Catalog No.
YHC27301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala114-Thr288
Predicted molecular weight
21.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P07711
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CTSL1, MEP, Procathepsin L, Major excreted protein, Cathepsin L1, CTSL, SARS-like Coronaviruses
Peptidomimetic Phenoxymethyl Ketone Warheads as Potent Dual-Mode Inhibitors against SARS-CoV-2 Mpro and Cathepsin., PMID:40415551
Cathepsin L Aggravates Neuroinflammation via Promoting Microglia M1 Polarization and NLRP3 Activation After Spinal Cord Injury., PMID:40293792
Biochemical analyses of cystatin-C dimers and cathepsin-B reveals a trypsin-driven feedback mechanism in acute pancreatitis., PMID:39962054
Dual Inhibitors of SARS-CoV-2 3CL Protease and Human Cathepsin L Containing Glutamine Isosteres Are Anti-CoV-2 Agents., PMID:39746101
Macrophage-derived cathepsin L promotes epithelial-mesenchymal transition and M2 polarization in gastric cancer., PMID:39713169
Improved recombinant expression of soluble cathepsin B and L in Escherichia coli., PMID:39680170
Study on the causality of cathepsin on autoimmune diseases and cancer: evidence from mendelian randomization analysis., PMID:39673556
The respective roles of TMPRSS2 and cathepsins for SARS-CoV-2 infection in human respiratory organoids., PMID:39601592
Neuronal cathepsin S increases neuroinflammation and causes cognitive decline via CX3CL1-CX3CR1 axis and JAK2-STAT3 pathway in aging and Alzheimer's disease., PMID:39453382
Diphyllin elicits a doubled-pronged attack on the entry of SARS-CoV-2 by inhibiting cathepsin L and furin., PMID:39424146
Cysteine protease I29 propeptide from Calotropis procera R. Br. As a potent cathepsin L inhibitor and its suppressive activity in breast cancer metastasis., PMID:39368988
Peptidomimetic Analogues Act as Effective Inhibitors against SARS-CoV-2 by Blocking the Function of Cathepsin L., PMID:39292661
SARS-CoV-2 Omicron subvariants progressively adapt to human cells with altered host cell entry., PMID:39191389
Hyperglycemia induced cathepsin L maturation linked to diabetic comorbidities and COVID-19 mortality., PMID:39150053
Targeting Caspases 3/6 and Cathepsins L/B May Decrease Laminopathy-Induced Apoptosis in Alzheimer's Disease., PMID:39121120
A dual inhibitor of PIP5K1C and PIKfyve prevents SARS-CoV-2 entry into cells., PMID:39085352
SARS-CoV-2 Spike Protein Induces Time-Dependent CTSL Upregulation in HeLa Cells and Alveolarspheres., PMID:38971996
Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage., PMID:38964470
Cathepsin L induces cellular senescence by upregulating CUX1 and p16INK4a., PMID:38944813
Follicular oocyte as a potential target for severe acute respiratory syndrome coronavirus 2 infection., PMID:38937111
The SPRi determination of cathepsin L and S in plasma and peritoneal fluid of women with endometriosis., PMID:38642611
Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors., PMID:38630165
Establishment, optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting cathepsin L inhibitors., PMID:38518956
Cytoskeletal β-tubulin and cysteine cathepsin L deregulation by SARS-CoV-2 spike protein interaction with the neuronal model cell line SH-SY5Y., PMID:38432290
Cathepsin X deficiency alters the processing and localisation of cathepsin L and impairs cleavage of a nuclear cathepsin L substrate., PMID:38410910
Kidney organoids reveal redundancy in viral entry pathways during ACE2-dependent SARS-CoV-2 infection., PMID:38334329
Klotho Stabilizes the Podocyte Actin Cytoskeleton in Idiopathic Membranous Nephropathy through Regulating the TRPC6/CatL Pathway., PMID:38330925
Cathepsin L inhibition prevents the cleavage of multiple nuclear proteins upon lysis of quiescent human cells., PMID:36606083
Double deficiency of cathepsin B and L in the mouse pancreas alters trypsin activity without affecting acute pancreatitis severity., PMID:36038449
A novel high-risk subpopulation identified by CTSL and ZBTB7B in gastric cancer., PMID:35941174
Reduced Cathepsin L expression and secretion into the extracellular milieu contribute to lung fibrosis in systemic sclerosis., PMID:35900152
COVID-19 receptor and malignant cancers: Association of CTSL expression with susceptibility to SARS-CoV-2., PMID:35414771
Identification of potent small molecule inhibitors of SARS-CoV-2 entry., PMID:35058179
The unfavorable clinical outcome of COVID-19 in smokers is mediated by H3K4me3, H3K9me3 and H3K27me3 histone marks., PMID:35021853
Novel Cysteine Protease Inhibitor Derived from the Haementeria vizottoi Leech: Recombinant Expression, Purification, and Characterization., PMID:34941695
XPA is susceptible to proteolytic cleavage by cathepsin L during lysis of quiescent cells., PMID:34883264
A second functional furin site in the SARS-CoV-2 spike protein., PMID:34856891
Expressions and significances of CTSL, the target of COVID-19 on GBM., PMID:34807310
Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L., PMID:34769210
Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L., PMID:34730959
TFE3 Regulates the Function of the Autophagy-Lysosome Pathway to Drive the Invasion and Metastasis of Papillary Thyroid Carcinoma., PMID:34660181
Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy., PMID:34533563
Discovery of a novel and selective cathepsin L inhibitor with anti-metastatic ability in vitro and in vivo against breast cancer cells., PMID:34426153
Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/L., PMID:34407143
MPI8 is Potent against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L., PMID:34242492
TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells., PMID:34159616
Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion., PMID:33980181
ILRUN Downregulates ACE2 Expression and Blocks Infection of Human Cells by SARS-CoV-2., PMID:33963054
The lnc-CTSLP8 upregulates CTSL1 as a competitive endogenous RNA and promotes ovarian cancer metastasis., PMID:33933142
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development., PMID:33774649
For research use only. Not for human or drug use.
