Anti-YES1 Antibody (R1L26)

Catalog No.

RHC28701

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

IP: 1:20, WB: 1:500-1:1000

Target

p61-Yes, Tyrosine-protein kinase Yes, YES1, Proto-oncogene c-Yes, YES

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P07947

Applications

IP, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R1L26

The Moonlighting Function of Glutaminase 2 Promotes Immune Evasion of Pancreatic Ductal Adenocarcinoma by Tubulin Tyrosine Ligase-like 1-Mediated Yes1 Associated Transcriptional Regulator Glutamylation., PMID:39924055

YES1 as a Therapeutic Target for HER2-Positive Breast Cancer after Trastuzumab and Trastuzumab-Emtansine (T-DM1) Resistance Development., PMID:34884609

SRC family kinase (SFK) inhibitor dasatinib improves the antitumor activity of anti-PD-1 in NSCLC models by inhibiting Treg cell conversion and proliferation., PMID:33658304

YES1 amplification confers trastuzumab-emtansine (T-DM1) resistance in HER2-positive cancer., PMID:32572172

Peptide SMIM30 promotes HCC development by inducing SRC/YES1 membrane anchoring and MAPK pathway activation., PMID:32461121

Placental growth factor regulates the pentose phosphate pathway and antioxidant defense systems in human retinal endothelial cells., PMID:32058040

Genome-Wide Analysis Identifies Two Susceptibility Loci for Positive Thyroid Peroxidase and Thyroglobulin Antibodies., PMID:31794020

Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer., PMID:28158234

IGF-1R Inhibition Activates a YES/SFK Bypass Resistance Pathway: Rational Basis for Co-Targeting IGF-1R and Yes/SFK Kinase in Rhabdomyosarcoma., PMID:25925378

The Src kinase Yes is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters, but not pancreatic growth factors, which stimulate its association with numerous other signaling molecules., PMID:22617836

Lyn kinase mediates cell motility and tumor growth in EGFRvIII-expressing head and neck cancer., PMID:22490227

Yes and Lyn play a role in nuclear translocation of the epidermal growth factor receptor., PMID:22430206

A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor., PMID:21037565

Identification of c-Yes expression in the nuclei of hepatocellular carcinoma cells: involvement in the early stages of hepatocarcinogenesis., PMID:17143518

Activation of the lutropin/choriogonadotropin receptor in MA-10 cells leads to the tyrosine phosphorylation of the focal adhesion kinase by a pathway that involves Src family kinases., PMID:16293639

Association of nonreceptor tyrosine kinase c-yes with tight junction protein occludin by coimmunoprecipitation assay., PMID:12616717

Raft.1, a monoclonal antibody raised against the raft microdomain, recognizes G-protein beta1 and 2, which assemble near nucleus after shiga toxin binding to human renal cell line., PMID:12480923

Regulation of the human sperm tyrosine kinase c-yes. Activation by cyclic adenosine 3',5'-monophosphate and inhibition by Ca(2+)., PMID:12080032

Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion., PMID:11698501

beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport., PMID:11546805

Meltrin alpha cytoplasmic domain interacts with SH3 domains of Src and Grb2 and is phosphorylated by v-Src., PMID:11127814

The SRC family protein tyrosine kinase p62yes controls polymeric IgA transcytosis in vivo., PMID:10549294

The influence of interleukin-6 on the growth of human esophageal cancer cell lines., PMID:8974001

fyn tyrosine kinase is involved in keratinocyte differentiation control., PMID:7557381

Requirement for Src family protein tyrosine kinases in G2 for fibroblast cell division., PMID:7545311

The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells., PMID:8356071

A novel Yes-related kinase, Yrk, is expressed at elevated levels in neural and hematopoietic tissues., PMID:8455940

Association between the PDGF receptor and members of the src family of tyrosine kinases., PMID:1696179

Monoclonal antibodies to the amino-terminal sequence of the c-yes gene product as specific probes of its expression., PMID:2183163

Functional expression of the yes proto-oncogene protein in Xenopus oocytes injected with chicken cerebellar mRNA., PMID:2681802

A human nucleolar antigen (pp90) associated with cell growth and its induction by Epstein-Barr virus and human cytomegalovirus., PMID:6094364

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