Catalog No.
YHC33501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe30-Ser390
Predicted molecular weight
42.54 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P08559
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PHE1A, PDHE1-A type I, Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, PDHA1
Modulation of copper homeostasis and cuproptosis by PDHA1 in acute myeloid leukemia., PMID:40493296
Bioinformatics-led identification of pathophysiological hallmark genes in diabesotension via graph clustering method., PMID:40491693
Exploration of PDHA1-related prognostic genes in liver fibrosis., PMID:40489828
Function of eEF-1γ in the nucleus in response to insulin in hepatocellular carcinoma cells., PMID:40442278
Human endogenous retrovirus W family envelope protein (ERVWE1) regulates macroautophagy activation and micromitophagy inhibition via NOXA1 in schizophrenia., PMID:40419114
Multiomics analysis uncovers host-microbiota interactions regulate hybrid vigor traits in geese., PMID:40393267
Short-term methionine deprivation inhibits TCA cycle and regulates macrophage polarization through uncharged tRNA and PDHA1 phosphorylation., PMID:40306332
AARS2-catalyzed lactylation induces follicle development and premature ovarian insufficiency., PMID:40301335
Genetic aetiologies in relation to response to the ketogenic diet in 226 children with epilepsy., PMID:40290421
Novel Synonymous and Deep Intronic Variants Causing Primary and Secondary Pyruvate Dehydrogenase Complex Deficiency., PMID:40225937
Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation., PMID:40180922
Induction of Cuproptosis by Dichloromethane Extract From Patrinia scabiosaefolia Fisch on K562 Cells., PMID:40177825
Genome-wide profiling of a prognostic RNA-binding protein signature in esophageal cancer., PMID:40104740
Pak1 dysregulates pyruvate metabolism in PDAC cells by exerting a phosphorylation-mediated regulatory effect on PDHA1., PMID:40090587
Structural and molecular dysfunctions in granulosa cells: A key contributor to porcine follicular atresia., PMID:40043493
NDUFB7 mutations cause brain neuronal defects, lactic acidosis, and mitochondrial dysfunction in humans and zebrafish., PMID:40025060
Targeting macrophage polarization by inhibiting Pim2 alleviates inflammatory arthritis via metabolic reprogramming., PMID:40000906
Licochalcone A prevents cognitive decline in a lipopolysaccharide-induced neuroinflammation mice model., PMID:39930360
A high-resolution bovine mitochondrial co-expression network., PMID:39898529
Glutaminase-2 Expression Induces Metabolic Changes and Regulates Pyruvate Dehydrogenase Activity in Glioblastoma Cells., PMID:39796278
Case Report: A novel hemizygous missense PDHA1 variant in a Vietnamese boy with pyruvate dehydrogenase E1-alpha deficiency., PMID:39720099
Salmonella-induced SIRT1 and SIRT3 are crucial for maintaining the metabolic switch in bacteria and host for successful pathogenesis., PMID:39693143
Maternal Low-Protein Diet Leads to Mitochondrial Dysfunction and Impaired Energy Metabolism in the Skeletal Muscle of Male Rats., PMID:39684571
Prognostic value and potential biological function of PMSD11 in lung adenocarcinoma., PMID:39678883
GATAD1 is involved in sphingosylphosphorylcholine-attenuated myocardial ischemia-reperfusion injury by modulating myocardial fatty acid oxidation and glucose oxidation., PMID:39626862
Germline genetic variants in a case of familial cancer: RAD51D and four other co-segregated variants., PMID:39445568
Comprehensive analysis of the expression level, prognostic value, and immune infiltration of cuproptosis-related genes in human breast cancer., PMID:39432636
Hippocampal PDHA1 gene knockout inhibits the Warburg effect leading to cognitive dysfunction and attenuates the beneficial effects of ZiBuPiYin recipe on cognition., PMID:39374880
Identification of potential biomarkers of cuproptosis in cerebral ischemia., PMID:39360273
ING5 inhibits aerobic glycolysis of lung cancer cells by promoting TIE1-mediated phosphorylation of pyruvate dehydrogenase kinase 1 at Y163., PMID:39269568
Bioinformatic analysis of hippocampal histopathology in Alzheimer's disease and the therapeutic effects of active components of traditional Chinese medicine., PMID:39221152
Modulation of energetic and lipid pathways by curcumin as a potential chemopreventive strategy in human prostate cancer cells., PMID:39096884
Risk factor prediction and immune correlation analysis of cuproptosis-related gene in osteoarthritis., PMID:39087591
Cuproptosis, the novel type of oxidation-induced cell death in thoracic cancers: can it enhance the success of immunotherapy?, PMID:39068453
Pyruvate dehydrogenase complex E1 subunit α crotonylation modulates cocaine-associated memory through hippocampal neuron activation., PMID:39046876
Reprogramming of Energy Metabolism in Human PKD1 Polycystic Kidney Disease: A Systems Biology Analysis., PMID:39000280
Identification and validation of cuproptosis-related genes in acetaminophen-induced liver injury using bioinformatics analysis and machine learning., PMID:38994365
Astrocyte-secreted lipocalin-2 elicits bioenergetic failure-induced neuronal death that is causally related to high fatality in a mouse model of hepatic encephalopathy., PMID:38964718
Integrated analysis of muscle transcriptome, miRNA, and proteome of Chinese indigenous breed Ningxiang pig in three developmental stages., PMID:38808333
Identification of 10 differentially expressed and cuproptosis-related genes in immune infiltration and prognosis of thyroid carcinoma., PMID:38650151
Variants in mitochondrial disease genes are common causes of inherited peripheral neuropathies., PMID:38549004
PPP3CB Inhibits Cell Proliferation and the Warburg Effect in Bladder Cancer by Blocking PDHK1., PMID:38420800
Glutaminase potentiates the glycolysis in esophageal squamous cell carcinoma by interacting with PDK1., PMID:38353358
Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis., PMID:38347496
The BHLHE40‒PPM1F‒AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer., PMID:38301894
Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation., PMID:38163844
Potential impact of cuproptosis-related genes on tumor immunity in esophageal carcinoma., PMID:38159255
The Complex of p-Tyr42 RhoA and p-p65/RelA in Response to LPS Regulates the Expression of Phosphoglycerate Kinase 1., PMID:38136210
Prioritizing de novo potential non-canonical splicing variants in neurodevelopmental disorders., PMID:38113761
Crosstalk of cuproptosis-related prognostic signature and competing endogenous RNAs regulation in hepatocellular carcinoma., PMID:38078880
For research use only. Not for human or drug use.
