Catalog No.
RHB63701
Species reactivity
Human, Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IP: 1:20, WB: 1:500-1:1000
Target
RAPGEF3, cAMP-GEFI, cAMP-regulated guanine nucleotide exchange factor I, EPAC1, EPAC 1, Exchange protein directly activated by cAMP 1, Rap guanine nucleotide exchange factor 3, Exchange factor directly activated by cAMP 1, Rap1 guanine-nucleotide-exchange factor directly activated by cAMP, EPAC, CGEF1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O95398
Applications
IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1G48
Unraveling the role of Epac1-SOCS3 signaling in the development of neonatal-CRD-induced visceral hypersensitivity in rats., PMID:35702948
Identification and Characterization of an Affimer Affinity Reagent for the Detection of the cAMP Sensor, EPAC1., PMID:34571955
Membrane-permeable Rab27A is a regulator of the acrosome reaction: Role of geranylgeranylation and guanine nucleotides., PMID:29337043
Cardiac fibroblast transcriptome analyses support a role for interferogenic, profibrotic, and inflammatory genes in anti-SSA/Ro-associated congenital heart block., PMID:28626076
Epac activation sensitizes rat sensory neurons through activation of Ras., PMID:26596174
Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes., PMID:25829540
Nerve growth factor mediates a switch in intracellular signaling for PGE2-induced sensitization of sensory neurons from protein kinase A to Epac., PMID:25126967
Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion., PMID:23867755
Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a β2-adrenergic receptor/adenylyl cyclase/Epac-1/inositol 1,4,5-trisphosphate pathway in endothelial cells., PMID:22167199
Renal expression of exchange protein directly activated by cAMP (Epac) 1 and 2., PMID:18495799
cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics., PMID:18346875
Calcium-induced acrosomal exocytosis requires cAMP acting through a protein kinase A-independent, Epac-mediated pathway., PMID:16407249
Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin-epithelin precursor (GEP), a prosurvival factor for ovarian cancer., PMID:16044162
Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU., PMID:15613546
MAP1A light chain 2 interacts with exchange protein activated by cyclic AMP 1 (EPAC1) to enhance Rap1 GTPase activity and cell adhesion., PMID:15591041
For research use only. Not for human or drug use.
