Catalog No.
YHC23201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu334
Predicted molecular weight
38.95 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P07195
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LDHB, LDH-B, L-lactate dehydrogenase B chain, LDH heart subunit, LDH-H, Renal carcinoma antigen NY-REN-46
Contrasting Becker and Duchenne muscular dystrophy serum biomarker candidates by using data independent acquisition LC-MS/MS., PMID:40483507
Resveratrol mitigates cold exposure-induced apoptosis and energy metabolism disorder in broiler heart by mediating the p38-PI3K/AKT-NF-κB axis., PMID:40460596
The effect of lactate dehydrogenase B and its mediated histone lactylation on chondrocyte ferroptosis during osteoarthritis., PMID:40394653
Stallion spermatozoa express LDH isoforms A, B, and C, with LDHC playing a crucial role in sustaining sperm viability., PMID:40299647
Exercise-Mediated Mechanical Stress Promotes Osteogenic Differentiation of BMSCs Through Upregulation of Lactylation via the IER3/LDHB Axis., PMID:40244862
LDHB suppresses the PDCoV proliferation by targeting viral nucleocapsid protein for autophagic degradation., PMID:40231829
LDHB silencing enhances the effects of radiotherapy by impairing nucleotide metabolism and promoting persistent DNA damage., PMID:40158058
RNA-binding protein expression based machine learning model predicts metastasis and treatment outcome of testicular cancer., PMID:40138122
Ubiquinol-mediated suppression of mitochondria-associated ferroptosis is a targetable function of lactate dehydrogenase B in cancer., PMID:40090955
Ectopic protein lysine methacrylation contributes to defects caused by loss of HIBCH or ECHS1., PMID:40056416
Histone Lactylation-Driven Ubiquitin-Specific Protease 34 Promotes Cisplatin Resistance in Hepatocellular Carcinoma., PMID:40051889
Lactate dehydrogenase B deficiency-dependent hyperlactatemia coordinates with necroptosis to worsen septic liver and kidney injuries., PMID:40043615
Ethoxychelerythrine as a potential therapeutic strategy targets PI3K/AKT/mTOR induced mitochondrial apoptosis in the treatment of colorectal cancer., PMID:39994297
Metabolic deficiencies underlie reduced plasmacytoid dendritic cell IFN-I production following viral infection., PMID:39920132
Lactate Promotes Hypoxic Granulosa Cells' Autophagy by Activating the HIF-1α/BNIP3/Beclin-1 Signaling Axis., PMID:39858561
Discovery of a potent PROTAC degrader for RNA demethylase FTO as antileukemic therapy., PMID:39807332
Lactylation modulation identifies key biomarkers and therapeutic targets in KMT2A-rearranged AML., PMID:39789150
HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis., PMID:39731912
The expression of glycolysis-related proteins in urine significantly increases after running., PMID:39717827
Metabolism-related proteins as biomarkers for predicting prognosis in polycystic ovary syndrome., PMID:39702179
Microenvironmental G protein-coupled estrogen receptor-mediated glutamine metabolic coupling between cancer-associated fibroblasts and triple-negative breast cancer cells governs tumour progression., PMID:39690134
Hydrogen sulfide attenuates disturbed flow-induced vascular remodeling by inhibiting LDHB-mediated autophagic flux., PMID:39647238
Lactate dehydrogenase B noncanonically promotes ferroptosis defense in KRAS-driven lung cancer., PMID:39643712
Synthesis of 1-Hydroxy(and 1-Alkoxy, 1-Acyloxy)-1H-indoles and evaluations of their suppressive activities against tumor growth through inhibiting lactate dehydrogenase A., PMID:39642694
Dipeptide alanine-glutamine ameliorates retinal neurodegeneration in an STZ-induced rat model., PMID:39629074
Mechanism of jianxin granules in the treatment of heart failure based on proteomics and metabolomics., PMID:39605071
LDHB Mediates Histone Lactylation to Activate PD-L1 and Promote Ovarian Cancer Immune Escape., PMID:39587817
Diminished lactate utilization in LDHB-deficient neurons leads to impaired long-term memory retention., PMID:39566837
Transcriptomic analysis of melatonin on the mechanism of embryonic gonadal development in female Jilin white geese., PMID:39566171
The splicing factor SF3B1 is essential for proper alternative splicing and zygotic genome activation in early porcine embryos., PMID:39521214
Identification of Genetic Associations of IDH2, LDHA, and LDHB Genes with Milk Yield and Compositions in Dairy Cows., PMID:39459528
RABIF promotes hepatocellular carcinoma progression through regulation of mitophagy and glycolysis., PMID:39414994
Identification of key differentially methylated genes regulating muscle development in chickens: insights from Jingyuan breed., PMID:39316980
Lactylation signature identifies liver fibrosis phenotypes and traces fibrotic progression to hepatocellular carcinoma., PMID:39257588
Lactate dehydrogenase-1 may play a key role in the brain energy disturbance caused by cryptococcal meningitis., PMID:39214781
Effects of Pulsed Electromagnetic Field Treatment on Skeletal Muscle Tissue Recovery in a Rat Model of Collagenase-Induced Tendinopathy: Results from a Proteome Analysis., PMID:39201538
SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB., PMID:39147351
Reprogramming of Energy Metabolism in Human PKD1 Polycystic Kidney Disease: A Systems Biology Analysis., PMID:39000280
Integrative multi-omics analysis unravels the host response landscape and reveals a serum protein panel for early prognosis prediction for ARDS., PMID:38956604
Creatine kinase mitochondrial 2 promotes the growth and progression of colorectal cancer via enhancing Warburg effect through lactate dehydrogenase B., PMID:38952967
Immunohistochemical localization of HCA1 receptor in placenta in presence of fetal growth restriction., PMID:38909565
Characterization of an African swine fever virus outbreak in India and comparative analysis of immune genes in infected and surviving crossbreed vs. indigenous Doom pigs., PMID:38864875
The walnut-derived peptide TW-7 improves mouse parthenogenetic embryo development of vitrified MII oocytes potentially by promoting histone lactylation., PMID:38858724
PGC-1α loss promotes mitochondrial protein lactylation in acetaminophen-induced liver injury via the LDHB-lactate axis., PMID:38810904
Transcriptome analysis of adipose tissue and muscle of Laiwu and Duroc pigs., PMID:38766520
Fibroblast growth factor pathway promotes glycolysis by activating LDHA and suppressing LDHB in a STAT1-dependent manner in prostate cancer., PMID:38764020
Network pharmacology and molecular docking technology for exploring the effect and mechanism of high-dose vitamin c on ferroptosis of tumor cells: A review., PMID:38758839
Lactate regulates respiratory efficiency and mitochondrial dynamics in primary rat podocytes., PMID:38740101
Epigenetic silencing of LDHB promotes hepatocellular carcinoma by remodeling the tumor microenvironment., PMID:38739169
Lactate dehydrogenase B as a metabolism-related marker for immunotherapy in head and neck squamous cell carcinoma., PMID:38719019
For research use only. Not for human or drug use.
