoma., PMID:37433700

A Japanese case of ovarian mucinous adenocarcinoma with germline double variants of MSH2 and BRCA2., PMID:37420004

Mixed acinar-neuroendocrine carcinoma of the pancreas with positive for microsatellite instability: a case report and review of the literature., PMID:37386324

MTHFR act as a potential cancer biomarker in immune checkpoints blockades, heterogeneity, tumor microenvironment and immune infiltration., PMID:37354330

The expression of programmed death-ligand 1 and programmed death-ligand 2 in endometrial carcinosarcoma: Correlation with mismatch repair protein expression status, tumor-infiltrating lymphocyte infiltration, and clinical outcomes., PMID:37060883

Predictive biomarkers of immunotherapy response with pharmacological applications in solid tumors., PMID:37055532

Complete Response to Immune Checkpoint Inhibition in a Platinum Resistant Primary Ovarian Cancer Patient With Lynch Syndrome: A Case Report and Review of the Literature., PMID:36974818

B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation., PMID:36927854

Maintenance therapy of low-dose nivolumab, S-1, and leucovorin in metastatic pancreatic adenocarcinoma with a germline mutation of MSH6: A case report., PMID:36582237

[Microsatellite instability in gastric cancer is a predictor of a favorable prognosis]., PMID:36469712

Mismatch repair proteins expression and tumor-infiltrating T-cells in colorectal cancer., PMID:36276483

Validity of a two-antibody testing algorithm for mismatch repair deficiency testing in cancer; a systematic literature review and meta-analysis., PMID:36104536

An Evaluation of the Immunohistochemical Expression of Mismatch Repair Proteins (MSH2, MSH6, MLH1, and PMS2) in Prostate Adenocarcinoma., PMID:36051725

Mismatch Repair Deficiency in Adult Granulosa Cell Tumors: an Immunohistochemistry-based Preliminary Study., PMID:35960021

A Human MSH6 Germline Variant Associated With Systemic Lupus Erythematosus Induces Lupus-like Disease in Mice., PMID:35708944

Immunotherapy in Penile Squamous Cell Carcinoma: Present or Future? Multi-Target Analysis of Programmed Cell Death Ligand 1 Expression and Microsatellite Instability., PMID:35592855

A case of microsatellite instability-high clinically advanced castration-resistant prostate cancer showing a remarkable response to pembrolizumab sustained over at least 18 months., PMID:35487690

The frequency and clinical implication of mismatch repair protein deficiency in Chinese patients with ovarian clear cell carcinoma., PMID:35461222

Datasheet

Document Download

Anti-MSH6 Antibody (R1Y61).pdf

 

$ 290
Product specifications
50 μg 290 100 μg 484

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Anti-MSH6 Antibody (R1Y61) [RHE93102]
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