Catalog No.
YHC25301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg23-Gln161
Predicted molecular weight
17.53 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P07339
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CPSD, CTSD, Cathepsin D
Exploring Exosome Contributions to Gouty Arthritis: A Proteomics and Experimental Study., PMID:40508129
A High Performing Biomarker Signature for Detecting Early-Stage Pancreatic Ductal Adenocarcinoma in High-Risk Individuals., PMID:40507347
Proteins associated with rehospitalization, mortality and diuretic resistance in acutely decompensated heart failure., PMID:40504107
A Biological-Systems-Based Analyses Using Proteomic and Metabolic Network Inference Reveals Mechanistic Insights into Hepatic Lipid Accumulation: An IMI-DIRECT Study., PMID:40502600
Identification of multiomics and immune infiltration-associated biomarkers for early gastric cancer: a machine learning-based diagnostic model development study., PMID:40450287
Proteomics-Based Exploration of the Hepatoprotective Mechanism of α-Lipoic Acid in Rats with Iron Overload-Induced Liver Injury., PMID:40429916
The lysosome-associated SLAMF7 inhibits the development of ovarian cancer by promoting lysosomal damage., PMID:40414453
TFE3-mediated lysosomal biogenesis and homeostasis alleviates arsenic-induced lysosomal and immune dysfunction in macrophages., PMID:40409189
Autophagy Process in Parkinson's Disease Depends on Mutations in the GBA1 and LRRK2 Genes., PMID:40388077
Inhibiting Immune Crosstalk by Modulation of the Intracellular Function and Extracellular Environment of Diseased Microglia to Boost Parkinson's Disease Therapy., PMID:40366277
[Rubioncolin C targets cathepsin D to induce autophagosome accumulation and suppress gastric cancer]., PMID:40350910
Characterization, expression profiling, and immunological role of Cathepsin D in Sebastes schlegelii during bacterial infection., PMID:40339947
Identifying therapeutic target genes for diabetic retinopathy using systematic druggable genome-wide Mendelian randomization., PMID:40301928
Mass spectrometry reveals age-dependent collagen decline in murine atria., PMID:40295212
LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux., PMID:40280227
Mechanism Exploration of Dietary Supplement Astaxanthin on Improving Atherosclerosis through an Integrated Strategy Encompassing Artificial Intelligence Virtual Screening and Experimental Validation., PMID:40265257
Non-coding RNAs (miRNAs - circRNAs - lncRNAs) and genes interact with the regulation of vitiligo., PMID:40186750
Identification of potential crucial genes and biomarkers from neutrophils in sepsis using bioinformatics analysis., PMID:40184094
Cathepsin D inhibits AGEs-induced phenotypic transformation in vascular smooth muscle cells., PMID:40181129
Glycosylation Triggers Cathepsin D Maturation and Secretion to Promote Gastric Cancer Development., PMID:40122458
Multi-Omics Analysis of Hippocampus in Rats Administered Trimethyltin Chloride., PMID:40095120
Integrated Proteomics and Lipidomics Analysis of Hippocampus to Reveal the Metabolic Landscape of Epilepsy., PMID:40092809
Function of lamp2 Gene Response to Vibrio vulnificus Infection and LPS Stimulation in the Half-Smooth Tongue Sole (Cynoglossus semilaevis)., PMID:40076623
Effects of Dietary Copper Sources and Levels on Liver Copper Metabolism and the Expression of Transporters in Growing Pigs., PMID:40003008
Genetic colocalization of cathepsins H, D, and L1 with Alzheimer's disease: Implications for biomarker and therapeutic target discovery., PMID:39982062
From protective enzyme to facilitator of amyloid propagation: Cathepsin D-mediated amyloid fibril fragmentation., PMID:39952498
Analysis and validation of programmed cell death genes associated with spinal cord injury progression based on bioinformatics and machine learning., PMID:39929099
Identification of mitophagy-related biomarkers and immune infiltration in polycystic ovarian syndrome by bioinformatic study., PMID:39916834
Vasoinhibin is Generated by the Renin-angiotensin System., PMID:39903548
Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDAC., PMID:39894886
Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis., PMID:39838395
Construction of the bromodomain-containing protein-associated prognostic model in triple-negative breast cancer., PMID:39827145
Antibodies against the multifaceted cathepsin D protein open new avenues for TNBC immunotherapy., PMID:39800383
Restoring Autophagy by Exercise Ameliorates Insulin Resistance Partly via Calcineurin-Driven TFEB Nuclear Translocation., PMID:39787618
Low-density lipoprotein receptor-related protein 6 ameliorates cardiac hypertrophy by regulating CTSD/HSP90α signaling during pressure overload., PMID:39779966
The Expression of Proteases and the Oligopeptide Transporter PepT1 in the Yolk Sac Membrane, Proventriculus, and Small Intestine During the Development of Anas platyrhynchos domestica Embryo., PMID:39765655
Nonreceptor tyrosine kinase ABL1 regulates lysosomal acidification by phosphorylating the ATP6V1B2 subunit of the vacuolar-type H+-ATPase., PMID:39757940
Targeted demethylation of cathepsin D via epigenome editing rescues pathology in Alzheimer's disease mouse model., PMID:39744681
Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction-associated steatohepatitis., PMID:39726152
N-glycosylation Modification of CTSD Affects Liver Metastases in Colorectal Cancer., PMID:39716927
AMPK protects proximal tubular epithelial cells from lysosomal dysfunction and dedifferentiation induced by lipotoxicity., PMID:39675352
Restoration of lysosomal function attenuates autophagic flux impairment in nucleus pulposus cells and protects against mechanical overloading-induced intervertebral disc degeneration., PMID:39675125
GsMTx4 Combined with Exercise Exerts Neuroprotective Effects by Regulating Neuronal Autophagy in Rats with Spinal Cord Injury., PMID:39666140
A Novel Variant of the CTSD Gene Associated with Juvenile-onset Neuronal Ceroid Lipofuscinosis Type 10: A Case Report and Literature Review., PMID:39656415
[Plasma long noncoding RNA expression profiles in patients with Parkinson's disease and the role of lnc-CTSD-5:1 in a PD cell model: a ceRNA microarray-based study]., PMID:39623270
Apoptosis, MAPK signaling pathway affected in tilapia liver following nano-microplastics and sulfamethoxazole acute co-exposure., PMID:39616671
Studies on the Role of MAP4K2, SPI1, and CTSD in Osteoporosis., PMID:39586961
Vitamin D promotes autophagy to inhibit LPS-induced lung injury via targeting cathepsin D., PMID:39570382
New preclinical biomarkers for prion diseases in the cerebrospinal fluid proteome revealed by mass spectrometry., PMID:39520708
For research use only. Not for human or drug use.
