Anti-FYN Antibody (R1K48)

Catalog No.

RMC19301

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

WB: 1:500-1:1000

Target

FYN, Src-like kinase, Proto-oncogene Syn, Tyrosine-protein kinase Fyn, SLK, Proto-oncogene c-Fyn, p59-Fyn

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P39688

Applications

WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R1K48

Activation of Kir4.1 Channels by 2-D08 Promotes Myelin Repair in Multiple Sclerosis., PMID:40470772

Protectin D1, an omega-3-derived lipid mediator, resolves mast cell-driven allergic inflammation via FcεRⅠ signaling., PMID:40253829

Inhibition of Kinase Activity and In Vitro Downregulation of the Protein Kinases in Lung Cancer and Cervical Cancer Cell Lines and the Identified Known Anticancer Compounds of Ziziphus mucronata., PMID:39942957

Perfluorooctane sulfonate attenuates IgE/Ag-stimulated mast cell activation and anaphylactic responses via activating SHP-1 pathway., PMID:39827624

KIRA6 is an Effective and Versatile Mast Cell Inhibitor of IgE-mediated Activation., PMID:39676406

Antimicrobial Peptide Pro10-1D Exhibits Anti-Allergic Activity: A Promising Therapeutic Candidate., PMID:39596204

Intra- and inter-patient diversity in hepatocellular carcinoma based on phosphorylation profiles-A pilot study in a single institution., PMID:39551467

Long COVID syndrome: An unfolding enigma., PMID:39382470

PTPN22 through the regulation of Th17/Treg balance acts as a potential target for the treatment of Graves' disease., PMID:39083881

The BCR::ABL1 tyrosine kinase inhibitors ponatinib and nilotinib differentially affect endothelial angiogenesis and signalling., PMID:39009935

Aspalathin, a Primary Rooibos Flavonoid, Alleviates Mast Cell-Mediated Allergic Inflammation by the Inhibition of FcεRI Signaling Pathway., PMID:38777857

Development of an Affordable ELISA Targeting the SARS-CoV-2 Nucleocapsid and Its Application to Samples from the Ongoing COVID-19 Epidemic in Ghana., PMID:37462793

3,5,3'-Triiodo-L-Thyronine Regulates Actin Cytoskeleton Dynamic in The Differentiated PC-12 Cells during Hypoxia through An αvβ3 Integrin., PMID:37210645

FYN/TOPK/HSPB1 axis facilitates the proliferation and metastasis of gastric cancer., PMID:37016377

Specific phosphorylation of microtubule-associated protein 2c by extracellular signal-regulated kinase reduces interactions at its Pro-rich regions., PMID:35987383

Salicylaldehyde Suppresses IgE-Mediated Activation of Mast Cells and Ameliorates Anaphylaxis in Mice., PMID:35955959

Network Pharmacological Study on the Mechanism of Cynanchum paniculatum (Xuchangqing) in the Treatment of Bungarus multicinctus Bites., PMID:35837378

A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase-mediated tyrosine phosphorylation., PMID:35820485

Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice., PMID:35492247

Integrative system biology and mathematical modeling of genetic networks identifies shared biomarkers for obesity and diabetes., PMID:35240786

Potential Anti-allergic Effects of Bibenzyl Derivatives from Liverworts, Radula perrottetii., PMID:35081628

Down-regulation of HLA-B-associated transcript 3 impairs the tumoricidal effect of natural killer cells through promoting the T cell immunoglobulin and mucin domain-containing-3 signaling in a mouse head and neck squamous cell carcinoma model., PMID:34968777

Anti-allergic actions of a Chinese patent medicine, huoxiangzhengqi oral liquid, in RBL-2H3 cells and in mice., PMID:34078224

The multi-kinase inhibitor TG02 induces apoptosis and blocks B-cell receptor signaling in chronic lymphocytic leukemia through dual mechanisms of action., PMID:33714981

Plasma membrane lipid scrambling causing phosphatidylserine exposure negatively regulates NK cell activation., PMID:33469162

Mycoplasma hominis septic arthritis in a patient with hypogammaglobinaemia and rheumatoid arthritis., PMID:33468512

Revisiting the phosphotyrosine binding pocket of Fyn SH2 domain led to the identification of novel SH2 superbinders., PMID:33314411

Deep phenotyping of synovial molecular signatures by integrative systems analysis in rheumatoid arthritis., PMID:33230538

Src Family Protein Kinase Controls the Fate of B Cells in Autoimmune Diseases., PMID:33037966

Application of Antibodies to Neuronally Expressed Nogo-A Increases Neuronal Survival and Neurite Outgrowth., PMID:32751444

Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization., PMID:32692785

Tricin Isolated from Enzyme-Treated Zizania latifolia Extract Inhibits IgE-Mediated Allergic Reactions in RBL-2H3 Cells by Targeting the Lyn/Syk Pathway., PMID:32365709

The phosphorylation of CD147 by Fyn plays a critical role for melanoma cells growth and metastasis., PMID:32291412

Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia., PMID:32219444

WZ3146 inhibits mast cell Lyn and Fyn to reduce IgE-mediated allergic responses in vitro and in vivo., PMID:31526816

Sphingomyelin synthase 1 enhances BCR signaling to promote lupus-like autoimmune response., PMID:31262710

Scrodentoid A Inhibits Mast Cell-Mediated Allergic Response by Blocking the Lyn-FcεRIβ Interaction., PMID:31156646

Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration., PMID:31143189

Inhibitory effect of taxifolin on mast cell activation and mast cell-mediated allergic inflammatory response., PMID:30925321

Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers., PMID:30872401

Uroplakins play conserved roles in egg fertilization and acquired additional urothelial functions during mammalian divergence., PMID:30303751

Distinct Gene Expression Patterns between Nasal Mucosal Cells and Blood Collected from Allergic Rhinitis Sufferers., PMID:29920501

Repositioning of anti-cancer drug candidate, AZD7762, to an anti-allergic drug suppressing IgE-mediated mast cells and allergic responses via the inhibition of Lyn and Fyn., PMID:29777684

Evolving Strategies for the Treatment of T-Cell Lymphoma: A Systematic Review and Recent Patents., PMID:29769011

Axonal Guidance Signaling Pathway Is Suppressed in Human Nasal Polyps., PMID:29754498

Pan-SRC kinase inhibition blocks B-cell receptor oncogenic signaling in non-Hodgkin lymphoma., PMID:29567799

Amyloid-β and Tau in Alzheimer's Disease: Novel Pathomechanisms and Non-Pharmacological Treatment Strategies., PMID:29562514

Alcoholic hepatitis versus non-alcoholic steatohepatitis: Levels of expression of some proteins involved in tumorigenesis., PMID:29307797

Simultaneous induction of HSP70 expression, and degranulation, in IgE/Ag-stimulated or extracellular HSP70-stimulated mast cells., PMID:28857181

Suppression of IgE-mediated mast cell activation and mouse anaphylaxis via inhibition of Syk activation by 8-formyl-7-hydroxy-4-methylcoumarin, 4μ8C., PMID:28736076

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