Catalog No.
YHH62402
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln375-Glu589
Predicted molecular weight
27.71 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q3KR37
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GRAM domain-containing protein 1B, Protein Aster-B, GRAMD1B, KIAA1201
METTL3 promotes the hypertrophic scar fibrosis via m6A RNA methylation of GRAMD1B mRNA., PMID:40515792
GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau., PMID:40204713
Distinct pathways for the absorption and metabolism of β-carotene and zeaxanthin in the mouse intestine., PMID:39971162
Using GRAM Domain-Based Biosensors to Monitor Accessible Cholesterol Distribution in Live Cells., PMID:39699725
Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence., PMID:38499654
MiR-4646-5p Acts as a Tumor-Suppressive Factor in Triple Negative Breast Cancer and Targets the Cholesterol Transport Protein GRAMD1B., PMID:38250802
Construction of a 5-gene prognostic signature based on oxidative stress related genes for predicting prognosis in osteosarcoma., PMID:38039294
Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake., PMID:37943936
Visualization of accessible cholesterol using a GRAM domain-based biosensor., PMID:37880244
Genetic overlap between Alzheimer's disease and immune-mediated diseases: An atlas of shared genetic determinants and biological convergence., PMID:37841839
Regulation of cellular cholesterol distribution via non-vesicular lipid transport at ER-Golgi contact sites., PMID:37735529
Molecular characterization of extracellular vesicles derived from follicular fluid of women with and without PCOS: integrating analysis of differential miRNAs and proteins reveals vital molecules involving in PCOS., PMID:36695944
Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma., PMID:36259947
Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking., PMID:36122218
Construction and evaluation of a prognostic risk model of tumor metastasis-related genes in patients with non-small cell lung cancer., PMID:36056349
Aster proteins mediate carotenoid transport in mammalian cells., PMID:35394870
Effects of Aster B-mediated intracellular accumulation of cholesterol on inflammatory process and myocardial cells in acute myocardial infarction., PMID:34147675
GRAMD1-mediated accessible cholesterol sensing and transport., PMID:33932585
Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b., PMID:33604931
Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms., PMID:33376205
STARD1 Functions in Mitochondrial Cholesterol Metabolism and Nascent HDL Formation. Gene Expression and Molecular mRNA Imaging Show Novel Splicing and a 1:1 Mitochondrial Association., PMID:33193082
Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport., PMID:32738348
Fast Algorithms for Conducting Large-Scale GWAS of Age-at-Onset Traits Using Cox Mixed-Effects Models., PMID:32132097
Circular RNA circGRAMD1B inhibits gastric cancer progression by sponging miR-130a-3p and regulating PTEN and p21 expression., PMID:31719211
NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress., PMID:31537798
GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling., PMID:29934528
GRAM domain-containing protein 1B (GRAMD1B), a novel component of the JAK/STAT signaling pathway, functions in gastric carcinogenesis., PMID:29383166
Genome-wide association study for female fertility in Nordic Red cattle., PMID:26369327
2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity., PMID:24619206
Genome-wide association study for levels of total serum IgE identifies HLA-C in a Japanese population., PMID:24324648
A transcriptome-wide screen for mRNAs enriched in fetal Leydig cells: CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesis., PMID:23133512
For research use only. Not for human or drug use.
