Catalog No.
RHD54201
Species reactivity
Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
WB: 1:500-1:1000
Target
Orphan nuclear receptor TR3, Nuclear receptor subfamily 4 group A member 1, Nur77, ST-59, HMR, GFRP1, NR4A1, Orphan nuclear receptor HMR, Testicular receptor 3, Nuclear hormone receptor NUR/77, Early response protein NAK1, NAK1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P22736
Applications
WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1S17
Critical roles of chronic BCR signaling in the differentiation of anergic B cells into age-associated B cells in aging and autoimmunity., PMID:40249819
Nuclear receptor 4A1 is critical for neutrophil-dependent pulmonary immunity to Klebsiella pneumoniae infection., PMID:40114913
TIGIT expression in extrahepatic cholangiocarcinoma and its impact on CD8 + T cell exhaustion: implications for immunotherapy., PMID:39939322
Baicalein attenuates ovalbumin-induced allergic rhinitis through the activation of nuclear receptor subfamily 4 group a member 1., PMID:39808359
C-C motif chemokine ligand 5 contributes to radon exposure-induced lung injury by recruiting dendritic cells to activate effector T helper cells., PMID:39746565
A double-edged sword role of IFN-γ-producing iNKT cells in sepsis: Persistent suppression of Treg cell formation in an Nr4a1-dependent manner., PMID:39720538
Predictive and Dynamic Signature for Antiangiogenics in Combination with a PD1 Inhibitor in Soft-Tissue Sarcoma: Correlative Studies Linked to the IMMUNOSARC Trial., PMID:39283727
CSF1R inhibition by PLX5622 reduces pulmonary fungal infection by depleting MHCIIhi interstitial lung macrophages., PMID:39168451
Unveiling the dynamics of B lymphocytes in systemic lupus erythematosus patients treated with belimumab through longitudinal single-cell RNA sequencing., PMID:39037931
Cellular architecture shapes the naïve T cell response., PMID:38843327
Transcriptome Analysis Reveals the Induction of Apoptosis-Related Genes by a Monoclonal Antibody against a New Epitope of CD99 on T-Acute Lymphoblastic Leukemia., PMID:38804310
A Synthetic Circuit Empowering Reprogrammed B Cells for Therapeutic Proteins Expression Regulated by Tumor Detection., PMID:38775140
Modulation of Nuclear Receptor 4A1 Expression Improves Insulin Secretion in a Mouse Model of Chronic Pancreatitis., PMID:38710022
Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy., PMID:39872303
Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice., PMID:36623453
Low-dose anti-VEGFR2 therapy promotes anti-tumor immunity in lung adenocarcinoma by down-regulating the expression of layilin on tumor-infiltrating CD8+T cells., PMID:36260222
CD69-oxLDL ligand engagement induces Programmed Cell Death 1 (PD-1) expression in human CD4 + T lymphocytes., PMID:35930205
Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus., PMID:35177587
Intermediate monocytes induced by IFN-γ inhibit cancer metastasis by promoting NK cell activation through FOXO1 and interleukin-27., PMID:35091454
NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting., PMID:32868928
Activin A overexpression promotes rat follicular development through SCF-kit-mediated cell signals., PMID:32133888
A Bis-Indole-Derived NR4A1 Antagonist Induces PD-L1 Degradation and Enhances Antitumor Immunity., PMID:31911554
Self-reactivity on a spectrum: A sliding scale of peripheral B cell tolerance., PMID:31631352
NR4A Expression by Human Marginal Zone B-Cells., PMID:31614541
Inhibition of NR4A1 Promotes ROS Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma., PMID:31462501
The orphan nuclear receptor NUR77 promotes trophoblast invasion at early pregnancy through paracrine placental growth factor., PMID:31312859
Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery., PMID:30962292
The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases., PMID:30013988
New Drug Candidate Targeting the 4A1 Orphan Nuclear Receptor for Medullary Thyroid Cancer Therapy., PMID:29498706
Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development., PMID:28615655
Identification of two novel isoforms of mouse NUR77 lacking N-terminal domains., PMID:28111880
Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells., PMID:27940659
Transcriptome and Proteome Analyses of TNFAIP8 Knockdown Cancer Cells Reveal New Insights into Molecular Determinants of Cell Survival and Tumor Progression., PMID:27807832
Nur77 gene expression levels were involved in different ACTH-secretion autonomy between Cushing's disease and subclinical Cushing's disease., PMID:27025408
Rasd1, a small G protein with a big role in the hypothalamic response to neuronal activation., PMID:26739966
Tim-3 enhances FcεRI-proximal signaling to modulate mast cell activation., PMID:26598760
Production of Nurr-1 Specific Polyclonal Antibodies Free of Cross-reactivity Against Its Close Homologs, Nor1 and Nur77., PMID:26325389
Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma., PMID:26035713
Nuclear receptors of the NR4a family are not required for the development and function of follicular T helper cells., PMID:25899083
Further characterization of HDAC and SIRT gene expression patterns in pancreatic cancer and their relation to disease outcome., PMID:25275504
Functionally responsive self-reactive B cells of low affinity express reduced levels of surface IgM., PMID:24375379
TR3 modulates platinum resistance in ovarian cancer., PMID:23720056
NR4A1 enhances neural survival following oxygen and glucose deprivation: an in vitro study., PMID:23663895
Gliotoxin is a potent NOTCH2 transactivation inhibitor and efficiently induces apoptosis in chronic lymphocytic leukaemia (CLL) cells., PMID:23278106
Endogenous antigen tunes the responsiveness of naive B cells but not T cells., PMID:22902503
Mantle cell lymphoma displays a homogenous methylation profile: a comparative analysis with chronic lymphocytic leukemia., PMID:22374828
Bone marrow-specific deficiency of nuclear receptor Nur77 enhances atherosclerosis., PMID:22194623
ERK signaling, but not c-Raf, is required for gonadotropin-releasing hormone (GnRH)-induced regulation of Nur77 in pituitary gonadotropes., PMID:22186412
Differential regulation of Nr4a subfamily nuclear receptors following mast cell activation., PMID:21621845
Cellular immediate-early gene expression occurs kinetically upstream of Epstein-Barr virus bzlf1 and brlf1 following cross-linking of the B cell antigen receptor in the Akata Burkitt lymphoma cell line., PMID:20861250
For research use only. Not for human or drug use.
