Catalog No.
RHD84101
Species reactivity
Human, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:100-1:200, WB: 1:1000-1:2000
Target
CASP-1, ICE, IL-1 beta converting enzyme, IL-1BC, IL1BCE, caspase-1, Caspase 1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P29466
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4 ℃ short term (1-2 weeks).
Store at -20 ℃ 12 months.
Store at -80 ℃ long term.
Clone ID
R1B68
HERV-W Env Induces Neuron Pyroptosis via the NLRP3-CASP1-GSDMD Pathway in Recent-Onset Schizophrenia., PMID:39859234
Regulatory T cell expansion prevents retinal degeneration in type 2 diabetes., PMID:39716335
Particulate Matter Induces NLRP3 Inflammasome-Mediated Pyroptosis in Human Nasal Epithelial Cells., PMID:39664405
Allergy and autoinflammation drive persistent systemic inflammatory response in Meniere Disease: A longitudinal study., PMID:39622350
Effect and Mechanism of Mycobacterium avium MAV-5183 on Apoptosis of Mouse Ana-1 Macrophages., PMID:38430410
Nasal administration of anti-CD3 mAb (Foralumab) downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells in subjects with COVID-19., PMID:36881624
Neurobiochemical, Peptidomic, and Bioinformatic Approaches to Characterize Tauopathy Peptidome Biomarker Candidates in Experimental Mouse Model of Traumatic Brain Injury., PMID:36635478
Biglycan as a mediator of proinflammatory response and target for MDS and sAML therapy., PMID:36531688
Lung Inflammasome Activation in SARS-CoV-2 Post-Mortem Biopsies., PMID:36361818
Exploring the relationship between pyroptosis, infiltrating immune cells and Kawasaki disease with resistance to intravenous immunoglobulin (IVIG) via bioinformatic analysis., PMID:36029669
Intestinal Epithelial Responses to IL-17 in Adult Stem Cell-derived Human Intestinal Organoids., PMID:35927216
Tfh cells with NLRP3 inflammasome activation are essential for high-affinity antibody generation, germinal centre formation and autoimmunity., PMID:35414518
Citrullinated Histone H3 Mediates Sepsis-Induced Lung Injury Through Activating Caspase-1 Dependent Inflammasome Pathway., PMID:34950139
Artificial Neural Networks Predicted the Overall Survival and Molecular Subtypes of Diffuse Large B-Cell Lymphoma Using a Pancancer Immune-Oncology Panel., PMID:34945004
Suppression of the caspase-1/GSDMD-mediated pyroptotic signaling pathway through dexamethasone alleviates corneal alkali injuries., PMID:34822855
LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization., PMID:34802379
Cytotoxin-associated gene A (CagA) promotes aortic endothelial inflammation and accelerates atherosclerosis through the NLRP3/caspase-1/IL-1β axis., PMID:34670018
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway., PMID:34614429
VaximmutorDB: A Web-Based Vaccine Immune Factor Database and Its Application for Understanding Vaccine-Induced Immune Mechanisms., PMID:33777032
Cryptococcus neoformans Secretes Small Molecules That Inhibit IL-1β Inflammasome-Dependent Secretion., PMID:33380899
Long noncoding RNA MIAT regulates primary human retinal pericyte pyroptosis by modulating miR-342-3p targeting of CASP1 in diabetic retinopathy., PMID:33065089
Peripheral blood expression levels of inflammasome complex components in two different focal epilepsy syndromes., PMID:32731050
Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity., PMID:32332737
No Major Effect of Innate Immune Genetics on Acute Kidney Rejection in the First 2 Weeks Post-Transplantation., PMID:32153387
Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation., PMID:32019420
Lipoxin A4 suppresses angiotensin II type 1 receptor autoantibody in preeclampsia via modulating caspase-1., PMID:32001671
Signature of genome wide gene expression in classical swine fever virus infected macrophages and PBMCs of indigenous vis-a-vis crossbred pigs., PMID:31935504
Inflammasome Activation in Human Macrophages Induced by a LDL (-) Mimetic Peptide., PMID:31858317
FliC's Hypervariable D3 Domain Is Required for Robust Anti-Flagellin Primary Antibody Responses., PMID:31488506
Activation of P2X7R- NLRP3 pathway in Retinal microglia contribute to Retinal Ganglion Cells death in chronic ocular hypertension (COH)., PMID:31445901
MiR-187-3p mimic alleviates ischemia-reperfusion-induced pain hypersensitivity through inhibiting spinal P2X7R and subsequent mature IL-1β release in mice., PMID:31100367
Emerging views of mitophagy in immunity and autoimmune diseases., PMID:30951392
Pannexin 1 Channels Contribute to IL-1β Expression via NLRP3/Caspase-1 Inflammasome in Aspergillus Fumigatus Keratitis., PMID:30793631
Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV., PMID:30634407
Inflammatory Mediator Expression Associated With Antibody Response Induced by Live Attenuated vs Inactivated Influenza Virus Vaccine in Children., PMID:30515427
Effect of massage therapy by VOSKIN 125+ painkiller® on inflammatory skin lesions., PMID:30133870
Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation., PMID:30019185
mTORC2 Activity Disrupts Lysosome Acidification in Systemic Lupus Erythematosus by Impairing Caspase-1 Cleavage of Rab39a., PMID:29866702
P2X7 receptor mediates NLRP3-dependent IL-1β secretion and parasite proliferation in Toxoplasma gondii-infected human small intestinal epithelial cells., PMID:29291748
Interleukin 6 receptor inhibitor tocilizumab suppresses cytokine expression, inflammasome activation and phagocytosis in a cell model of sepsis., PMID:29441967
Upregulation of NLRP3 inflammasome components in Mooren's ulcer., PMID:27796668
Comparative ontogenetic development of two marine teleosts, gilthead seabream and European sea bass: New insights into nutrition and immunity., PMID:27317010
Fish-oil-derived n-3 polyunsaturated fatty acids reduce NLRP3 inflammasome activity and obesity-related inflammatory cross-talk between adipocytes and CD11b(+) macrophages., PMID:27208584
Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants., PMID:26555265
Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection., PMID:26032420
Blockade of vascular endothelial growth factor receptor 1 prevents inflammation and vascular leakage in diabetic retinopathy., PMID:25821590
Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation., PMID:25744023
Inflammation and pyroptosis mediate muscle expansion in an interleukin-1β (IL-1β)-dependent manner., PMID:25596528
Gilthead seabream (Sparus aurata) immune responses are modulated after feeding with purified antinutrients., PMID:24924098
Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-κB signaling., PMID:24706726
For research use only. Not for human or drug use.
